Salvatore Baldino
University of Sassari
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Salvatore Baldino.
Accounts of Chemical Research | 2015
Giorgio Chelucci; Salvatore Baldino; Walter Baratta
CONSPECTUS: A current issue in metal-catalyzed reactions is the search for highly efficient transition-metal complexes affording high productivity and selectivity in a variety of processes. Moreover, there is also a great interest in multitasking catalysts that are able to efficiently promote different organic transformations by careful switching of the reaction parameters, such as temperature, solvent, and cocatalyst. In this context, osmium complexes have shown the ability to catalyze efficiently different types of reactions involving hydrogen, proving at the same time high thermal stability and simple synthesis. In the catalytic reduction of C═X (X = O, N) bonds by both hydrogenation (HY) and transfer hydrogenation (TH) reactions, the most interest has been focused on homogeneous systems based on rhodium, iridium, and in particular ruthenium catalysts, which have proved to catalyze chemo- and stereoselective hydrogenations with remarkable efficiency. By contrast, osmium catalysts have received much less attention because they are considered less active on account of their slower ligand exchange kinetics. Thus, this area remained almost neglected until recent studies refuted these prejudices. The aim of this Account is to highlight the impressive developments achieved over the past few years by our and other groups on the design of new classes of osmium complexes and their applications in homogeneous catalytic reactions involving the hydrogenation of carbon-oxygen and carbon-nitrogen bonds by both HY and TH reactions as well as in alcohol deydrogenation (DHY) reactions. The work described in this Account demonstrates that osmium complexes are emerging as powerful catalysts for asymmetric and non-asymmetric syntheses, showing a remarkably high catalytic activity in HY and TH reactions of ketones, aldehydes, imines, and esters as well in DHY reactions of alcohols. Thus, for instance, the introduction of ligands with an NH function, possibly in combination with a pyridine ring, led to a new family of [OsCl2(PP)(NN)] (NN = diamine, 2-aminomethylpyridine; PP = diphosphine) and pincer [OsCl(CNN)(PP)] (HCNN = 6-aryl-2-aminomethylpyridine, 2-aminomethylbenzo[h]quinoline) complexes, which are outstanding catalysts for (asymmetric) HY and TH of carbonyl compounds and DHY of alcohols with turnover numbers and turnover frequencies up to 10(5) and 10(6) h(-1), respectively. In addition, PNN osmium complexes containing the 2-aminomethylpyridine motif have been found to be among the most active catalysts for HY of esters. These complexes have shown catalytic activities that are comparable and in some cases superior to those reported for analogous ruthenium systems. These results give an idea of the potential of Os complexes for the design of new highly productive and robust catalysts for the synthesis of chiral and nonchiral alcohols and amines as well as ketones from alcohols. Thus, we hope that this report will promote increased interest in the chemistry of these metal complexes, opening novel opportunities for new catalytic processes as well as the improvement of existing ones.
Journal of Organic Chemistry | 2012
Giorgio Chelucci; Salvatore Baldino; Andrea Ruiu
The pair NaBH(4)-TMEDA as a hydride source and catalytic PdCl(2)(dppf) in THF prove to be an efficient system for the hydrodehalogenation of bromo(chloro)-heteropentalenes with one or two heteroatoms, while Pd(OAc)(2)/PPh(3) is able to reduce reactive haloheteropentalenes, and PdCl(2)(tbpf) allows the removal of the 2-chlorine from a thiophene ring. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene, and nitrile substituents and also showing good efficiency in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates.
Chemistry: A European Journal | 2008
Walter Baratta; Maurizio Ballico; Salvatore Baldino; Giorgio Chelucci; Eberhardt Herdtweck; Katia Siega; Santo Magnolia; Pierluigi Rigo
Tetrahedron | 2008
Giorgio Chelucci; Salvatore Baldino; Gérard Aimé Pinna; Maurizio Benaglia; Laura Buffa; Stefania Guizzetti
Tetrahedron-asymmetry | 2006
Giorgio Chelucci; Salvatore Baldino; Simona Chessa; Gérard Aimé Pinna; Franco Soccolini
Tetrahedron | 2008
Giorgio Chelucci; Francesca Capitta; Salvatore Baldino
Tetrahedron | 2006
Giorgio Chelucci; Salvatore Baldino; Simona Chessa
Tetrahedron Letters | 2007
Giorgio Chelucci; Daniele Addis; Salvatore Baldino
Tetrahedron Letters | 2005
Giorgio Chelucci; Salvatore Baldino; Rosanna Solinas; Walter Baratta
Tetrahedron Letters | 2007
Giorgio Chelucci; Francesca Capitta; Salvatore Baldino; Gérard Aimé Pinna