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Dive into the research topics where S. H. Baik is active.

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Featured researches published by S. H. Baik.


Clinical Endocrinology | 2004

Serum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly Koreans

Kyung Mook Choi; Juneyoung Lee; Kwangyeol Lee; J.A. Seo; Jeong Heon Oh; Suhyun Kim; N.H. Kim; D. S. Choi; S. H. Baik

objective  To determine whether low serum adiponectin concentrations are able to predict the future developments of type 2 diabetes and the metabolic syndrome using the National Cholesterol Education Programme (NCEP) criteria. We also investigated the stability of adiponectin levels and the relationships between baseline adiponectin levels and changes in the parameters related to the metabolic syndrome over a period of 3 years.


International Journal of Obesity | 2008

Relationship between sleep duration and the metabolic syndrome: Korean National Health and Nutrition Survey 2001

Kyung Mook Choi; Jung-Suk Lee; Hae-Sim Park; S. H. Baik; D. S. Choi; Sin-Gon Kim

Objectives:Previous studies have revealed that both short and long sleep durations are linked to obesity, hyperglycemia and hypertension. We evaluate the relationship between sleep duration and the metabolic syndrome using representative national survey data from the Korean population.Methods:We analyzed data from the 2001 Korean National Health and Nutrition Survey. The average amount of sleep per night was categorized as: ⩽5, 6, 7, 8 and ⩾9 h. Those reporting 7 h per night served as a reference group. In this cross-sectional study, the data of 4222 participants were finally analyzed.Results:A majority of the components of the metabolic syndrome demonstrated U-shaped patterns based on sleep duration. Although the prevalences of abdominal obesity and hypertension were highest in subjects who slept ⩽5 h per night, those of hyperglycemia and high triglyceridemia were highest in subjects who slept ⩾9 h per night. Prevalence of the metabolic syndrome also exhibited U-shape pattern based on sleep duration. More components of the metabolic syndrome were highly associated with sleep duration in subjects under the age of 60 compared to those over the age of 60. Subjects who slept ⩽5 h per night demonstrated the highest risk for the metabolic syndrome (OR 1.74, 95% CI 1.33–2.26, P<0.001). Subjects who slept ⩾9 h per night exhibited increased risk for the metabolic syndrome even after adjustment of other risk variables (OR 1.69, 95% CI 1.17–2.45, P=0.006).Conclusions:Both short and long sleep durations are related to increased risk of the metabolic syndrome and its components in the Korean population, although adjustment for risk factors attenuates their relationship. Subjects reporting sleep duration of 7 h demonstrated the lowest prevalence of the metabolic syndrome.


European Journal of Endocrinology | 2008

Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease

Kyung Mook Choi; Jung-Suk Lee; E J Kim; S. H. Baik; Hong-Seog Seo; D. S. Choi; Chulhwan Park

OBJECTIVES Visfatin and lipocalin-2 are novel adipokines associated with insulin resistance (IR) and obesity-related metabolic disorders. We compared lipocalin-2 and visfatin concentrations between patients with coronary heart disease (CHD) and control subjects and evaluated their association with cardiovascular risk factors. METHODS We examined serum visfatin, lipocalin-2 levels, and cardiovascular risk factors in 91 subjects (49 patients with angiographically confirmed CHD versus 42 age- and gender-matched control participants). RESULTS Circulating lipocalin-2 levels were significantly higher in patients with CHD compared with the control subjects (82.6+/-38.7 ng/ml versus 43.8+/-27.8 ng/ml; P<0.001). However, visfatin levels were not significantly different between patients with CHD and control subjects. Serum lipocalin-2 levels were positively associated with weight (r=0.26; P=0.036), fasting insulin (r=0.36; P=0.003), and IR (r=0.33; P=0.007), whereas these levels showed a negative correlation with high-density lipoprotein (HDL) cholesterol (r=-0.30; P=0.016) after adjustment for gender and body mass index. However, visfatin levels were not associated with any variables of the metabolic syndrome. The multiple regression analysis showed that lipocalin-2 levels were independently associated with HDL cholesterol and IR (R2=0.199). Furthermore, the multiple logistic regression analysis showed that systolic blood pressure, IR, and lipocalin-2 levels were independently associated with CHD. CONCLUSIONS Serum lipocalin-2 levels were significantly elevated in patients with CHD and were independently associated with CHD. The present findings suggest that the measurement of serum lipocalin-2 levels may be useful for assessing CHD risk.


