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Sadao Ishihara

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Publication

Featured researches published by Sadao Ishihara.

Bioorganic & Medicinal Chemistry Letters | 2003

Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties.

Sadao Ishihara; Fujio Saito; Yasuo Ohhata; Marie Kanai; Hiroshi Mizuno; Michio Fujisawa; Ryosuke Yorikane; Hiroyuki Koike

To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation.

The Journal of Antibiotics | 1987

STUDIES ON ORALLY ACTIVE CEPHALOSPORIN ESTERS

Koichi Fujimoto; Sadao Ishihara; Hiroaki Yanagisawa; Junya Ide; Ejji Nakayama; Hideo Nakao; Shinichi Sugawara; Masayuki Iwata

Journal of Medicinal Chemistry | 1987

Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives

Hiroaki Yanagisawa; Sadao Ishihara; Akiko Ando; Takuro Kanazaki; Shuichi Miyamoto; Hiroyuki Koike; Yasuteru Iijima; Kiyoshi Oizumi; Yoichi Matsushita; Tadashi Hata

Archive | 1996

Urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use

Akira Yoshida; Kozo Oda; Takashi Kasai; Kousei Shimada; Hiroshi Kogen; Ichiro Hayakawa; Sadao Ishihara; Teiichiro Koga; Eiichi Kitazawa; Taro Tokui

Journal of Medicinal Chemistry | 1988

Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives.

Hiroaki Yanagisawa; Sadao Ishihara; Akiko Ando; Takuro Kanazaki; Shuichi Miyamoto; Hiroyuki Koike; Yasuteru Iijima; Kiyoshi Oizumi; Yoichi Matsushita; Tadashi Hata

Archive | 1985

Perhydrothiazepine derivatives, their preparation and their therapeutic use

Hiroaki Yanagisawa; Sadao Ishihara; Akiko Ando; Takuro Kanazaki; Hiroyuki Koike; Yoshio Tsujita

Archive | 1994

Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses

Hiroshi Kogen; Sadao Ishihara; Teiichiro Koga; Eiichi Kitazawa; Nobufusa Serizawa; Kiyoshi Hamano

Archive | 1981

7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates

Hideo Nakao; Koichi Fujimoto; Sadao Ishihara; Shinichi Sugawara; Isamu Igarashi

Tetrahedron Letters | 1972

Studies on β-lactam antibiotics I. Skeletal conversion of cephalosporin to penicillin

Masafumi Yoshimoto; Sadao Ishihara; Eiji Nakayama; Nobuo Soma

Archive | 1981

Cephalosporin derivatives, their preparation and compositions containing them

Hideo Nakao; Koichi Fujimoto; Sadao Ishihara; Shinichi Sugawara; Isamu Igarashi

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Hiroyuki Koike

Osaka City University

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Fujio Saito

Tokyo Institute of Technology

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Hiroaki Yanagisawa

Daiichi Sankyo

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Hiroshi Kogen

Meiji Pharmaceutical University

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Akira Yoshida

University of Tokyo

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Koichi Fujimoto

Keio University

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Kozo Oda

Kyushu University

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Ryosuke Yorikane

University of Tsukuba

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Takao Yoshioka

Novartis

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Yoshio Tsujita

Kobe University

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