S. D. Deosarkar

Partial molar volumes of isoniazid solutions in aqueous-ethanol mixtures at 298.15 K

Densities (ρ) of antitubercular drug isoniazid solutions in water, aqueous-ethanol (20–80 vol % EtOH) and in pure ethanol at 298.15 K with different molar concentrations (0.01–0.16 mol dm−3) were measured. Experimental density data were used to calculate apparent molar volumes (φv) of isoniazid in different media. The φv data were fitted to Massons relation and partial molar volumes (φv0) of drug for infinitely dilute solution were determined for each solution. Experimental and derived properties were interpreted in terms of drug-solvent molecular interactions and structural fittings in studied systems.

Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15 K

Article history: Received on: 27/03/2015 Revised on: 12/04/2015 Accepted on: 03/05/2015 Available online: 27/05/2015 In view of pharmaceutical applications, the density (ρ) and refractive index (nD) of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug. Apparent molar volumes (φv) were calculated from density data and fitted to the Masson relation to determine partial molar volume (φ °v) of drug. Overall, strong drugsolvent interactions with significant structural changes in pure and mixed solvents have been confirmed.

Molar Refraction and Polarizability of Antiemetic drug 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate in {Aqueous-Sodium or Lithium Chloride} Solutions at 30oC.

The 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate exhibits antiemetic and parasympathomimetic activity. Density (ρ) and refractive index (nD) measurements were carried out as a function of drug concentration (c=0.01-0.11 mol•L-1 ) in aqueous NaCl/LiCl (c=0.05, 0.10 and 0.15 mol•L-1 ) solutions at 30 °C. Linear relation of concentration dependence of density and refractive index were studied. Molar refractivity (RM) of solution was calculated from density and refractive index data and polarizability (α) was calculated from molar refractivity data. Stronger polarizability effects have been observed K with increase in drug concentration.

Concentration dependences of density, viscosity, refractive index, and other derived properties of metoclopramide aqueous solutions at 303.15 K

Density (ρ), viscosity (η) and refractive index (nD) of an antiemetic drug metoclopramide (4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride) solutions containing amino acids (glycine, D-alanine, L-cystine and L-histidine) were measured in the concentration range 0.01–0.17 mol/dm3 at 303.15 K. The apparent molar volume (φv) of this drug in aqueous amino acid solutions was calculated from the density data and fitted to the Massons relation, and the partial molar volume φv0 of the drug was determined graphically. The partial molar volumes of transfer (Δtrφv0) of drug at infinite dilution from pure water to aqueous amino acid solutions were calculated and interpreted in terms of different interactions between the drug and amino acids.

Volumetric and optical properties of ACE inhibitor captopril in aqueous-alcoholic mixtures

Abstract Captopril is an angiotensin-converting enzyme (ACE) inhibitor that is used for the treatment of hypertension and congestive heart failure. This article addresses the accurate measurements of densities and refractive indices of solutions containing captopril in pure solvents such as water, methanol, ethanol and 1-propanol and aqueous mixtures of methanol, ethanol and propan-1-ol of 30%, 50% and 70% by volume in a wide range of drug concentration at 26 °C. This article also includes the evaluation of apparent molar volume, partial molar volume at infinite dilution and transfer volumes. The concentration dependence of the refractive indices studied and respective fitting parameters have been reported. Different properties are interpreted in terms of intermolecular interactions, effect of drug on structure of solvent/solvent mixture and overall structural fittings in solutions.

Refractivity and polarizability of mixtures of L-histidine–metformin hydrochloride–water at 30°C

The molar refractivity and polarizability of mixtures of L-histidine (0.01–0.11 mol L–1)–metformin hydrochloride (0.03, 0.05, 0.07 mol L–1)–water were calculated from density and refractive index data at 30°C. Enhancement in the polarizability has been observed with increase in L-histidine concentration as well as metformin hydrochloride content in the solution. The molar refractivity and polarizability of solutions increased appreciably after 0.09 mol L–1 L-histidine in each aqueous solution.

Solution behavior of metoclopramide in aqueous-alcoholic solutions at 30°C

Densities (ρ) and refractive indices (nD) of solutions of antiemetic drug metoclopramide (4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride hydrate) in methanolwater and ethanol-water mixtures of different compositions were measured at 30°C. Apparent molar volume (φv) of the drug was calculated from density data and partial molar volumes (φv0) were determined from Massons relation. Concentration dependence of nD has been studied to determine refractive indices of solution at infinite dilution (nD0). Results have been interpreted in terms of solute-solvent interactions.

Effect of electron withdrawing groups on near infrared absorption of quinaldine-based squaraine dyes

The quinaldinium salt possessing electron withdrawing (-COOEt) groups was condensed with squaric acid giving the quinaldine based symmetrical squaraine dye. Effect of electron withdrawing group on near infrared absorption of the squaraine dye has been studied. Results showed that electron withdrawing group shifts bathochromically the absorption wavelength of squaraine dye by 31 nm when compared with the unsubstituted dye. Computational studies were performed in order to understand the charge transfer and red shift and later have been attributed to the increased biradicaloid character.

Partial molar volumes and viscous properties of glycine-aqueous urea solutions at 298.15 K

Density (ρ) and viscosity (η) of glycine (c = 0.02–0.22 mol dm−3) in aqueous urea (c = 0.5, 1.5, and 3.0 mol dm−3) solutions were measured at 298.15 K. Experimental density data has been used to calculate apparent molar volumes (φv) of glycine in aqueous and aqueous-urea solutions at 298.15 K. The dependence of apparent molar volumes on concentration of glycine was fitted to the Massons relation and apparent molar volume of glycine at infinite dilution (partial molar volume, φv0) was determined graphically. The partial molar volumes of transfer (Δtrφv0) of glycine at infinite dilution from pure water to aqueous-urea solutions at 298.15 K were calculated and interpreted in terms of various interactions and structural fittings in studied solutions. The relative viscosity data has been analyzed by Jones-Dole relation and viscosity B-coefficients were determined graphically. Viscosity B-coefficient of transfer (ΔB) was also calculated and compared with Δtrφv0.

Partial molar volumes and viscosities of aqueous hippuric acid solutions containing LiCl and MnCl2 · 4H2O at 303.15 K

Density (ρ) and viscosity (η) of aqueous hippuric acid (HA) solutions containing LiCl and MnCl2 · 4H2O have been studied at 303.15 K in order to understand volumetric and viscometric behavior of these systems. Apparent molar volume (φv) of salts were calculated from density data and fitted to Massons relation and partial molar volumes (φv0) at infinite dilution were determined. Relative viscosity data has been used to determine viscosity A and B coefficients using Jones-Dole relation. Partial molar volume and viscosity coefficients have been discussed in terms of ion-solvent interactions and overall structural fittings in solution.