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Dive into the research topics where John Skinner is active.

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Featured researches published by John Skinner.


Journal of Arthroplasty | 2011

Magnetic Resonance Imaging Findings in Painful Metal-On-Metal Hips A Prospective Study

Shiraz Sabah; Adam Mitchell; Johann Henckel; Ann Sandison; John Skinner; A. J. Hart

Metal artifact reduction sequence magnetic resonance imaging findings are reported in a prospective series of 31 patients with unexplained painful metal-on-metal (MOM) hips. The abnormalities identified were fluid collection (20 patients), solid mass (2 patients), moderate to severe muscle atrophy (23 patients), and muscle edema (8 patients). In conclusion, soft tissue lesions and muscle atrophy appear to be prevalent in unexplained painful MOM hips. Metal artifact reduction sequence magnetic resonance imaging may be useful to diagnose and monitor at-risk hips but requires validation in well-functioning MOM hips before it can guide clinical decision making.


Acta Orthopaedica | 2014

A comparison of the diagnostic accuracy of MARS MRI and ultrasound of the painful metal-on-metal hip arthroplasty.

Imran A Siddiqui; Shiraz Sabah; Keshthra Satchithananda; Adrian Lim; Suzie Cro; Johann Henckel; John Skinner; Alister Hart

Background and purpose — Metal artifact reduction sequence (MARS) MRI and ultrasound scanning (USS) can both be used to detect pseudotumors, abductor muscle atrophy, and tendinous pathology in patients with painful metal-on-metal (MOM) hip arthroplasty. We wanted to determine the diagnostic test characteristics of USS using MARS MRI as a reference for detection of pseudotumors and muscle atrophy. Patients and methods — We performed a prospective cohort study to compare MARS MRI and USS findings in 19 consecutive patients with unilateral MOM hips. Protocolized USS was performed by consultant musculoskeletal radiologists who were blinded regarding clinical details. Reports were independently compared with MARS MRI, the imaging gold standard, to calculate predictive values. Results — The prevalence of pseudotumors on MARS MRI was 68% (95% CI: 43–87) and on USS it was 53% (CI: 29–76). The sensitivity of USS in detecting pseudotumors was 69% (CI 39–91) and the specificity was 83% (CI: 36–97). The sensitivity of detection of abductor muscle atrophy was 47% (CI: 24–71). In addition, joint effusion was detected in 10 cases by USS and none were seen by MARS MRI. Interpretation — We found a poor agreement between USS and MARS MRI. USS was inferior to MARS MRI for detection of pseudotumors and muscle atrophy, but it was superior for detection of joint effusion and tendinous pathologies. MARS MRI is more advantageous than USS for practical reasons, including preoperative planning and longitudinal comparison.


Chemical Communications | 2012

Chemical speciation of nanoparticles surrounding metal-on-metal hips

Angela E. Goode; James M. Perkins; Ann Sandison; Chithra Karunakaran; Huikai Cheng; D Wall; John Skinner; A. J. Hart; Alexandra E. Porter; David W. McComb; Mary P. Ryan

Spectromicroscopy of tissue surrounding failed CoCr metal-on-metal hip replacements detected corroded nanoscale debris in periprosthetic tissue in two chemical states, with concomitant mitochondrial damage. The majority of debris contained Cr(3+), with trace amounts of oxidised cobalt. A minority phase containing a core of metallic chromium and cobalt was also observed.


Journal of Tissue Engineering and Regenerative Medicine | 2008

Matrix stiffness and serum concentration effects matrix remodelling and ECM regulatory genes of human bone marrow stem cells

D. Karamichos; John Skinner; R.A. Brown; Vivek Mudera

The effects of mechanical stimulation of cell‐seeded collagen constructs on cell orientation, intracellular signalling and molecular responses have been widely reported. In this study we investigated in vitro the contractile responses of human bone marrow stem cells (HBMSCs) to increasing collagen gel substrate stiffness and their effect on extracellular matrix (ECM) regulatory genes. Human dermal fibroblasts (HDFs) were used as controls. Cells were cultured in 10% and 20% FCS and embedded in collagen constructs at a density of 1 million cells/ml collagen. Matrix stiffness was achieved by subjecting the constructs to three different strain regimes (0%, 5% and 10%), using a computer‐driven tensional culture force monitor (t‐CFM) capable of uniaxial loading. The contraction forces generated by the cells were quantified over 24 h. Molecular outputs were quantified using RT–PCR. HBMSCs significantly increased force generation to increasing serum concentration (i.e 10% to 20%). 10% FCS concentration significantly reduced contraction as pre‐strain stiffness was increased in HBMSCs and HDFs (0% > 5% > 10%). However, at 20% FCS HBMSCs generated similar peak force contraction at 24 h to 5% and 10% pre‐strain (0% = 5% = 10%). The ECM regulatory gene for MMP2 showed upregulation at 5% pre‐strain, but a 50% downregulation when pre‐strain was increased to 10%. MMP9 was upregulated at 5% pre‐strain and further upregulated at 10% pre‐strain. In designing tissue‐engineering solutions, predictable responses of cells, embedded within bio‐artificial matrices, to external mechanical forces are critical. To take into account the increasing stiffness of the matrix as increasing ECM is deposited, it would be necessary to take mechanical stimulation into account to determine predictable cellular responses. Copyright


