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Samantha L. Shepherd

University of Huddersfield

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Publication

Featured researches published by Samantha L. Shepherd.

RSC Advances | 2018

Polymer encapsulation of anticancer silver–N-heterocyclic carbene complexes

Heba A. Mohamed; M. Khuphe; S. J. Boardman; Samantha L. Shepherd; Roger M. Phillips; P. D. Thornton; Charlotte E. Willans

Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. silver–N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

Journal of Medicinal Chemistry | 2015

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

Rianne M. Lord; Andrew J. Hebden; Christopher M. Pask; Imogen R. Henderson; Simon J. Allison; Samantha L. Shepherd; Roger M. Phillips; Patrick C. McGowan

Chemical Science | 2016

Anticancer metallohelices: nanomolar potency and high selectivity

Rebecca A. Kaner; Simon J. Allison; Alan D. Faulkner; Roger M. Phillips; David I. Roper; Samantha L. Shepherd; Daniel Simpson; Nicholas R. Waterfield; Peter Scott

Cancer Letters | 2017

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands

Simon J. Allison; Maria Sadiq; Efstathia Baronou; Patricia A. Cooper; Christopher Dunnill; Nikolaos T. Georgopoulos; Ayse Latif; Samantha L. Shepherd; Steve D. Shnyder; Ian J. Stratford; Richard T. Wheelhouse; Charlotte E. Willans; Roger M. Phillips

Polyhedron | 2016

Synthesis, structural, DFT calculations and biological studies of rhodium and iridium complexes containing azine Schiff-base ligands

Sanjay Adhikari; Dipankar Sutradhar; Samantha L. Shepherd; Roger M. Phillips; Asit K. Chandra; K. Mohan Rao

Journal of Organometallic Chemistry | 2016

Neutral and cationic half-sandwich arene ruthenium, Cp*Rh and Cp*Ir oximato and oxime complexes: Synthesis, structural, DFT and biological studies

Sanjay Adhikari; Narasinga Rao Palepu; Dipankar Sutradhar; Samantha L. Shepherd; Roger M. Phillips; Werner Kaminsky; Asit K. Chandra; Mohan Rao Kollipara

Applied Organometallic Chemistry | 2017

Half-sandwich ruthenium, rhodium and iridium complexes featuring oxime ligands: Structural studies and preliminary investigation of in vitro and in vivo anti-tumour activities

Narasinga Rao Palepu; Sanjay Adhikari; Richard Premkumar J; Akalesh Kumar Verma; Samantha L. Shepherd; Roger M. Phillips; Werner Kaminsky; Mohan Rao Kollipara

Cancer Letters | 2018

Corrigendum to “Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands” [Canc. Lett. 403 (2017) 98–107]

Simon J. Allison; Maria Sadiq; Efstathia Baronou; Patricia A. Cooper; Christopher Dunnill; Nikolaos T. Georgopoulos; Ayse Latif; Samantha L. Shepherd; Steve D. Shnyder; Ian J. Stratford; Richard T. Wheelhouse; Charlotte E. Willans; Roger M. Phillips

Angewandte Chemie | 2018

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Simon J. Allison; David J. Cooke; Francesca S. Davidson; Paul I. P. Elliott; Robert A. Faulkner; Hollie B. S. Griffiths; Owen J. Harper; Omar Hussain; P. Jane Owen-Lynch; Roger M. Phillips; Craig R. Rice; Samantha L. Shepherd; Richard T. Wheelhouse

Archive | 2015

Dataset to support article : 'Anticancer metallohelices : nanomolar potency and high selectivity'

Rebecca A. Kaner; Simon A. Allison; Alan D. Faulkner; Daniel Simpson; Nicholas R. Waterfield; Roger M. Phillips; David I. Roper; Samantha L. Shepherd; Peter Scott

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Collaboration

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Roger M. Phillips

University of Huddersfield

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Simon J. Allison

University of Huddersfield

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Alan D. Faulkner

University of Warwick

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Charlotte E. Willans

University of Leeds

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Daniel Simpson

University of Warwick

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David I. Roper

University of Warwick

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Nicholas R. Waterfield

University of Bath

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Peter Scott

University of Warwick

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Rebecca A. Kaner

University of Warwick

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Richard T. Wheelhouse

University of Bradford

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