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S. David Brown

Exelixis

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Publication

Featured researches published by S. David Brown.

Bioorganic & Medicinal Chemistry Letters | 2002

Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1.

Adrian Folkes; S. David Brown; Lynne Canne; Jocelyn Chan; Erin Engelhardt; Sergey Epshteyn; Richard Faint; Julian Golec; Art Hanel; Patrick Kearney; James W. Leahy; Morrison B. Mac; David A. Matthews; Michael P. Prisbylla; Jason Terry Sanderson; Reyna J. Simon; Zerom Tesfai; Nigel Vicker; Shouming Wang; Robert R. Webb; Peter Charlton

We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.

Archive | 2006

N- (3-amino-quinoxalin-2-yl) -sulfonamide derivatives and their use as phosphatidylinositol 3-kinase inhibitors

William Bajjalieh; Lynne Canne Bannen; S. David Brown; Patrick Kearney; Morrison B. Mac; Charles K. Marlowe; John M. Nuss; Zerom Tesfai; Yong Wang; Wei Xu

Archive | 2007

4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use

Grace Mann; Naing Aay; Arlyn Arcalas; S. David Brown; Wai Ki Vicky Chan; Jeff Chen; Hongwang Du; Sergey Epshteyn; Timothy Patrick Forsyth; Adam Antoni Galan; Tai Phat Huynh; Mohamed Abdulkader Ibrahim; Henry William Beecroft Johnson; Brian Kane; Patrick Kearney; Byung Gyu Kim; Elena S. Koltun; James W. Leahy; Matthew Sangyup Lee; Gary L. Lewis; Lisa E. Meyr; Robin Tammie Noguchi; Michael Pack; Brian Hugh Ridgway; Xian Shi; John Woolfrey; Peiwen Zhou

Archive | 2011

Phosphatidylinositol 3-kinase inhibitors and methods of their use

William Bajjalieh; Lynne Canne Bannen; S. David Brown; Patrick Kearney; Morrison B. Mac; Charles K. Marlowe; John M. Nuss; Zerom Tesfai; Yong Wang; Wei Xu

Archive | 2006

Aminopyrimidine, aminopyridine and aniline derivatives inhibitors of pim-i and/or pim-3

Patrick Kearney; S. David Brown; Elena S. Koltun

Archive | 2008

Benzofuropyrimidinones as protein kinase inhibitors

S. David Brown; Hongwang Du; Maurizio Franzini; Adam Antoni Galan; Ping Huang; Patrick Kearney; Moon Hwan Kim; Elena S. Koltun; Steven James Richards; Amy Lew Tsuhako; Cristiana A. Zaharia

Archive | 2008

6-PHENYLPYRIMIDINONES AS PIM MODULATORS

Amy Lew Tsuhako; Naing Aay; S. David Brown; Wai Ki Vicky Chan; Hongwang Du; Ping Huang; Brian Kane; Patrick Kearney; Moon Hwan Kim; Elena S. Koltun; Michael Pack; Wei Xu; Peiwen Zhou

Archive | 2007

4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and pharmaceutical compositions containing them

Grace Mann; Naing Aay; Arlyn Arcalas; S. David Brown; Wai Ki Vicky Chan; Jeff Chen; Hongwang Du; Sergey Epshteyn; Timothy Patrick Forsyth; Adam Antoni Galan; Tai Phat Huynh; Mohamed Abdulkader Ibrahim; Henry William Beecroft Johnson; Brian Kane; Patrick Kearney; Byung Gyu Kim; Elena S. Koltun; James W. Leahy; Matthew Sangyup Lee; Gary L. Lewis; Lisa E. Meyr; Robin Tammie Noguchi; Michael Pack; Brian Hugh Ridgway; Xian Shi; John R. Woolfrey; Peiwen Zhou

Archive | 2012

(alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases

S. David Brown; David J. Matthews

Blood | 2012

Preclinical Characterization of PWT143, a Novel Selective and Potent Phosphatidylinositol 3-kinase Delta (PI3K delta) Inhibitor with Ex-Vivo Activity in Hematologic Malignancies.

Marie O'Farrell; Richard Ventura; Albert K. Tai; Jeffrey W. Tyner; Marc Loriaux; Daruka Mahadevan; Carla Morales; S. David Brown; David J. Matthews

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Patrick Kearney

Exelixis

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Morrison B. Mac

Exelixis

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Elena S. Koltun

Genzyme

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John M. Nuss

Exelixis

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Moon Hwan Kim

Exelixis

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Hongwang Du

Genzyme

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Wei Xu

Exelixis

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Zerom Tesfai

Exelixis

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David J. Matthews

Exelixis

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Adam Antoni Galan

Exelixis

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