Journal of Bone and Joint Surgery-british Volume | 2016

The effect of using components from different manufacturers on the rate of wear and corrosion of the head–stem taper junction of metal-on-metal hip arthroplasties

Robert K. Whittaker; Harry Hothi; Jay Meswania; R. Berber; Gordon W. Blunn; John Skinner; Alister Hart

AIMS Surgeons have commonly used modular femoral heads and stems from different manufacturers, although this is not recommended by orthopaedic companies due to the different manufacturing processes. We compared the rate of corrosion and rate of wear at the trunnion/head taper junction in two groups of retrieved hips; those with mixed manufacturers (MM) and those from the same manufacturer (SM). MATERIALS AND METHODS We identified 151 retrieved hips with large-diameter cobalt-chromium heads; 51 of two designs that had been paired with stems from different manufacturers (MM) and 100 of seven designs paired with stems from the same manufacturer (SM). We determined the severity of corrosion with the Goldberg corrosion score and the volume of material loss at the head/stem junction. We used multivariable statistical analysis to determine if there was a significant difference between the two groups. RESULTS We found no significant difference in the corrosion scores of the two groups. The median rate of material loss at the head/stem junction for the MM and SM groups were 0.39 mm(3)/year (0.00 to 4.73) and 0.46 mm(3)/year (0.00 to 6.71) respectively; this difference was not significant after controlling for confounding factors (p = 0.06). CONCLUSION The use of stems with heads of another manufacturer does not appear to affect the amount of metal lost from the surfaces between these two components at total hip arthroplasty. Other surgical, implant and patient factors should be considered when determining the mechanisms of failure of large diameter metal-on-metal hip arthroplasties. Cite this article: Bone Joint J 2016;98-B:917-24.


European Spine Journal | 2017

Analysing a mechanism of failure in retrieved magnetically controlled spinal rods

Vasiliki Panagiotopoulou; Stewart Tucker; Robert K. Whittaker; Harry Hothi; Johann Henckel; Julian J. H. Leong; Thomas Ember; John Skinner; Alister Hart

PurposeWe aim to describe a mechanism of failure in magnetically controlled growth rods which are used for the correction of the early onset scoliosis.MethodsThis retrieval study involved nine magnetically controlled growth rods, of a single design, revised from five patients for metal staining, progression of scoliosis, swelling, fractured actuator pin, and final fusion. All the retrieved rods were radiographed and assessed macroscopically and microscopically for material loss. Two implants were further analysed using micro-CT scanning and then sectioned to allow examination of the internal mechanism. No funding was obtained to analyse these implants. There were no potential conflicts interests.ResultsPlain radiographs revealed that three out of nine retrieved rods had a fractured pin. All had evidence of surface degradation on the extendable telescopic rod. There was considerable corrosion along the internal mechanism.ConclusionsWe found that a third of the retrieved magnetically controlled growth rods had failed due to pin fracture secondary to corrosion of the internal mechanism. We recommend that surgeons consider that any inability of magnetically controlled growth rods to distract may be due to corrosive debris building up inside the mechanism, thereby preventing normal function.


Journal of Bone and Joint Surgery-british Volume | 2017

ASSESSMENT OF THE EQUIVALENCE OF A GENERIC TO A BRANDED FEMORAL STEM

Harry Hothi; Johann Henckel; Paul R. Shearing; T. Holme; Arianna Cerquiglini; A. Di Laura; A. Atrey; John Skinner; Alister Hart

Aims The aim of this study was to compare the design of the generic OptiStem XTR femoral stem with the established Exeter femoral stem. Materials and Methods We obtained five boxed, as manufactured, implants of both designs at random (ten in total). Two examiners were blinded to the implant design and independently measured the mass, volume, trunnion surface topography, trunnion roughness, trunnion cone angle, Caput‐Collum‐Diaphyseal (CCD) angle, femoral offset, stem length, neck length, and the width and roughness of the polished stem shaft using peer‐reviewed methods. We then compared the stems using these parameters. Results We found that the OptiStems were lighter (p < 0.001), had a rougher trunnion surface (p < 0.001) with a greater spacing and depth of the machined threads (p < 0.001), had greater trunnion cone angles (p = 0.007), and a smaller radius at the top of the trunnion (p = 0.007). There was no difference in stem volume (p = 0.643), CCD angle (p = 0.788), offset (p = 0.993), neck length (p = 0.344), stem length (p = 0.808), shaft width (p = 0.058 to 0.720) or roughness of the polished surface (p = 0.536). Conclusion This preliminary investigation found that whilst there were similarities between the two designs, the generic OptiStem is different to the branded Exeter design.