The Journal of Clinical Endocrinology and Metabolism | 2011

Serum Selenoprotein P Levels in Patients with Type 2 Diabetes and Prediabetes: Implications for Insulin Resistance, Inflammation, and Atherosclerosis

Sae Jeong Yang; Soon Young Hwang; Hae Yoon Choi; Hye Jin Yoo; J.A. Seo; Suhyun Kim; N.H. Kim; S. H. Baik; D. S. Choi; Kyung Mook Choi

CONTEXT AND OBJECTIVE The dysregulation of hepatokines may be associated with the pathogenesis of insulin resistance and type 2 diabetes. A recent study has suggested that selenoprotein P (SeP), a novel hepatokine, may play a role in the regulation of glucose metabolism and insulin sensitivity. We examined the relationship between circulating SeP levels and clinical parameters associated with insulin resistance in humans. PARTICIPANTS AND METHODS We compared serum SeP concentrations in 100 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the relationship between SeP and cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein, and carotid intima-media thickness. RESULTS Serum SeP concentrations were significantly higher in patients with type 2 diabetes or prediabetes than those with normal glucose tolerance (all P < 0.01) and decreased in a stepwise manner [1032.4 (495.9-2149.4) vs. 867.3 (516.3-1582.7) vs. 362.0 (252.5-694.5), P = 0.004]. In addition, overweight and obese subjects had significantly increased SeP levels compared with lean subjects (P = 0.002). Spearmans partial correlation analysis adjusted for age and gender showed a significant relationship between SeP and cardiometabolic factors including body mass index, waist circumference, systolic blood pressure, triglycerides, glucose, hemoglobin A1c, aspartate aminotransferase, and insulin resistance. Furthermore, in multiple regression analyses, SeP showed an independent association with carotid intima-media thickness as well as high-sensitivity C-reactive protein, even after adjustment for other confounding factors. CONCLUSIONS Circulating SeP concentrations were elevated in patients with glucose metabolism dysregulation and were related to various cardiometabolic parameters including insulin resistance, inflammation, and atherosclerosis.


Diabetic Medicine | 2009

A Ubiquitous Chronic Disease Care system using cellular phones and the internet.

Hye Jin Yoo; M. S. Park; Tae Nyun Kim; Sae Jeong Yang; Geum Ju Cho; Taik Gun Hwang; S. H. Baik; D. S. Choi; G. H. Park; Kyung Mook Choi

Aims  The rapidly increasing prevalence of chronic diseases is an important challenge to healthcare systems worldwide. To improve the quality and efficiency of chronic disease care, we investigated the effectiveness and applicability of the Ubiquitous Chronic Disease Care (UCDC) system using cellular phones and the internet for overweight patients with both Type 2 diabetes and hypertension.


European Journal of Endocrinology | 2007

Effect of exercise training on plasma visfatin and eotaxin levels

Kyung Mook Choi; Jihyun Kim; Geum Ju Cho; S. H. Baik; Hyungchul Park; Sin-Gon Kim

