Sachin S. Patil

Simple and Efficient One-Pot Synthesis of 2-Substituted Benzoxazole and Benzothiazole

2-Substituted benzoxazole and benzothiazole were synthesized from condensation of aldehyde and 2-aminophenol or 2-aminothiophenol via a one-pot process using diethyl bromo phoshonate and tert-butyl hypochlorite.

N-Chlorosuccinimide/1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)–Mediated Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles

A mixture of N-chlorosuccinimide and 1,8-diazabicyclo[5.4.0]undec-7-ene oxidatively cyclizes structurally diverse acyl hydrazone, thereby providing an efficient and convenient method for the synthesis of various 2,5-disubstituted 1,3,4-oxadiazoles. The salient features of this method are mild reaction conditions, short reaction time, excellent yields, and simple workup procedure.

An Efficient Synthesis of Zolpidem

Imidazo[1,2-a]pyridines (IPs) have received considerable attention because of their interesting therapeutic properties,1 including antibacterial,2 antifungal,3,4 antiviral,5,6 antiulcer,7 and anti-inflammatory behavior.8 They have also been identified as selective cyclin-dependent kinase inhibitors,9 calcium channel blockers,10 β-amyloidal formation inhibitors,11 and benzodiazepine receptor agonists,12 and constitute a novel class of orally active nonpeptidic bradykinin B2 receptor antagonists.13 Drug formulations containing imidazo[1,2a]pyridines such as alpidem (anxolytic), zolpidem (hypnotic), and zolimidine (antiulcer) are currently marketed.

A facile route for the synthesis of vinyl-substituted 1,3,4-oxadiazoles

An efficient synthesis of vinyl-substituted 1,3,4-oxadiazoles using o-nitrophenyl sulfoxide precursor via syn-elimination reaction using sodium acetate in THF is described. This method is cost effective as it uses cheap o-nitrothiophenol and can be used in the synthesis of vinyl intermediates during synthesis of bioactive compounds, which avoids the use of any toxic metals.