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Featured researches published by Sachiko Koike.


Radiation Research | 1990

Frequency of micronuclei in hepatocytes following X and fast-neutron irradiations--an analysis by a linear-quadratic model.

Koji Ono; Yasushi Nagata; Keizo Akuta; Mitsuyuki Abe; Koichi Ando; Sachiko Koike

The usefulness of the micronucleus assay for investigating the radiation response of hepatocytes was examined. The frequency was defined as the ratio of the total number of micronuclei to the number of hepatocytes examined. The dose-response curves were curvilinear after X rays and linear after neutrons. These dose-response curves were analyzed by a linear-quadratic model, frequency = aD + bD2 + c. The a/b ratio was 3.03 +/- 1.26 Gy following X irradiation. This value is within the range of the alpha/beta ratios reported by others using the clonogenic assay of hepatocytes. While the a/b value for neutrons was 24.3 +/- 11.7 Gy, the maximum relative biological effectiveness of neutrons was 6.30 +/- 2.53. Since the micronucleus assay is simple and rapid, it may be a good tool for evaluating the radiation response of hepatocytes in vivo.


Archive | 2014

Poster Session 10: Biological effectiveness of Particle Therapy Fractionated irradiation of carbon beam and the isoeffect dose on acute reaction of skin

Akiko Uzawa; Ryoichi Hirayama; Yoshitaka Matsumoto; Kana Koda; Sachiko Koike; Koichi Ando; Yoshiya Furusawa


The Japan Radiation Research Society Annual Meeting Abstracts The 52nd Annual Meeting of the Japan Radiation Research Society | 2009

Effects of carbon-ion radiation on heterogeneous tumors---Comparison between combinations

Sachiko Koike; Koichi Ando; Akiko Uzawa; Yoshiya Furusawa; Ryoichi Hirayama; Yoshitaka Matsumoto; Mitsuaki Yoshida; Ryuichi Okayasu


The Japan Radiation Research Society Annual Meeting Abstracts The 52nd Annual Meeting of the Japan Radiation Research Society | 2009

The effects of heavy-ion and photon beams to mouse malignant melanoma cell line having high metastatic potential

Yoshitaka Matsumoto; Sachiko Koike; Akiko Uzawa; Ryoichi Hirayama; Sei Sai; Nobuhiro Takase; Koichi Ando; Ryuichi Okayasu; Yoshiya Furusawa


The Japan Radiation Research Society Annual Meeting Abstracts The 47th Annual Meeting of The Japan Radiation Research Society | 2004

Inhibition by antibody-administration of radioresistance induced by low-LET carbon ions

Koichi Ando; Akiko Uzawa; Nobuhiko Takai; Sachiko Koike; Takeshi Fukawa; Yoshiya Furusawa; Ryoichi Hirayama; Mizuho Aoki; Yoshitaka Matsumoto; Yasuyuki Miyato


The Japan Radiation Research Society Annual Meeting Abstracts The 46th Annual Meeting of The Japan Radiation Research Society | 2003

Relationship between RBE values of Carbon Ion and Tumor Growth Rate (Part2)

Sachiko Koike; Koichi Ando; Akiko Uzawa; Yoshiya Furusawa; Nobuhiko Takai; Takeshi Fukawa; Mizuho Aoki; Manami Monobe; Yasuyuki Miyato; Sinichiro Satoh


The Japan Radiation Research Society Annual Meeting Abstracts The 46th Annual Meeting of The Japan Radiation Research Society | 2003

Significance of beta term in carbon-ion radiotherapy

Koichi Ando; Akiko Uzawa; Takeshi Fukawa; Nobuhiko Takai; Mizuho Aoki; Sachiko Koike; Yoshiya Furusawa; Yasuyuki Miyato; Manami Monobe; Guangming Zhou


Archive | 2003

Radioresistance of mouse intestine induced by carbon-ion irradiation

Akiko Uzawa; Koichi Ando; Takeshi Fukawa; Mizuho Aoki; Nobuhiko Takai; Yasuyuki Miyato; Guangming Zhou; Sachiko Koike


The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME | 2001

Effect of distribution of tumor vasculature and pO_2 in radiation therapy

Takeshi Fukawa; Kyoji Honma; Takehiko Satoh; Kotaro Oka; Sachiko Koike; Koichi Ando; Kazuo Tanishita


Radiation Research: A Twentieth-century Perspective#R##N#Congress Abstracts | 1991

P09 10 SP – ENHANCED SIDE EFFECTS OF SPINAL CORD IRRADIATION IN INFANTILE MICE BY CHEMOTHERAPEUTIC AGENTS

Mayumi Iwakawa; Koichi Ando; Sachiko Koike

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Akiko Uzawa

National Institute of Radiological Sciences

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Yoshiya Furusawa

National Institute of Radiological Sciences

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Takeshi Fukawa

National Institute of Radiological Sciences

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Mizuho Aoki

National Institute of Radiological Sciences

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Nobuhiko Takai

National Institute of Radiological Sciences

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Manami Monobe

Tokyo University of Science

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