S. Ridolfi

Design of compact pinhole SPECT system based on flat panel PMT

The present development of new gamma imagers has allowed to realize detectors with ultra high spatial resolution and very compact size for PET as well as for SPET application. In this paper we analyze and discuss the possible design of new pinhole SPECT scanners based on heads which consist of flat panel PSPMT and different design of scintillation arrays like NaI(Tl), 1 mm pixel size, and CsI(Tl) multi layers array, mounted in off centered configuration to improve the intrinsic spatial resolution of the imagers. The results show that an array configuration 2/spl times/2 Hamamatsu flat panel PSPMTs coupled to NaI(Tl) scintillation array with 1 mm pixel size, represents the best trade off between compactness and spatial resolution of pinhole SPET scanner. The use of off centered CsI(Tl) scintillation array coupled to a single flat panel PSPMT allows to arrange a high sensitivity and very compact pinhole SPET scanner at very low cost only worsening of 50% spatial resolution than an Anger gamma camera pinhole SPECT.

New devices for imaging in nuclear medicine.

Pinhole gamma camera imaging offers the ability to obtain high resolution images from single gamma ray emitting radiotracers playing a reasonable tradeoff between very small field of view (FoV) and sensitivity. On the other hand the total spatial resolution of a pinhole imaging device is predominantly affected by the detector intrinsic spatial resolution for reduced magnification factors. To design very compact pinhole SPET scanners with very high intrinsic spatial resolution, authors investigated a miniature gamma camera based on the newly developed Hamamatsu H8500 flat panel photomultiplier. The PSPMT was coupled to the following scintillation arrays: CsI(Tl) array with 0.2-mm, 1-mm, 1.4-mm pixel size and NaI (Tl) with 1-mm pixel size. The imaging performances were evaluated by 57Co spot and flood irradiations. NaI(Tl) array shows a better pixel identification for 1 mm pixel size, proving to be a good candidate to make a large area photodetector based on multi PSPMTs closely packed. Although CsI(Tl) array had the smallest pixel size, the low light output limited the best intrinsic spatial resolution to about 0.5 mm.

Evaluation of flat panel PMT for gamma ray imaging

Abstract The first position sensitive PMT, Hamamatsu R2486, developed in 1985, represented a strong technological advance for gamma-ray imaging. Hamamatsu H8500 Flat Panel PMT is the last generation position sensitive PMT: extremely compact with 2 in. active area. Its main features are: minimum peripheral dead zone (1 mm ) and height of 12 mm . It was designed to be assembled in array to cover large detection area. It can represent a technical revolution for many applications in the field of gamma-ray imaging as for example nuclear medicine. This tube is based on metal channel dynode for charge multiplication and 8×8 anodes for charge collection and position calculation. In this paper we present a preliminary evaluation of the imaging performances addressed to nuclear medicine application. To this aim we have taken into account two different electronic readouts: resistive chain with Anger Camera principle and multianode readout. Flat panel PMT was coupled to CsI(Tl) and NaI(Tl) scintillation arrays. The results were also compared with the first generation PSPMT.

Factors affecting flat panel PMT calibration for gamma ray imaging

Hamamatsu H8500 Flat Panel PMT represents the last technological advancement in gamma ray imaging. Compact size makes it attractive for medical imaging application. To study and compare image performance two Flat Panel PMTs were coupled to CsI(Tl) and NaI(Tl) scintillation arrays with 3 mm and 1.8 mm pixel size respectively and they were connected to multi-anode electronic readout (64 channel). Furthermore a pulsed blue LED coupled to an optical fiber was utilized to scan the tube with different light distribution spreading. The study took into account how PMT anode gain uniformity response, light distribution and intensity, influence spatial resolution, position linearity and image noise. Gain calibration was firstly studied because of PMT gain anode non uniformity response, which range between 27:100 and between 45:100 respectively. Furthermore each crystal pixel produces different charge distribution and this depends on the matching between anode and scintillation array lattice. The amount of anode charge can change more than a factor five for narrow light distributions. Tube gain setting results critical, in fact because of energy resolution of each anode spectra, only a factor five pulse height variation can be adequately converted by ADC. In addition there is a further gain anode variation due to PMT non uniformity response of a factor 3. This mentioned two elements, do not allow to convert all pulses in the useful pulse height ADC range. As a consequence image position distortion and background are produced. Flat Panel shows good image performance. However, because of the big anode size and PMT gain non uniformity response, the gain setting can be critical to obtain the best image performance for scintillation light distribution comparable with anode size.

