S. Humbert
University of Montpellier
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Featured researches published by S. Humbert.
Autoimmunity Reviews | 2016
J.B. Fraison; P. Sève; Claire Dauphin; Alfred Mahr; E. Gomard-Mennesson; Loig Varron; Grégory Pugnet; Cédric Landron; P. Roblot; Eric Oziol; Gihane Chalhoub; Jean-Marc Galempoix; S. Humbert; Philippe Humbert; E. Sbidian; Florent Grange; Olivier Bayrou; Pascal Cathébras; Philippe Morlat; Olivier Epaulard; Patricia Pavese; Du Le Thi Huong; Abdelkader Zoulim; Katia Stankovic; Hervé Bachelez; Amar Smail; Claude Bachmeyer; Brigitte Granel; Jacques Serratrice; Graziella Brinchault
OBJECTIVE Kawasaki disease (KD) is a vasculitis that mostly occurs in young children and rarely in adults. We analyzed the characteristics of adult-onset KD (AKD) in France. METHODS We collected retrospective and prospective data for patients with a diagnosis of KD occurring after the age of 18 years. Cases were obtained via various French medical networks and identified from the international literature. RESULTS We included 43 patients of AKD at 26 institution from 1992 to 2015, with mean (SD) age 30 (11) years (range 18-68) and sex ratio (M/F) 1.2; 34 patients met the American Heart Association criteria and 9 were incomplete AKD. The median time to diagnosis was 13 days (interquartile range 8-21). The main symptoms were fever (100%), exanthema (98%), changes in the extremities (91%), conjunctivitis (77%), oral cavity changes (89%), cervical adenitis (55%) and cardiac abnormalities (45%). Overall, 35% of patients showed large-vessel vasculitis: coronary vasculitis (26%) and coronary aneurysm (19%). Treatment was mostly intravenous immunoglobulins (79%) and aspirin (81%). Four patients showed myocardial infarction due to coronary vasculitis, but none were treated with IVIg because of late diagnosis. After a median follow-up of 5 months (range 1-117), persistent aneurysm was noted in 9% of cases. Damage was significantly lower with early treatment than late or no treatment (p=0.01). CONCLUSION Given the high frequency of cardiac involvement and complications in this series of AKD, diagnosis and treatment should not be delayed, and early IVIg treatment seems to improve the outcome.
Rheumatology | 2015
S. Humbert; P. Guilpain; Xavier Puéchal; Benjamin Terrier; S. Rivière; Alfred Mahr; Christian Pagnoux; Denis Bagnères; Jean-François Cordier; Alain Le Quellec; Romain Altwegg; Loïc Guillevin
OBJECTIVE Coexistence of ANCA-associated vasculitis (AAV) and IBD is a rare condition that is rarely described in the literature. The aim of the study was to describe the main characteristics of patients presenting with both IBD and AAV. METHODS A retrospective study of AAV patients in the French Vasculitis Study Group cohort who also had a diagnosis of IBD was conducted. We reviewed the medical records and outcomes of these patients. RESULTS We identified 11 patients with AAV and IBD. Four patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss) also had ulcerative colitis and seven patients with granulomatosis with polyangiitis (GPA) had Crohns disease. No Crohns disease was observed in eosinophilic GPA and no ulcerative colitis in GPA. IBD started before AAV manifestations in six cases, simultaneously in two cases and after AAV manifestations in three cases. CONCLUSION Coexistence of IBD and AAV is a rare condition. The therapeutic management of these patients includes corticosteroids in all cases and immunosuppressive drugs in some patients. Coexistence of IBD and AAV might be explained by common underlying inflammatory responses and cytokine profiles polarized towards either Th1 or Th2. Finally, in the presence of digestive manifestations in the context of AAV, the hypothesis of IBD should be assessed.
Archive | 2015
S. Humbert; Philippe Humbert
Protein C and protein S are vitamin K-dependent protein with natural anticoagulant properties that play a major role in the coagulation pathway. Protein C is activated by the thrombin/thrombomodulin complex. Activated protein C cleaves membrane-bound active factors V and VIII and inactivates them. Protein C inhibitor and α-1 antitrypsin are the main inhibitors of protein C. Protein S is a cofactor of activated protein C and can also directly bond to activated factors V and X.
Medicine | 2018
A. Mekinian; Lucas Maisonobe; L. Boukari; Cléa Melenotte; Benjamin Terrier; Xavier Ayrignac; Nicolas Schleinitz; Damien Sene; Mohamed Hamidou; Amadou Konaté; Philippe Guilpain; Noémie Abisror; E. Ghrenassia; Florence Lachenal; Ramiro Cevallos; Richard Roos-Weil; Le Thi Huong Du; François Lhote; Claire Larroche; Jean-François Bergmann; S. Humbert; Jean Baptiste Fraison; J.-C. Piette; Loïc Guillevin; Robin Dhote; Zahir Amoura; Julien Haroche; Olivier Fain
Revue de Médecine Interne | 2017
S. Humbert; K. Bouiller; N. Méaux-Ruault; H. Gil; N. Magy-Bertrand
Revue de Médecine Interne | 2017
H. Gil; P. Tervel; S. Humbert; J. Razanamahery; N. Méaux-Ruault; N. Magy-Bertrand
Revue de Médecine Interne | 2017
J. Razanamahery; S. Humbert; N. Méaux-Ruault; H. Gil; Julien Haroche; J.F. Emile; N. Magy-Bertrand
Revue de Médecine Interne | 2017
P. Naudion; F. Coutier; S. Humbert; N. Méaux-Ruault; K. Bouiller; N. Magy-Bertrand
Revue de Médecine Interne | 2017
F. Coutier; N. Méaux-Ruault; T. Crépin; I. Bedgedjian; E. Muzard; K. Bouiller; H. Gil; S. Humbert; N. Magy-Bertrand
Revue de Médecine Interne | 2017
P. Naudion; K. Bouiller; S. Humbert; H. Gil; N. Méaux-Ruault; M.F. Seronde; N. Magy-Bertrand