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Featured researches published by S. L. Naylor.


Molecular and Cellular Biology | 1984

Regional localization of two human cellular Kirsten ras genes on chromosomes 6 and 12

Alan Y. Sakaguchi; B U Zabel; K H Grzeschik; M L Law; Ronald W. Ellis; Edward M. Scolnick; S. L. Naylor

Human cellular Kirsten ras1 and ras2 genes were localized to chromosomes 6p23 ----q12 and 12p12 .05----pter, respectively, using human-rodent cell hybrids. Thus, the short arms of human chromosomes 11 (encoding lactate dehydrogenase-A and the proto-oncogene c-Ha- ras1 ) and 12 (encoding lactate dehydrogenase B and c-Ki- ras2 ) share at least two pairs of genes that probably evolved from common ancestral genes.


Somatic Cell and Molecular Genetics | 1984

Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

N. K. Honey; Alan Y. Sakaguchi; Peter A. Lalley; Carmen Quinto; Raymond J. MacDonald; Charles S. Craik; Graeme I. Bell; William J. Rutter; S. L. Naylor

The mouse genes for the serine proteases trypsin (Try-1,chymotrypsin B (Ctrb),and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb,and Ela-1was correlated with the segregation of mouse chromosomes. Try-1is located on chromosome 6, Ctrbis on chromosome 8, and Ela-1is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.


Somatic Cell and Molecular Genetics | 1983

Human and mouse cellular myc protooncogenes reside on chromosomes involved in numerical and structural aberrations in cancer 1

Alan Y. Sakaguchi; Peter A. Lalley; S. L. Naylor

A molecular clone of viralmyc (v-myc, the oncogene of avian myelocytomatosis virus, MC29, detected homologous human, mouse, and Chinese hamster cellularmyc (c-myc sequences by Southern filter hybridization. A v-myc probe, containing sequences from the 3′ domain of the gene, hybridized to single human HindIII and mouse EcoRI genomic DNA fragments of the cellular myc genes whose segregation could be followed in interspecies somatic cell hybrids. Human c-myc segregated concordantly with the enzyme marker glutathione reductase and with a karyotypically normal chromosome 8. A rearrangement of human c-myc was observed in Burkitts lymphoma cells possessing the t(8;14) translocation. These results suggest that human c-myc is located close to the breakpoint on chromosome 8 (q24) involved in the t(8;14) translocation. The mouse c-myc gene segregated concordantly with chromosome 15 in mouse-Chinese hamster cell hybrids. These gene assignments are noteworthy, as structural and numerical abnormalities of human chromosome 8 and mouse chromosome 15 are associated frequently with B-cell neoplasms.


Progress in Nucleic Acid Research and Molecular Biology | 1983

A sequence homologous to Rous sarcoma virus v-src Is on human chromosome 20.

Alan Y. Sakaguchi; S. L. Naylor; Thomas B. Shows

Publisher Summary Cellular sequences (c- src ) homologous to the v- src gene of Rous sarcoma virus (RSV) are present in the genomic DNAs of all vertebrates examined and have been evolutionarily conserved. The v- src gene is responsible for the malignant transformation of cells and is expressed as a 60,000-dalton phosphoprotein, designated as pp6Ov-src, with protein kinase activity. Using Southern hybridization techniques and man-mouse somatic cell hybrids, a human c- src gene is assigned to chromosome 20 in the chapter. Cellular DNAs were cut with EcoRI and probed with a 3.1-kb Eco RI DNA fragment containing v- src derived from pSRA-2, a recombinant plasmid containing the genome of the Schmidt–Ruppin A strain of RSV. The v- src gene hybridizes principally to a large Eco RI fragment of human DNA and to two Eco RI fragments of mouse DNA. The presence of additional minor bands that hybridize to v- src suggests that other src -related genes might be present in human and mouse genomes. Human cells contain two related but distinct forms of pp60c-src; however, it is not known whether the two forms are the products of separate c- src genes.


Somatic Cell and Molecular Genetics | 1984

Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase

N. K. Honey; Alan Y. Sakaguchi; Carmen Quinto; R. J. MacDonald; Graeme I. Bell; Charles S. Craik; William J. Rutter; S. L. Naylor

The genes for the serine proteases trypsin, chymotrypsin B, and elastase were chromosomally assigned in man using cDNA probes that have been isolated from a rat pancreatic cDNA library. DNA from human × rodent somatic cell hybrids was cleaved with BamHI or EcoRI and analyzed by Southern filter hybridization methods for the segregation of the genes for trypsin-1 (TRY1), chymotrypsin B (CTRB), and elastase-1 (ELA1). TRY1 was assigned to human chromosome 7q22→qter, CTRB to chromosome 16, and ELA1 to chromosome 12. Although the three genes are members of the same gene family, they are dispersed over different chromosomes.


Cytogenetic and Genome Research | 1986

Mapping of the DNA locus D4S10 and the linked Huntington’s disease gene to 4p16→p15

B U Zabel; S. L. Naylor; Alan Y. Sakaguchi; J. F. Gusella

An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in HindIII-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntingtons disease gene. With in situ hybridization, we mapped D4S10 to the terminal region of the short arm of chromosome 4, localizing the Huntingtons disease gene to bands 4p16----p15. This information may prove useful for the development of strategies to clone the Huntingtons disease gene.


Human Genetics | 1986

Assignment of the gene for carboxypeptidase A to human chromosome 7q22→qter and to mouse chromosome 6

N. K. Honey; Alan Y. Sakaguchi; Peter A. Lalley; Carmen Quinto; William J. Rutter; S. L. Naylor

SummaryA rat cDNA probe for preprocarboxypeptidase A was used to follow the segregation of the human gene for carboxypeptidase A (CPA) in 49 human x mouse somatic cell hybrids using Southern filter hybridization techniques. CPA was assigned to human chromosome 7q22→qter. Similarly, the probe was used to follow the segregation of the mouse gene for carboxypeptidase A (Cpa) in 19 mouse x Chinese hamster somatic cell hybrids. Cpa was assigned to mouse chromosome 6. The gene for carboxypeptidase A forms part of a syntenic group that is conserved in man and mouse.


Nature | 1983

A polymorphic DNA marker genetically linked to Huntington's disease

James F. Gusella; Nancy S. Wexler; P. Michael Conneally; S. L. Naylor; Mary Anne Anderson; Rudolph E. Tanzi; Paul C. Watkins; Kathleen Ottina; Margaret R. Wallace; Alan Y. Sakaguchi; Anne B. Young; Ira Shoulson; Ernesto Bonilla; Joseph B. Martin


Nature | 1984

Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc

Manfred Schwab; Harold E. Varmus; J. Michael Bishop; Karl Heinz Grzeschik; S. L. Naylor; Alan Y. Sakaguchi; Garrett M. Brodeur; Jeffrey M. Trent


Proceedings of the National Academy of Sciences of the United States of America | 1983

High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization.

B U Zabel; S. L. Naylor; Alan Y. Sakaguchi; Graeme I. Bell; Thomas B. Shows

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Alan Y. Sakaguchi

University of Texas Health Science Center at San Antonio

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Thomas B. Shows

Roswell Park Cancer Institute

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B U Zabel

Roswell Park Cancer Institute

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N. K. Honey

Roswell Park Cancer Institute

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Carmen Quinto

National Autonomous University of Mexico

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