A novel parallel hole collimator for high resolution SPET imaging with a compact LaBr3 gamma camera

In this work we propose an analysis of a novel Low Energy (LE) parallel hole collimator for high resolution single photon emission tomography (SPET) applications. This prototype, realized jointly with Nuclear Fields, is a lead parallel hole collimator with 1.0 mm hexagonal hole, 18 mm length, 0.2 mm septa and 10x10 cm2 of useful detection area. It has been planned to match the high spatial resolution performances of a compact gamma camera based on LaBr3:Ce continuous scintillation crystal. The imaging performances of this prototype are compared with others two parallel collimators, for different dimensions and applications, and a tungsten pinhole collimator ones. All the collimators were tested with a compact scintillation gamma camera based on LaBr3:Ce continuous crystal and multi anode photomultipler tube (MA-PMT) Hamamatsu H8500. The high intrinsic spatial resolution of this crystal enhances the response of collimators at short source-to-collimator distance (SCD) overcoming alignment problems with the collimator pattern. From our analysis the collimator prototype seems to be complementary with the use of pinhole one and when coupled to the compact LaBr3:Ce gamma camera can allow a very attractive trade-off between spatial resolution, sensitivity and detection area for radionuclide molecular imaging applications.

CsI(Tl) Micro-Pixel Scintillation Array for Ultra-high Resolution Gamma-ray Imaging

The aim of this paper is to investigate the intrinsic spatial resolution limit by coupling a CsI(Tl) micro-pixel scintillation array to position sensitive photomultipliers (PSPMTs) for ultra-high resolution gamma-ray imaging. On this purpose, 1 mm thick array with 0.2 mm pixel side, 0.4 mm pitch has been realized by Spectra Physics (Hilger). The present scintillation arrays technology is suitable to produce larger crystal areas. In this paper we present spatial resolution and positioning results obtained by coupling the micro-pixel scintillation array to Hamamatsu square PSPMTs: 1rdquo R8520-C12, 1rdquo R5900-L16 and 2rdquo H8500 Flat panel PMT. Preliminary measurements demonstrate better performance in term of uniformity response when micro-pixel array is coupled to a H8500 PSPMT model. This setup carries out an intrinsic spatial resolution lower limit of about 0.6 mm FWHM at 50% FWHM energy resolution, defining it as the minimum scintillation array pitch detectable at 122 keV. The results obtained by R5900-L16 with a better sampling of the scintillation light has shown an improvement of the position linearity in spite of a worse spatial resolution due to the poor light output of scintillation array.

Imaging characteristics comparison of compact pixellated detectors for scintimammography

Although scintimammography is routinely used in the hospitals it had not the expected large diffusion. The low specificity of SESTAMIBI /sup 99m/Tc and the geometrical restrictions of prone scintimammography further contributed in limiting the clinical sensitivity for sub centimeter lesions. Researchers aware that to overcome intrinsic limitation of radio-pharmaceutical, they are optimized compact imager able to detect small amount of radioactivity emitted from 5 mm or less tumors. To investigate the overall imaging characteristics of scintillation imagers for scintimammography, a number of small gamma camera prototypes were assembled, based on PSPMT of first and last generation. They were coupled to a number of NaI(Tl) and CsI(Tl) scintillation both planar and pixellated, with different pixel size. Measurements were performed by line and circular source as well as by 3 mm to 10 mm diameter tumor phantoms. Spatial resolution seems the dominant factor, in detection of 5 mm and 3 mm tumor size. The best results were obtained from the scintillation crystals arrays coupled to Hamamatsu flat panel PMT. Decreasing crystal pixel size, contrast mean values slightly changed but their accuracy increases, demonstrating the influence of digitization on image quality. MTF curve obtained by planar NaI(Tl) integral assembly shows an improvement with a response at the highest frequency equal to one obtained from collimator parallel hole Monte Carlo simulation.

