Sarah Muirhead-Allwood

Circulating levels of cobalt and chromium from metal-on-metal hip replacement are associated with CD8+ T-cell lymphopenia

We carried out a cross-sectional study with analysis of the demographic, clinical and laboratory characteristics of patients with metal-on-metal hip resurfacing, ceramic-on-ceramic and metal-on-polyethylene hip replacements. Our aim was to evaluate the relationship between metal-on-metal replacements, the levels of cobalt and chromium ions in whole blood and the absolute numbers of circulating lymphocytes. We recruited 164 patients (101 men and 63 women) with hip replacements, 106 with metal-on-metal hips and 58 with non-metal-on-metal hips, aged < 65 years, with a pre-operative diagnosis of osteoarthritis and no pre-existing immunological disorders. Laboratory-defined T-cell lymphopenia was present in 13 patients (15%) (CD8(+) lymphopenia) and 11 patients (13%) (CD3(+) lymphopenia) with unilateral metal-on-metal hips. There were significant differences in the absolute CD8(+) lymphocyte subset counts for the metal-on-metal groups compared with each control group (p-values ranging between 0.024 and 0.046). Statistical modelling with analysis of covariance using age, gender, type of hip replacement, smoking and circulating metal ion levels, showed that circulating levels of metal ions, especially cobalt, explained the variation in absolute lymphocyte counts for almost all lymphocyte subsets.

Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topography

Widespread concern exists about adverse tissue reactions after metal‐on‐metal (MoM) total hip replacement (THR). Concerns have also been expressed with wear and corrosion of taper junctions in THR. We report the effect of surface finish and contact area associated with a single combination of materials of modular tapers. In an in vitro test, we investigated the head/neck (CoCrMo/Ti) interface of modular THRs using commercially available heads. Wear and corrosion of taper surfaces was compared following a 10 million loading cycle. Surface parameters and profiles were measured before and after testing. Electrochemical static and dynamic corrosion tests were performed under loaded and non‐loaded conditions. After the load test, the surface roughness parameters on the head taper were significantly increased where the head/neck contact area was reduced. Similarly, the surface roughness parameters on the head taper were significantly increased where rough neck tapers were used. Corrosion testing showed breaching of the passive film on the rough but not the smooth neck tapers. Thus, surface area and surface finish are important factors in wear and corrosion at modular interfaces.

The effect of a lateral flare feature on uncemented hip stems

Ideal goals for a primary uncemented femoral stem prosthesis are to transmit the loads to the femur proximally, and to minimise the interface migration. It has been proposed that the addition of a lateral flare which loads the lower region of the greater trochanter will contribute positively to these goals. Analytical and radiographic studies were used to study the load transfer between the stem and the bone, and the migration. A comparison was made between a straight stem, and a straight stem with the addition of a lateral flare. The finite element study showed that the straight stem migrated down the canal approximately four millimeters before stabilisation was reached. The forces were transmitted on to the proximal-medial femur and around the lower half of the stem. When the lateral flare was added, there was only one millimeter of migration to reach stability. The loads were transferred by a wedging effect between the proximal-medial femur and the around the lateral flare, with little force transfer from the stem. In a radiographic follow-up of an HA-coated lateral flare stem, trabeculae could be seen attaching to the lateral flare. The axial migration was significantly less for this stem design compared with that from a series of previously reported cemented stems. This study suggested that the lateral flare contributed positively to the goals of uncemented stem design, and that the stems could be made shorter than designs not incorporating the lateral flare feature.

