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Dive into the research topics where Zerom Tesfai is active.

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Featured researches published by Zerom Tesfai.


Bioorganic & Medicinal Chemistry Letters | 2002

Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1.

Adrian Folkes; S. David Brown; Lynne Canne; Jocelyn Chan; Erin Engelhardt; Sergey Epshteyn; Richard Faint; Julian Golec; Art Hanel; Patrick Kearney; James W. Leahy; Morrison B. Mac; David A. Matthews; Michael P. Prisbylla; Jason Terry Sanderson; Reyna J. Simon; Zerom Tesfai; Nigel Vicker; Shouming Wang; Robert R. Webb; Peter Charlton

We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.


Archive | 2003

Protein kinase modulators and methods of use

Chris A. Buhr; Tae-Gon Baik; Sunghoon Ma; Zerom Tesfai; Longcheng Wang; Erick Wang Co; Sergey Epshteyn; Abigail R. Kennedy; Baili Chen; Larisa Dubenko; Neel Kumar Anand; Tsze H. Tsang; John M. Nuss; Csaba J. Peto; Kenneth D. Rice; Mohamed Abdulkader Ibrahim; Kevin Luke Schnepp; Xian Shi; James W. Leahy; Jeff Chen; Lisa Esther Dalrymple; Thimothy Patrick Forsyth; Tai Phat Huynh; Grace Mann; Lary Wayne Mann; Craig Stacy Takeuchi


Archive | 2006

N- (3-amino-quinoxalin-2-yl) -sulfonamide derivatives and their use as phosphatidylinositol 3-kinase inhibitors

William Bajjalieh; Lynne Canne Bannen; S. David Brown; Patrick Kearney; Morrison B. Mac; Charles K. Marlowe; John M. Nuss; Zerom Tesfai; Yong Wang; Wei Xu


Archive | 2008

inhibitors of the hedgehog pathway

Suleyman Bahceci; William Bajjalieh; Jeff Chen; Sergey Epshteyn; Timothy Patrick Forsyth; Tai Phat Huynh; Byung Gyu Kim; James W. Leahy; Matthew Sangyup Lee; Gary L. Lewis; Morrison B. Mac; Grace Mann; Charles K. Marlowe; Brian Hugh Ridgway; Joan C. Sangalang; Xian Shi; Craig Stacy Takeuchi; Yong Wang; Zerom Tesfai


Archive | 2011

Phosphatidylinositol 3-kinase inhibitors and methods of their use

William Bajjalieh; Lynne Canne Bannen; S. David Brown; Patrick Kearney; Morrison B. Mac; Charles K. Marlowe; John M. Nuss; Zerom Tesfai; Yong Wang; Wei Xu


Archive | 2005

Pyrazole kinase modulators and methods of use

Tae-Gon Baik; Chris A. Buhr; Sunghoon Ma; John M. Nuss; Zerom Tesfai; Longcheng Wang; Bryan K. S. Yeung


Archive | 2012

Inhibitors of inducible form of 6-phosphofructose-2-kinase

Naing Aay; William Bajjalieh; Ping Huang; Lori Kabigting; Patrick Kearney; Charles K. Marlowe; Kim Moon; John M. Nuss; Arlyn Tambo-Ong; Zerom Tesfai; Amy Lew Tsuhako; Wei Xu; Christiana A. Zaharia


Archive | 2011

Phtalazine derivatives as jak1 inhibitors

Neel Kumar Anand; S. David Brown; Zerom Tesfai; Cristiana A. Zaharia


Archive | 2006

Inhibiteurs de la phosphatidylinositol 3-kinase et procédés pour leur utilisation

William Bajjalieh; Lynne Canne Bannen; S. David Brown; Patrick Kearney; Morrison B. Mac; Charles K. Marlowe; John M. Nuss; Zerom Tesfai; Yong Wang; Wei Xu


Archive | 2006

N-(3-amino-quinoxalin-2-yl)-sulfonamid-derivate und ihre verwendung als phosphatidylinositol-3-kinase-hemmer

William Bajjalieh; Bannen Lynne Canne; S. David Brown; Patrick Kearney; Morrison B. Mac; Charles K. Marlowe; John M. Nuss; Zerom Tesfai; Yong Wang; Wei Xu

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