Factors Affecting Hamamatsu H8500 Flat Panel PMT Calibration for Gamma Ray Imaging

The Hamamatsu H8500 Flat Panel PMT is the latest technological advancement in gamma ray imaging. Its compact size makes it attractive for medical imaging applications. To study and compare image performance a Flat Panel PMT, representing the present production, was coupled to CsI(Tl) and Nal(Tl) scintillation arrays with 3 mm and 1.8 mm pixel size respectively and connected to a multi-anode electronic readout. Furthermore, a pulsed blue LED coupled to an optical liber was utilized to scan the tube with different light distributions. This study investigated how PMT anode gain uniformity response, scintillation light distribution and intensity influence the spatial resolution, the position linearity and the image noise. Each crystal in the scintillation array produces a different charge distribution, which depends on the match between the anode size and the scintillation array lattice. The Nal(Tl) array demonstrated to fit both PMT characteristics and dynamic range of electronic read out, due to the charge distribution adequate to the anode size. For CsI(Tl) crystal, the pulse height calibration resulted more critical, due to the narrow light distribution. In conclusion, the use of Flat Panel tube with selected anode gain uniformity could represent the cheapest and easiest solution to obtain the best image quality, in particular for scintillator array with smaller pixel size.

Iodine 125 Imaging in Mice Using NaI(Tl)/Flat Panel PMT Integral Assembly

Radiolabeled agents that bind to specific receptors have shown great promise in diagnosing and characterizing tumor cell biology. A second area of interest is in vivo imaging of gene transcription and protein expression. The radioisotope I/sup 125/ is commercially available as a label for molecular probes and utilized by researchers in small animal studies. We propose an advanced imaging detector based on planar NaI(TI) integral assembly with a Hamamatsu Flat Panel PMT, representing one of the best trade-off between spatial resolution and detection efficiency. We tested the in-vivo performance of the detector by acquiring images of mice as a part of a study of inflammatory bowel disease (IBD). In this study, four 25 g mice with an IBD-like phenotype (SAMPl/YitFc) were injected with 375, 125, 60 and 30 /spl mu/Ci of /sup 125/I-labelled antibody against MAdCAM-1, a gut-specific endothelial cell adhesion molecule that is up-regulated in the presence of inflammation. Two mice without bowel inflammation were injected with 150 and 60 /spl mu/Ci of the labelled anti-MAdCAM-1 antibody as controls. To better evaluate the performances of the integral assembly detector, we also acquired mice images with a dual modality (X and Gamma Ray) camera dedicated for small animal imaging. The results of this new detector are impressive: images of SAMP1/YitFc injected with 30 /spl mu/Ci activity show inflammation throughout the intestinal tract, with the disease very well defined at two hours post-injection.

Flat Panel PMT: advances in position sensitive photodetection

Abstract Over the last ten years there was being a strong advancement in photodetection. Different application fields are involved in their use in particular high energy physics, astrophysics and nuclear medicine. They usually work by coupling a scintillation crystal and more recent scintillation arrays with pixel size as small as 0.5 mm. PSPMT represents today the most ready technology for photodetection with large detection areas and very high spatial resolution. Flat panel PMT represents the last technological advancement. Its dimension is 50x50 mm 2 with a narrow peripheral dead zone (0.5 mm final goal). Its compactness allow to assemble different modules closely packed, achieving large detection areas with an effective active area of 97%. In this paper we analyze the imaging performances of PSPMT by coupling two scintillation arrays and by light spot scanning of photocathode to evaluate the linearity position response, spatial resolution and uniformity gain response as a function of light distribution spread and the number of photoelectrons generated on photocathode. The results point out a very narrow PMT intrinsic charge spread and low cross-talk between anodes. Energy resolution and spatial resolution show a good linearity with DRF variation. An unexpected intra-anode gain variation is carried out. In this paper we present the results obtained with this PSPMT regarding imaging performances principally addressed to nuclear medicine application.