Which Factors Determine the Wear Rate of Large-Diameter Metal-on-Metal Hip Replacements? Multivariate Analysis of Two Hundred and Seventy-six Components

BACKGROUND Determining the relationship between clinical factors and engineering analysis of retrieved hip implants can help our understanding of the mechanism of device failure. This is particularly important for metal-on-metal hip arthroplasties because the most common cause of failure is unexplained. We sought to understand the variation in wear rates in a large series of retrieved metal-on-metal hip arthroplasty components. METHODS We prospectively recorded preoperative, intraoperative, and postoperative data to study the effect on both head and cup wear rates of the following variables: patient sex, cause of failure, manufacturer type, resurfacing or modular design, blood cobalt and chromium levels, edge-loading, femoral head size, and cup inclination angle. We analyzed 276 components (138 femoral head and acetabular cup couples) retrieved from failed metal-on-metal hip replacements. RESULTS We found a high rate of edge-loading (64%), but only forty-three (31%) of 138 hips had a cup inclination angle of >55°. Multivariate analysis showed that the most important factor responsible for the variation in wear rate was the presence or absence of edge-loading, even when adjusted for cup inclination angle. Strong positive correlations were found between acetabular cup and femoral head wear rates and between wear rates and both blood cobalt and chromium ion levels. CONCLUSIONS Multivariate analysis of nine factors found that edge-loading was the most important predictor of wear rate and occurred in two-thirds of failed metal-on-metal hip replacements. The majority did not have excessive cup inclination angles: 68% had an inclination angle of ≤55°. This finding, together with the relatively low median wear rate of the components in our study, suggests that cup position and/or wear rate may not be the only outcome related to failure of metal-on-metal hip replacements.

LESSONS OF A HIP FAILURE

News p 650 The hazard warning issued this month by the Medical Devices Agency in Britain on the 3M Capital hip system evoked emotion but no surprise among hip surgeons.1 Previous reports of failures have suggested the need for better surveillance,2 and five years ago a BMJ editorial warned, presciently, “This ‘fashion trade’ in joint replacements is costing the health service many millions of pounds each year and, even more important, is causing patients unnecessary pain and distress through early failure of unproved implants.”3 The 3M Capital hip was introduced in 1991 as a low cost hip replacement. Adverse reviews have already been reported, and its failure rates of 19-21% at five years1 are four times what would normally be expected and suggest an intrinsic problem. Yet over six years 4669 have been implanted in 95 centres throughout Britain. For a new and untested hip to have ben introduced into so many clinical centres in such a short …

UNCEMENTED TOTAL HIP ARTHROPLASTY WITH SUBTROCHANTERIC DEROTATIONAL OSTEOTOMY FOR SEVERE FEMORAL ANTEVERSION

Total hip joint arthroplasty (THA) in the presence of severe femoral anteversion (>50 degrees) is technically demanding. This problem is often encountered in patients with osteoarthritis secondary to hip joint dysplasia or congenital dislocation. We describe a method of THA in which an uncemented femoral prosthesis is used in conjunction with subtrochanteric derotational osteotomy. This technique allows the restoration of the normal proximal femoral anatomy, including the abductor muscle lever arm without resorting to greater trochanteric transfer. Correction of the excessive femoral anteversion avoids the tendency for postoperative anterior instability. The osteotomy site may also serve as the site for femoral shortening or angular correction when required, which preserves the normal femoral flare. The prostheses used were custom CAD/CAM (computer-assisted design/computer-assisted manufacturer) in design and had the following features: a close intramedullary proximal fit, with collar, lateral flare, and hydroxyapatite coating to achieve early proximal fixation, and longitudinally cutting fluted stem to provide immediate rotational stability across the osteotomy site. Although we used CAD/CAM custom prostheses, off-the-shelf uncemented hip prostheses with similar design features have become available. We report on 7 patients who underwent THA using this technique. The average patient age was 49 years (range, 34-61 years) with a mean follow-up period of 31 months (range, 16-60 months). To date, all cases have had a satisfactory outcome with evidence of union at the osteotomy site. Harris hip scores improved from an average of 44 preoperatively to 91 by the end of follow-up period. One case was complicated by delayed union at the osteotomy site, which was successfully corrected with bone grafting and temporary plate stabilization.

Stability and bone preservation in custom designed revision hip stems.

