Sachin V. Patil

Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives.

A series of novel hybrid molecules 4a-y containing thiazole and benzotriazole templates were designed and synthesized. The structures of the synthesized compounds were elucidated by IR, (1)H NMR, (13)C NMR and mass spectral data. All the synthesized compounds were tested for their antimicrobial activity (zone of inhibition) against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. After that minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs) and minimum fungicidal concentrations (MFCs) of all the synthesized compounds were determined. The investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good microbial inhibitions.

Hybrids of ravuconazole: Synthesis and biological evaluation

In continuation of our work on antimicrobial agents, a number of hybrid molecules 4a-y containing thiazole and triazole pharmacophores were designed and synthesized. The structure of the compounds was established by IR, NMR, MS and CHN analysis. All the synthesized compounds were tested for qualitative (Zone of inhibition) and quantitative (MIC) antimicrobial activities against four pathogenic bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa and two pathogenic fungi Candida albicans and Aspergillus niger. Of all the synthesized compounds screened, most of them show potent antimicrobial activity against Gram positive and Gram negative bacteria as well as the fungi species.

An Efficient Synthesis of Zolpidem

Imidazo[1,2-a]pyridines (IPs) have received considerable attention because of their interesting therapeutic properties,1 including antibacterial,2 antifungal,3,4 antiviral,5,6 antiulcer,7 and anti-inflammatory behavior.8 They have also been identified as selective cyclin-dependent kinase inhibitors,9 calcium channel blockers,10 β-amyloidal formation inhibitors,11 and benzodiazepine receptor agonists,12 and constitute a novel class of orally active nonpeptidic bradykinin B2 receptor antagonists.13 Drug formulations containing imidazo[1,2a]pyridines such as alpidem (anxolytic), zolpidem (hypnotic), and zolimidine (antiulcer) are currently marketed.

Synthesis and biological evaluation of new thiosubstituted oxadiazole derivatives of coumarin under solvent-free conditionss

A series of new thiosubstituted 1,3,4-oxadiazole derivatives of coumarin were synthesised by reaction of 7-((5-mercapto-1,3,4-oxadiazol-2-yl)methoxy)-4-methyl-2H-chromen-2-one and α-haloketones by grinding, in solvent-free conditions at room temperature. The reaction was also carried out in ethanol in reflux conditions. Shorter reaction time and better yields were observed in solvent-free conditions. The structures of the compounds were characterised by IR, NMR, elemental analysis and mass spectral data. The synthesised compounds were evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi. Most of the compounds showed good to moderate activities.

An efficient one pot synthesis and antimicrobial activity of novel S-alkylisothiosemicarbazone and imidazolidinone derivatives of pyrazole carbaldehyde

S-Alkylisothiosemicarbazone and imidazolidinone derivatives were synthesised from pyrazole 4-carbaldehyde in a one pot reaction. The synthesised compounds were characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis. Most of the synthesised compounds showed antimicrobial activity against S. Aureus, B. subtilis, E. coli, P. aeruginos, A. Niger and C. albicans.