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Featured researches published by Sachin Kedar.


Neurology | 2006

Natural history of homonymous hemianopia.

X. Zhang; Sachin Kedar; Michael J. Lynn; Nancy J. Newman; Val rie Biousse

Objective: To describe the characteristics of spontaneous recovery of homonymous hemianopia (HH). Methods: The authors reviewed medical records of all patients with HH confirmed by formal visual field testing and seen in follow-up in their service between 1989 and 2004. Clinical characteristics, causes, neuroradiologic definition of lesion location, final outcome, and evolution of the visual field defects were recorded. The associations among final visual field defect outcome, time from injury, and clinical features were analyzed. Results: A total of 254 patients with 263 HH were included in this study. Spontaneous visual field defect recovery was observed in 101 HH (38.4%). The likelihood of spontaneous recovery decreased with increasing time from injury to initial visual field testing (p = 0.0003). The probability of improvement was related to the time since injury (p = 0.0003) with a 50 to 60% chance of improvement for cases tested within 1 month after injury that decreased to about 20% for cases tested at 6 months after surgery. No other factor was found to correlate with the final outcome of the visual field defects. Improvement after 6 months from injury was mild and usually related to improvement of the underlying disease. Conclusion: Spontaneous improvement of homonymous hemianopia is seen in at least 50% of patients first seen within 1 month of injury. In most cases, the improvement occurs within the first 3 months from injury. Spontaneous improvement after 6 months postinjury should be interpreted with caution as it is most likely related to improvement of the underlying disease or to improvement in the patient’s ability to perform visual field testing reliably.


Neurology | 2006

Homonymous hemianopias Clinical–anatomic correlations in 904 cases

X. Zhang; Sachin Kedar; Michael J. Lynn; Nancy J. Newman; Val rie Biousse

Objective: To describe the clinical characteristics and clinical-anatomic correlations of homonymous hemianopia (HH). Background: Homonymous hemianopia impairs visual function and frequently precludes driving. Most knowledge of HH is based on relatively few cases with clinical-anatomic correlations. Methods: The authors reviewed medical records of all patients with HH seen in their service between 1989 and 2004. Demographic characteristics, characteristics of visual field defects, causes of visual field defects, neuroradiologic definition of lesion location, and associated neurologic deficits were recorded. Results: A total of 904 HH were found in 852 patients. A total of 340 HH (37.6%) were complete and 564 HH (62.4%) were incomplete. Homonymous quadrantanopia (264 HH, 29%) was the most common type of incomplete HH, followed by homonymous scotomatous defects (116 HH, 13.5%), partial HH (114 HH, 13%), and HH with macular sparing (66 HH, 7%). A total of 407 HH (45.0%) were isolated. Causes of HH included stroke (629 HH, 69.6%), trauma (123, 13.6%), tumor (102, 11.3%), brain surgery (22, 2.4%), demyelination (13, 1.4%), other rare causes (13, 1.4%), and unknown etiology (2, 0.2%). The lesions were most commonly located in the occipital lobes (45%) and the optic radiations (32.2%). Every type of HH, except for unilateral loss of temporal crescent and homonymous sectoranopia, was found in all lesion locations along the retrochiasmal visual pathways. Conclusion: Homonymous hemianopia is usually secondary to stroke, head trauma, and tumors. Although the characteristics of visual field defects can be helpful in lesion location, specific visual field defects do not always indicate specific brain locations.


Journal of Neuro-ophthalmology | 2006

Homonymous hemianopia in stroke.

X. Zhang; Sachin Kedar; Michael J. Lynn; Nancy J. Newman; Valérie Biousse

Background: Previous reports have suggested that most cases of homonymous hemianopia (HH) are caused by occipital stroke. However, these reports have not always been supported by brain imaging. Methods: We reviewed the medical records of all patients seen in our unit between 1989 and 2004 who had HH documented by formal perimetry or confrontation visual fields and had undergone brain imaging. HHs were divided into those caused by stroke and by non-stroke conditions. The clinical and visual field characteristics were compared in the two groups. Results: Among 850 patients with 902 HHs, 629 (69.7%) resulted from stroke, of which 531 (84.4%) were from infarction and 98 (15.6%) from primary intraparenchymal hemorrhage. Non-stroke causes included head trauma (123), brain tumor (102), neurosurgical procedures (22), multiple sclerosis (13), and miscellaneous conditions (13). Occipital lesions most commonly resulted from stroke. The configuration of the HH did not predict where in the retrochiasmal visual pathway the responsible lesion lay. Conclusions: Ischemic stroke causes most HHs from lesions in the occipital lobe that generally do not produce other neurologic manifestations. The configuration of the HH does not predict the location of the lesion within the retrochiasmal visual pathway.