Three types of uncemented femoral stems were designed for patients having revision hip surgery, with the goals of promoting axial stability and preserving proximal bone stock. These stems were made individually using computer design and manufacturing technology. Various design features were examined using nonlinear finite element analysis. All stems had lateral, medial, and anterior flares in the proximal region, proximal hydroxyapatite coating, and a collar. Based on a published classification system, the three designs were found suitable for variously encountered cavitary defects. For cases involving small amounts of bone destruction, a primary type of stem was used. With severe cases, an extended polished stem was used. For the worst cases, an extended stem with longitudinal cutting flutes and complete hydroxyapatite coating was necessary. The axial migration was measured radiographically for a 2-year period. The migration rates were comparable with those seen in cemented primary and in custom primary hydroxyapatite coated stems. Dual energy xray absorptiometry data were obtained during a 4-year postoperative period. Average bone density in all regions was maintained within 12% of the immediate postoperative values. It was concluded that the proposed system for treating patients needing revision hip surgery showed desirable properties that were comparable to primary hip replacements.

Acetabular Reconstruction With Morcellized Allograft and Ring Support A Medium-Term Review

Acetabular bone stock deficiency is commonly encountered in revision hip surgery. A number of techniques are available to address this problem, including the use of particulate allograft with reconstruction rings in an effort to provide a stable construct and replenish bone stock. Our technique and results using such devices in complex acetabular deficiencies are described. In the setting of a large nmedial segmental or cavitary acetabular defect, morcellized bone-graft is used to reconstitute the acetabular floor. This graft is reverse reamed until its depth allows screw fixation of a metallic support ring. The screws also serve to compress the graft. A polyethylene acetabular component is then cemented into the reconstituted acetabulum with full freedom of orientation. A series of 48 patients in whom this technique was employed is presented. These cases have been clinically and radiologically reviewed with a mean follow-up of 64 months (range, 25-102 months). Good bony incorporation with stable acetabular components was seen in all but the two cases in which sepsis predominated.

Uncemented custom computer-assisted design and manufacture of hydroxyapatite-coated femoral components: SURVIVAL AT 10 TO 17 YEARS

We present the 10- to 17-year results of 112 computer-assisted design computer-assisted manufacture femoral components. The total hip replacements were performed between 1992 and 1998 in 111 patients, comprising 53 men and 58 women. Their mean age was 46.2 years (24.6 to 62.2) with a mean follow-up of 13 years (10 to 17). The mean Harris Hip Score improved from 42.4 (7 to 99) to 90.3 (38 to 100), the mean Oxford Hip Score from 43.1 (12 to 59) to 18.2 (12 to 51) and the mean Western Ontario MacMasters University Osteoarthritis Index score from 57.0 (7 to 96) to 11.9 (0 to 85). There was one revision due to failure of the acetabular component but no failures of the femoral component. There were no revisions for aseptic loosening. The worst-case survival in this cohort of custom femoral components at 13.2 years follow-up was 98.2% (95% confidence interval 95 to 99). Overall survival of this series of total hip replacements was 97.3% (95% confidence interval 95 to 99). These results are comparable with the best medium- to long-term results for femoral components used in primary total hip replacement with any means of fixation.

Revision of failed hip resurfacing to total hip arthroplasty rapidly relieves pain and improves function in the early post operative period

We reviewed the results of 25 consecutive patients who underwent revision of a hip resurfacing prosthesis to a total hip replacement. Revisions were performed for recurrent pain and effusion, infection and proximal femoral fractures. Both components were revised in 20 cases.There were 12 male and 13 female patients with average time to revision of 34.4 and 26.4 months respectively. The mean follow up period was 12.7 months (3 to 31). All patients reported relief of pain and excellent satisfaction scores. Two patients experienced stiffness up to three months post operatively.Pre operative Oxford, Harris and WOMAC hip scores were 39.1, 36.4 and 52.2 respectively. Mean post operative scores at last follow up were 17.4, 89.8 and 6.1 respectively (p < 0.001 for each score). These results show that conversion of hip resurfacing to total hip arthroplasty has high satisfaction rates. These results compare favourably with those for revision total hip arthroplasty.