OBJECTIVE Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulin-mimetic effect. Eotaxin, which is an important chemokine in asthma, was recently reported to be associated with obesity in mice and humans. We evaluated the effect of exercise training on plasma visfatin and eotaxin levels in association with cardiovascular risk factors. DESIGN Forty-eight non-diabetic Korean women were evaluated before and after a 12 week exercise program including aerobic exercise (45 min/session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week. RESULTS Plasma visfatin concentrations were elevated in obese subjects (body mass index, BMI> or =25 kg/m2) when compared with non-obese subjects (16.4 +/- 13.4 ng/ml vs 7.7 +/- 5.2 ng/ml, P = 0.006), and eotaxin concentrations were elevated in subjects with central obesity (waist circumference, WC> or =80 cm) when compared with those without central obesity (73.6 +/- 17.8 pg/ml vs 64.2 +/- 4.2 pg/ml, P = 0.005). In multiple regression analyses, visfatin levels were associated with BMI (R2 = 0.255) and eotaxin levels were associated with WC and body weight (R2 = 0.307). After the exercise program, body weight, blood pressure, fasting glucose, and insulin resistance of participants were decreased. Furthermore, plasma visfatin levels were significantly decreased from 13.6 +/- 12.0 to 7.7 +/- 7.9 ng/ml (P = 0.026) and eotaxin levels were reduced from 72.0 +/- 16.7 to 66.9 +/- 14.2 pg/ml (P = 0.018). CONCLUSIONS Exercise training with weight loss induced a significant reduction of plasma visfatin and eotaxin levels in non-diabetic Korean women.


Diabetes Research and Clinical Practice | 2008

Use of a real time continuous glucose monitoring system as a motivational device for poorly controlled type 2 diabetes.

Hye Jin Yoo; Hyonggin An; Soyeon Park; Ohk Hyun Ryu; Honggon Kim; J.A. Seo; Eun-Gyoung Hong; D.H. Shin; Y.H. Kim; Suhyun Kim; Kyung Mook Choi; Inkeun Park; Jae Myung Yu; S. H. Baik

OBJECTIVE The use of a real time continuous glucose monitoring system (RT-CGM) was studied as a behavior modification tool and the effectiveness of a RT-CGM in glucose control for patients with type 2 diabetes was determined. METHODS We conducted a prospective, open-label, randomized, controlled clinical trial in 65 patients with poorly controlled type 2 diabetes (8.0</=HbA1c</=10%) over a 3-month period. The intervention group was monitored monthly with a RT-CGM (three days at a time for 3 months) and the control group continued self-monitoring blood glucose (SMBG) at least four times a week for 3 months. RESULTS The HbA1c of the RT-CGM group was significantly reduced after 12 weeks compared with the SMBG group (9.1+/-1.0% to 8.0+/-1.2% vs. 8.7+/-0.7% to 8.3+/-1.1%, respectively; P=0.004). In the RT-CGM group, there was a significant reduction in total daily calorie intake, weight, body mass index (BMI), and postprandial glucose level, and a significant increase in total exercise time per week after 3 months. CONCLUSIONS We demonstrated that the RT-CGM was useful in modifying a patients diet and exercise habits and could induce better glycemic control than SMBG for patients with type 2 diabetes.


Clinical Endocrinology | 2005

Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity

Sin-Gon Kim; Jung-Suk Lee; Ohk Hyun Ryu; Kwangyeol Lee; Honggon Kim; J.A. Seo; Sin Gon Kim; N.H. Kim; S. H. Baik; Dong Seop Choi; Kyung Mook Choi

Objective  We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients.


Diabetes, Obesity and Metabolism | 2007

Prevalence and trends of metabolic syndrome in Korea: Korean National Health and Nutrition Survey 1998–2001

Hyesoon Park; Sin-Gon Kim; Jung-Suk Lee; Juneyoung Lee; Jun-Soo Han; Dokyung Yoon; S. H. Baik; D. S. Choi; Kyung Mook Choi

Background:  Metabolic syndrome (MetS) is a major international health problem. Limited information is available about the prevalence of MetS in Asia, especially in Korea.


Clinical Endocrinology | 2009

Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women.

Kyung Mook Choi; Tae Nyun Kim; Hye Jin Yoo; Kwangyeol Lee; Geum Ju Cho; Taik Gun Hwang; S. H. Baik; D. S. Choi; Sin-Gon Kim

Objective  Lipocalin family proteins, including adipocyte fatty acid‐binding protein (A‐FABP), lipocalin‐2 and retinol‐binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers.

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