Journal of Orthopaedic Research | 2016

Calculating the hip center of rotation using contralateral pelvic anatomy

Matthieu Durand-Hill; Johann Henckel; Keshthra Satchithananda; Shiraz Sabah; Jia Hua; Harry Hothi; Ronald J. Langstaff; John Skinner; Alister Hart

Failure to place an artificial hip in the optimal center of rotation results in poor hip function and costly complications. The aim of this study was to develop robust methodology to estimate hip center of rotation (hCoR) from preoperative computed tomography (CT) scans, using contralateral anatomy, in patients with unilateral diseased hips. Ten patients (five male, five female) with normal pelvic anatomy, and one patient with a unilateral dysplastic acetabulum were recruited from the London Implant Retrieval center image bank. 3D models of each pelvis were generated using commercial software. Two methods for estimation of hCoR were compared. Method 1 used a mirroring technique alone. Method 2 utilized mirroring and automatic alignment. Predicted versus actual hCoR co‐ordinates were compared using intraclass correlation coefficients and paired T‐tests. Both methods predicted hCoR with excellent agreement to original co‐ordinates (>0.9) in all axes. Both techniques allowed prediction of the hCoR within ± 5 mm in all axes. Both techniques provided useful clinical information for planning acetabular reconstruction in patients with unilateral defects. Method 1 was less complex and is suitable for patients with developmental and degenerative pathologies. Method 2 may provide greater accuracy in a discrete group of patients with normal development prior to pathology (e.g., acetabular fractures).


Journal of Biomedical Materials Research Part B | 2018

Assessment of corrosion in retrieved spine implants

Vasiliki Panagiotopoulou; Harry Hothi; H. A. Anwar; S. Molloy; H. Noordeen; K. Rezajooi; J. Sutcliffe; John Skinner; Alister Hart

Recently the use of dissimilar metals in spine instrumentation has increased, especially in the case of adult deformities, where rods made from Cobalt Chrome alloys (CoCr) are used with Titanium (Ti) screws. The use of dissimilar metals increases the risk of galvanic corrosion and patients have required revision spine surgery due to severe metallosis that may have been caused by corrosion. We aimed to assess the presence of corrosion in spine implant retrievals from constructs with two types of material combinations: similar (Ti/Ti) and dissimilar (CoCr/Ti). First, we devised a grading score for corrosion of the rod-fixture junctions. Then, we applied this score to a collection of retrieved spine implants. Our proposed corrosion grading score was proven reliable (kappa > 0.7). We found no significant difference in the scores between 4 CoCr and 11 Ti rods (p = 0.0642). There was no indication that time of implantation had an effect on the corrosion score (p = 0.9361). We recommend surgeons avoid using implants designs with dissimilar metals to reduce the risk of corrosion whilst a larger scale study of retrieved spine implants is conducted. Future studies can now use our scoring system for spine implant corrosion.


Skeletal Radiology | 2017

Detection of incorrect manufacturer labelling of hip components

Matthieu Durand-Hill; Johann Henckel; Matthew Burwell; John Skinner; Alister Hart

We describe the case of a 53-year-old man who underwent a left metal-on-metal hip resurfacing in 2015. Component size mismatch (CSM) was suspected because of the patient’s immediate post-operative mechanical symptoms and high metal ion levels. Surgical notes indicated the appropriate combinations of implants were used. However, we detected a mismatch using computed tomography. Revision was performed and subsequent measurements of explanted components confirmed the mismatch. To our knowledge, this case is the first report of a CT method being used in a patient to pre-operatively identify CSM.

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Alister Hart

University of Huddersfield

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Harry Hothi

Royal National Orthopaedic Hospital

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Johann Henckel

Royal National Orthopaedic Hospital

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Shiraz Sabah

Imperial College London

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A. J. Hart

Charing Cross Hospital

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George Bentley

University College London

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Paul J. Bills

University of Huddersfield

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Richard Carrington

Royal National Orthopaedic Hospital

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