S. Mohan

Preliminary immunomodulatory activities of the aqueous extract of Terminalia chebula

ABSTRACT Terminalia chebula. (Gaertn.) Retz. (Combretaceae), a plant widely used in the traditional medicinal systems of India, has been reported to possess antibacterial, laxative, antioxidant, and diuretic activities. In the current study, the aqueous fruit extract of Terminalia chebula. has been investigated for its effect on cell-mediated and humoral components of the immune system in mice. Administration of Terminalia chebula. extract produced an increase in humoral antibody (HA) titer and delayed-type hypersensitivity (DTH) in mice. It was concluded that the Terminalia chebula. extract is a promising drug with immunostimulant properties.

Synthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents.

A series of 3-substituted amino-4,5-tetramethylene thieno[2,3-d] [1,2,3]-triazine-4(3H)-ones have been synthesized and characterized by UV,IR, 1H NMR, elemental and mass spectral analysis. The title compounds were evaluated for their antimicrobial activity by agar diffusion method against four bacteria and three fungi using Ampicillin and Miconazole nitrate as standards. The compounds VIIIa, IXa, Xa and XIa showed an antimicrobial efficacy considerably greater than the compounds Ia to VIIa with -H, phenyl and electron donating (activating) groups like methyl, ethyl and tolyl substitutions at R, suggesting that lipophillic groups like chloro, fluoro substitution on the phenyl ring plays an important role in enhancing the antimicrobial properties of this class of compounds. From the screening results it can be concluded that the compounds having the lipophillic groups like chlorophenyl and fluorophenyl groups at R exhibited appreciable antimicrobial activities. Whereas, the compounds are having -H, phenyl and electron donating (activating) groups like methyl, ethyl and tolyl substituents at R were less active against all the organisms used.

Syntheses, Characterization and In-Vitro Anti-Inflammatory Activity of Some Novel Thiophenes

Abstract Aim: The present study was aimed to synthesize a series of 2-substituted benzylidine imino-3-(3-chloro- 4-fluorophenyl)-carboxamido-4,5-trimethylene thiophenes SPJ-1(a-m) and to evaluate their in-vitro anti-inflammatory activity. Materials and Methods: The starting material (SPJ-1) was prepared by the application of versatile Gewald reaction. The In-vitro anti-inflammatory activity of synthesized compounds [SPJ-1(a-m)] was evaluated using inhibition of bovine serum albumin denaturation method. Result: SPJ-1b and SPJ-1g have shown significant in-vitro anti-inflammatory activity. Conclusion: The findings of the present study clearly demonstrate that chloro functional group possess inhibition of bovine serum albumin denaturation capacity and has in-vitro anti-inflammatory activity. However hydroxyl, nitro, methyl, methoxy and dimethyl amino derivatives did not show any in-vitro antiinflammatory activity.

Anti-inflammatory and Antipyretic Activity of Decalepis hamiltonii. Root Extract

Abstract Decalepis hamiltonii Wight & Arn. (Asclepiadaceae) is widely used in the traditional system of medicine for many ailments. We examined the effectiveness of the methanol extract of roots of Decalepis hamiltonii at 250 and 500 mg/kg doses orally in the carrageenan-induced rat paw edema and cotton pellet–induced chronic inflammatory models. The extract showed significant dose-dependent anti-inflammatory activities in both models. The extract exhibited significant antipyretic activity at 250 and 500 mg/kg, p.o., in brewers yeast–induced pyrexia.

Methyl 2-(acetylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

The title compound, C12H15NO3S, exhibits antibacterial and antifungal activities. The cyclohexene ring exhibits disorder,indicating two possible conformations of the half-chair form.The molecular structure is approximately planar, supported byan intramolecular N–H...O hydrogen bond.

2-Amino-N-(2-chlorophenyl)-4,5,6,7-tetra-hydro-1-benzothiophene-3-carboxamide

The title compound,

Two biologically active thiophene- 3-carboxamide derivatives

{C_{15}H_{15}ClN_{2}OS}

Synthesis, Characterization and Anti-Inflammatory Activity of Some Schiff bases of 4-Amino-5,6-Dimethyl thieno [2,3-d] Pyrimidines

, shows antibacterial and antifungal activities. The dihedral angle between the thiophene moiety and the 2-chlorophenyl ring is

Synthesis, Characterization of Some Novel Heterofused Thienopyrimidines for Anti-Inflammatory Activity

22.3(1)^{\mathtrm{0}}

4,5-Dimethyl-N-(2-methylphenyl)-2-

. There are intramolecular N–H...O and N–H... Cl hydrogen bonds and an intramolecular C–H...O interaction, which remove the conformational fexibility. Also intermolecular N–H...Ointeractions form chains of molecules in the crystal structure.