Sang Lak Lee
Keimyung University
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Featured researches published by Sang Lak Lee.
Korean Journal of Pediatrics | 2017
Ji Eun Jeong; Jae Hyun Park; Chun Soo Kim; Sang Lak Lee; Hai Lee Chung; Woo Taek Kim; Eunjoo Lee
Purpose Hypoxic-ischemic encephalopathy is a significant cause of neonatal morbidity and mortality. Erythropoietin (EPO) is emerging as a therapeutic candidate for neuroprotection. Therefore, this study was designed to determine the neuroprotective role of recombinant human EPO (rHuEPO) and the possible mechanisms by which mitogen-activated protein kinase (MAPK) signaling pathway including extracellular signal-regulated kinase (ERK1/2), JNK, and p38 MAPK is modulated in cultured cortical neuronal cells and astrocytes. Methods Primary neuronal cells and astrocytes were prepared from cortices of ICR mouse embryos and divided into the normoxic, hypoxia (H), and hypoxia-pretreated with EPO (H+EPO) groups. The phosphorylation of MAPK pathway was quantified using western blot, and the apoptosis was assessed by caspase-3 measurement and terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Results All MAPK pathway signals were activated by hypoxia in the neuronal cells and astrocytes (P<0.05). In the neuronal cells, phosphorylation of ERK-1/-2 and apoptosis were significantly decreased in the H+EPO group at 15 hours after hypoxia (P<0.05). In the astrocytes, phosphorylation of ERK-1/-2, p38 MAPK, and apoptosis was reduced in the H+EPO group at 15 hours after hypoxia (P<0.05). Conclusion Pretreatment with rHuEPO exerts neuroprotective effects against hypoxic injury reducing apoptosis by caspase-dependent mechanisms. Pathologic, persistent ERK activation after hypoxic injury may be attenuateed by pretreatment with EPO supporting that EPO may regulate apoptosis by affecting ERK pathways.
Pediatric Gastroenterology, Hepatology & Nutrition | 2018
Hyo-Jeong Jang; Jae Hyun Park; Chun Soo Kim; Sang Lak Lee; Won Mok Lee
Purpose We investigated fecal calprotectin (FC) levels in preterm infants with and without feeding intolerance (FI), and compared the FC levels according to the type of feeding. Methods The medical records of 67 premature infants were reviewed retrospectively. The fully enteral-fed infants were classified into two groups; the FI group (29 infants) and the control group (31 infants). Seven infants with necrotizing enterocolitis, sepsis, and perinatal asphyxia were excluded. If breast milk (BM) or preterm formula (PF) could not be tolerated by infants with FI, amino acid-based formula (AAF) was tried temporarily. Once FI improved, AAF was discontinued, and BM or PF was resumed. We investigated the FC levels according to the type of feeding. Results Significant differences were found in gestational age, birth weight, age when full enteral feeding was achieved, and hospital stay between the FI and control group (p<0.05). The FC levels in the FI group were significantly higher than those in the control group (p<0.05). The FC levels in the AAF-fed infants with FI were significantly lower than those in the BM- or PF-fed infants (p<0.05). The growth velocities (g/d) and z scores were not significantly different between the FI and control group (p>0.05). Conclusion The FC levels in AAF-fed infants with FI showed significantly lower than those in the BM- or PF-fed infants with FI. The mitigation of gut inflammation through the decrease of FC levels in AAF-fed infants with FI could be presumed.
Korean Journal of Pediatrics | 2018
Se Jin Kim; Ga Eun Kim; Jae Hyun Park; Sang Lak Lee; Chun Soo Kim
Purpose In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients. Methods A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU. Results There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for EOS was group B Streptococcus (GBS), implicated in 10 cases (22.2%), followed by Escherichia coli, implicated in 9 cases (20%). The frequency of gram-positive sepsis was higher in term than in preterm infants, whereas the rate of gram-negative infection was higher in preterm than in term infants (P<0.05). The overall mortality was 37.8% (17 of 45), and 47% of deaths occurred within the first 3 days of infection. There were significant differences in terms of gestational age (26.8 weeks vs. 35.1 weeks) and birth weight (957 g vs. 2,520 g) between the death and survival groups. After adjustments based on the difference in gestational age and birth weight between the 2 groups, gram-negative pathogens (odds ratio [OR], 42; 95% confidence interval [CI], 1.4–1,281.8) and some clinical findings, such as neutropenia (OR, 46; 95% CI, 1.3–1,628.7) and decreased activity (OR, 34; 95% CI, 1.8–633.4), were found to be associated with fatality. Conclusion The common pathogens found to be responsible for EOS in NICU patients are GBS and E. coli. Gram-negative bacterial infections, decreased activity in the early phase of infection, and neutropenia were associated with poor outcomes.
Korean Journal of Pediatrics | 2007
Su Min Shon; Bo Young Lee; Chun Soo Kim; Sang Lak Lee; Tae Chan Kwon
Korean Journal of Perinatology | 2010
Chun Soo Kim; Seung Ah Hong; Sang Lak Lee; Heung Sik Kim
Korean Journal of Pediatrics | 2008
In Kug Bang; Yeo Hyang Kim; Chun Soo Kim; Sang Lak Lee; Tae Chan Kwon
Korean Journal of Pediatrics | 2004
Soo Jung Yoon; Chun Soo Kim; Sang Lak Lee
Korean Journal of Pediatrics | 2003
Jong Uk Lee; Won Joung Choi; Chun Soo Kim; Sang Lak Lee; Jun Sik Kim
Korean Journal of Pediatrics | 2001
Sung Jun Jang; Yoon Jung Cho; Sang Lak Lee; Joon Sik Kim; Tae Chan Kwon
Korean Journal of Pediatrics | 1998
Tae Chan Kwon; Joon Sik Kim; Sang Lak Lee; Myung Sung Kim; Geun Soo Park; Chun Soo Kim; In Joo Kim; Bin Ahn