Neurobehavioral HIV Medicine | 2012

The neuro-ophthalmology of HIV-AIDS review of Neurobehavioral HIV Medicine

Padmaja Sudhakar; Sachin Kedar; Joseph R. Berger

Correspondence: Sachin Kedar Department of Neurology L445 Kentucky Clinic, 740 South Limestone Street, Lexington, KY 40536-0284, USA Tel 859-218-5035 Fax 859-323-5943 Email [email protected] Abstract: Neuro-ophthalmic problems are known to occur both in human immunodeficiency virus (HIV) infection and AIDS. Central nervous system (CNS) opportunistic infections and malignancies such as lymphoma are the major source of these problems but some result from the direct effect of the virus on the CNS. Both the afferent visual pathway and efferent ocular motor system may be affected. Neuro-ophthalmic signs may sometimes be the initial manifestation of AIDS. A variety of neuro-ophthalmic manifestations may be encountered in the same patient. Several large studies on the ophthalmic features of AIDS have included neuroophthalmic manifestations in their series. However dedicated comprehensive review articles on this subject are few. Despite the introduction of highly active antiretroviral therapy (HAART), neuro-ophthalmic manifestations still remain a problem in HIV. The aim of this article is to provide an overview of the neuro-ophthalmic sequelae of AIDS.


American Journal of Ophthalmology | 2006

Traumatic homonymous hemianopia

Beau B. Bruce; X. Zhang; Sachin Kedar; Nancy J. Newman; Val rie Biousse

OBJECTIVE To describe the characteristics of patients with homonymous hemianopia from traumatic brain injury (TBI) seen in our unit between 1989 and 2004. METHODS Only patients with a history of TBI, who had detailed clinical information and results of neuroimaging, were included in our study. Demographic characteristics, clinical features, types of visual field defects, location of lesion and evolution of visual field defects were recorded. RESULTS Of the 880 patients with homonymous hemianopia seen in our unit, 103 patients (112 with homonymous hemianopia) had TBI (74 men and 29 women, mean age 30.7 (SD 15.3) years). Median time from injury to initial visual field testing was 5 (range 0.5-360) months. In all, 64 (57.1%) patients sustained injuries that were motor vehicle-related; 19 (17%) violence-related; 17 (15.2%) due to falls; and 12 (10.7%) because of other blunt head trauma. Visual field defects included complete homonymous hemianopia in 44 (39.3%) patients and incomplete homonymous hemianopia in 68 (60.7%) patients. The lesion was occipital in 14 (12.5%) patients, associated with optic radiation in 26 (23.2%) and the optic tract in 12 (10.7%), and multiple in 60 (53.6%). CONCLUSION Most cases of homonymous hemianopia from TBI were motor vehicle-related. Patients were younger, more often male, and had multiple brain lesions more often than patients with homonymous hemianopia from causes other than TBI. A median delay of 5 months was observed before the documentation of the homonymous hemianopia, which may have a major effect on the success of rehabilitation and driving training in these young patients.


American Journal of Ophthalmology | 2007

Congruency in Homonymous Hemianopia

Sachin Kedar; X. Zhang; Michael J. Lynn; Nancy J. Newman; Valérie Biousse


Journal of Aapos | 2006

Pediatric Homonymous Hemianopia

Sachin Kedar; X. Zhang; Michael J. Lynn; Nancy J. Newman; Valérie Biousse


Journal of Neuro-ophthalmology | 2005

Simultaneous bilateral retinal artery occlusions associated with a mitral valve mass.

Sachin Kedar; Valérie Biousse; Nancy J. Newman


Journal of Neuro-ophthalmology | 2018

Should Antiviral/Anti-Varicella Zoster Virus Treatment Be Used in Patients With Giant Cell Arteritis?

Yaping Joyce Liao; Sachin Kedar


Journal of Neuro-ophthalmology | 2018

Neurological and Ophthalmological Manifestations of Varicella Zoster Virus

Sachin Kedar; Lakshman N. Jayagopal; Joseph R. Berger

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