Sadiqa Firdous

PENTACYCLIC TRITERPENOIDS FROM LANTANA CAMARA

Abstract Seven pentacyclic triterpeonoids, camarinic acid, camaric acid, oleanolic acid, pomolic acid, lantanolic acid, lantanilic acid and lantic acid, have been isolated from the aerial parts of Lantana camara . The two new constituents, camarinic acid and camaric acid, have been characterized as 22β-acetoxy-3,25-epoxy-3α-hydroxy-12-ursen-28-oic acid and 3,25-epoxy-3 α -hydroxy-22 β (2-methyl-2 Z -butenoyloxy)-12-oleanen-28-oic acid, respectively. The structures of the new acids and lantanilic acid have been elucidated through extensive 1D and 2D NMR studies (COSY-45, NOESY, J -resolved, hetero-COSY), while those of the remainder rest on comparisons of their spectral data with the values reported in the literature.

Ophiamides A-B, new potent urease inhibitory sphingolipids from Heliotropium ophioglossum

Ophiamides A (1) and B (2), two new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and β-sitosterol 3-O-β-d-glucoside (4) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Both the compounds 1 and 2 showed potent inhibitory activity against the enzyme urease.

Two new diterpenoids from Salvia triloba

Two new diterpenoids, trilobic acid (1) and trilobiol (2), have been isolated from the methanolic extract of Salvia triloba. Their structures were elucidated with the aid of NMR spectroscopy including two-dimensional-NMR techniques.

A new triterpenoid from the leaves of Salvia triloba

The isolation and NMR spectral data of palestinol, a new triterpenoid from the leaves of Salvia triloba, are reported.

GC-MS profile of antimicrobial and antioxidant fractions from Cordia rothii roots.

Abstract Context: An ethnobotanical survey of Cordia rothii Roem. & Schult. (Boraginaceae) reveals it as a medicinal plant. Objective: Antimicrobial and antioxidant potential evaluation and identification of chemical constituents via GC-MS of C. rothii roots fractions. To the best of our knowledge, this is the first systematic investigation of the roots exploiting GC-MS. Materials and methods: Extraction and fractionation of C. rothii roots furnished various fractions using solvents of varying polarity, i.e., n-hexane, chloroform, ethyl acetate, acetone and methanol. In vitro antimicrobial and antioxidant screening was performed using disk diffusion and DPPH methods, respectively. MIC of active fractions was also determined using disk diffusion method. GC-MS was used to identify constituents which may be responsible for these activities. Results: Among various fractions from C. rothii roots, fraction KA-C showed strong antibacterial activity against 17 microorganisms tested, with MIC ranging from 250–31.25 μg/mL. Fractions KA-A, KM and KM-A exhibited significant antioxidant potential with EC50 46.875 μg/mL, while fractions KEA-PE, KM-PE and KM-M were good with EC50 93.750 μg/mL. Forty-five phytochemicals were identified in GC-MS studies including eight hydrocarbons, six free fatty acids, 11 fatty acids esters, two phenylpropanoids, four aromatics, four terpenoid quinones/hydroquinones, three triterpenes, four phytosterols, two hexose metabolites and a DNA base. Of these, 32 constituents have been reported for the first time from C. rothii, 24 from genus Cordia and 15 from Boraginaceae. Discussion and conclusion: Strong antibacterial and antioxidant potential of C. rothii roots may be due to the contribution of phytoconstituents identified through GC-MS studies.

Isolation and Structure Elucidation of Three Glycosides and a Long Chain Alcohol from Polianthes Tuberosa Linn

Three glycosides and a long chain alcohol were isolated from the bulbs of Polianthes tuberosa , these were identified as 3,29-dihydroxystigmast-5-ene-3- O - g - d -galactopyranoside ( 1 ) 1 , ethyl g - d -galactopyranoside ( 2 ), ethyl- f - d -galactopyranoside ( 3 ), and 1-tricosanol ( 4 ). The structures were determined by extensive spectroscopic and chemical methods. All four isolated compounds were screened for their cytotoxicity, antibacterial and antifungal activities, none of the compounds showed any significant activity.

A Novel Steroidal Saponin from Polianthes Tuberosa Linn.

Abstract From the bulbs of Polianthes tuberosa Linn., a novel steroidal saponin has been isolated. The molecular structure has been elucidated by extensive spectroscopic means and chemical reactions. The compounds has been identified as 2β,3β,16β,22β tetrahydroxycholesta-5-ene 16-O-β-D-apiofuranoside.