S. Tsuchiya

Intestinal responses to hyperosmolar glucose infusion in dogs.

SummaryPhysiological and morphological changes of small intestine after hyperosmolar glucose infusion into canine jejunum were studied using in vivo perfusion model.Infusion of 40 ml of 50% and 20% glucose solution into the jejunal loops induced biphasic osmolar degression in the lumen. Osmolarity of jejunal venous blood was rapidly increased and maintained the maximal level (approximately 320 mOM/L).Blood flow to the jejunal loop was significantly increased after 50% glucose infusion compared to 5% glucose infusion.Most characteristic electron microscopic change of jejunal epithelial cell was pseudo-pod like process projected into the jejunal lumen, which was very similar to that of cholera.