Sang Soo Cho

Subcortical Vascular versus Amnestic Mild Cognitive Impairment: Comparison of Cerebral Glucose Metabolism

Most studies on mild cognitive impairment (MCI) have been focused on amnestic MCI (aMCI) that is the preclinical stage of Alzheimers disease (AD). In contrast, only a few studies have involved patients in the preclinical stages of subcortical vascular dementia (subcortical vascular MCI, svMCI). We tried to compare the overall glucose metabolism in patients with svMCI with that of patients with aMCI.

Pattern of glucose hypometabolism in frontotemporal dementia with motor neuron disease

Frontotemporal dementia (FTD) often coexists with motor neuron disease (MND). To characterize glucose hypometabolism in patients with FTD with MND (FTD/MND), the authors compared the glucose metabolism of 8 patients with FTD/MND with that of 29 patients with FTD. All of the patients with FTD/MND showed glucose hypometabolism only in the frontal area, whereas most patients with FTD had hypometabolism in the frontal and temporal areas. FTD/MND also showed a more symmetric pattern of glucose hypometabolism than FTD.

Glucose metabolism in sporadic Creutzfeldt-Jakob disease: a statistical parametric mapping analysis of (18) F-FDG PET.

Background and purpose:  Reports describing functional neuroimaging techniques, such as positron emission tomography (PET) and single‐photon emission computed tomography (SPECT), in sporadic Creutzfeldt–Jakob disease (sCJD) have consistently suggested that these tools are sensitive for the identification of areas of hypoperfusion or hypometabolism, even in the early stages of sCJD. However, there are few reports on the use of [18F]fluoro‐2‐deoxy‐D‐glucose (FDG) PET in sCJD, and most of them are single case reports. Only two small cohort studies based on visual inspection or a region of interest method have been published to date. Using a statistical parametric mapping (SPM) analysis of 18F‐FDG PET, we investigated whether there are brain regions preferentially affected in sCJD.

Effect of illiteracy on neuropsychological tests and glucose metabolism of brain in later life.

The acquisition of literacy during childhood may affect the functional organization of the brain. We studied the effects of illiteracy on neuropsychological tests and brain glucose metabolism in later life.

Neural correlates of hemispatial neglect: a voxel-based SPECT study.

Background: Despite many studies that investigated the neural correlates of hemispatial neglect (HN) with structural imaging, studies using voxel-wise analyses of functional imaging are not available. Furthermore, previous studies neither considered the neglect severity nor investigated whether there are differences in these neural correlates according to each neglect subtest. This study aimed to investigate the neural correlates of HN by correlating the total and the individual neglect score with hypoperfusion value on single photon emission computed tomography (SPECT) using voxel-wise analyses. Methods: Forty-two patients with acute right hemisphere strokes underwent a neglect test battery consisting of 3 bisection tasks, 2 cancellation tasks and 2 copying tasks. The SPECT images were acquired in these patients and 10 age- and education-matched normal controls. Results: Patients with HN, compared to those without HN, had hypoperfusion in the right middle temporal-occipital junction, inferior frontal gyrus and retrosplenial area. The total neglect score correlated with the hypoperfusion in the right middle temporal-occipital junction, fusiform gyrus, parahippocampal gyrus, inferior temporal gyrus, anterior part of the superior and middle temporal gyri, cuneus, lingual gyrus, angular gyrus, and the cerebellum. Across the neglect subtests similar correlation patterns were observed with minor variations. Conclusions: Unlike the results of previous studies showing that the critical neural correlates for HN are inferior parietal lobule or superior temporal gyrus, our study showed that the lesions that critically contribute to the neglect severity were located in the posterior parts of the middle temporal gyrus (temporal-occipital junction).

Multicenter subcortical vascular dementia on FDG-PET (VADAPET) study signifies more posterior network hypometabolism

M arcio Balthazar, Benito Damasceno, Cassio Bottino, Sonia Brucki, Ricardo Nitrini, University of S~ao Paulo, S~ao Paulo, Brazil; School of Medicine of the University of S~ao Paulo, S~ao Paulo, Brazil; School of Medicine of the University of S~ao Paulo, S~ao Paulo, Brazil; Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil; Federal University of Minas Gerais, Belo Horizonte – Minas Gerais, Brazil; Federal University of Minas Gerais, Beo Horizonte-MG, Brazil; State University of Campinas, Campinas, Brazil; Unicamp, Campinas, Brazil; University of S~ao Paulo, S~ao Paulo, Brazil; HCFMUSP Hospital Santa Marcelina, S~ao Paulo, Brazil. Contact e-mail: yassuda@usp.br

Glucose metabolism in sporadic Creutzfeldt-Jakob disease: a statistical parametric mapping analysis of 18F-FDG PET: PET in sporadic CJD

Background and purpose:  Reports describing functional neuroimaging techniques, such as positron emission tomography (PET) and single‐photon emission computed tomography (SPECT), in sporadic Creutzfeldt–Jakob disease (sCJD) have consistently suggested that these tools are sensitive for the identification of areas of hypoperfusion or hypometabolism, even in the early stages of sCJD. However, there are few reports on the use of [18F]fluoro‐2‐deoxy‐D‐glucose (FDG) PET in sCJD, and most of them are single case reports. Only two small cohort studies based on visual inspection or a region of interest method have been published to date. Using a statistical parametric mapping (SPM) analysis of 18F‐FDG PET, we investigated whether there are brain regions preferentially affected in sCJD.