Sabina Pecchi

Stannylcupration of γ-heterosubstituted acetylenic esters: A new route to 4-stannylated five membered N- and O- heterocycles

Abstract 4-Tributylstannyl,2-(5H)-furanone and pyrrolone have been prepared in good yields by addition of mixed stannylcuprate reagent on γ-amino and γ-hydroxy acetylenic esters. The use of these compounds as useful intermediates for the selective functionalization of these heterocyclic rings is discussed.

A stereoselective approach to the synthesis of aminoalcohols

Abstract Amino alkoxy oxiranes have been isomerized to stereochemically pure amino alcohols, useful precursors for dipeptides isosteres, by treatment with the superbasic mixture butyllithium/ diisopropylamine/ potassium tert-butoxide.

A short synthesis of rigid 2-alkylthio-2,2-diaryl substituted acetic acids

Abstract The metalation of rigid diphenyl methane derivatives has been studied, aiming at the synthesis of 2-alkylthio-2,2-diaryl substituted acetic acids esters, a class of compounds with a potential antimuscarinic activity. Mixed metal bases have shown to be necessary in order to obtain the desired compounds with a good regiocontrol.

The synthesis of 4′-thia-α-santalene and 4′-thia-α-santalol through an organometallic approach

Abstract The 4′-thia analogues of α-santalene and α-santalol are prepared in a very convenient, regio- and stereocontrolled manner by using allyl type organometallic intermediates.