Sarinder Man Singh

Rheumatoid factor: correlation with recurrence in transitional cell carcinoma of the bladder.

The serum rheumatoid factor was measured by the latex fixation test in different titrations in 100 cases of bladder tumors. The rheumatoid factor was found in transitional and squamous cell carcinoma of the bladder. The percentage of positive studies correlated well with the clinical staging of the tumors. The rheumatoid factor activity also correlated with the recurrence of transitional cell carcinoma. A high recurrence rate was found when the rheumatoid factor was present in contrast to a low recurrence rate when it was absent at the initial examination. The percentage of recurrences correlated with the titration of the rheumatoid factor. The mechanism of production of the rheumatoid factor and its correlation with tumor recurrence are discussed.

Extra-adrenal Pheochromocytoma Producing Renal Artery Stenosis

A case of extra-adrenal pheochromocytoma on the left side in relation to the left renal pedicle, producing renal artery stenosis, is described because of its rarity, and diagnostic and therapeutic problems. The pheochromocytoma was excised and the kidney was preserved.

Rheumatoid Factor in Bladder Tumors

We used the standard latex fixation test to screen 71 patients with bladder tumors and appropriate controls for the rheumatoid factor. The rheumatoid factor was present in transitional and squamous cell carcinoma of the bladder. Positivity was correlated with staging and histological grading of the tumor. In control subjects it was present in squamous cell carcinoma of the penis and anal canal. The possibility of the circulating immune complex with tumor antigen and its antibody has been discussed.

Complications and Management of “Neglected” Renal Stones

In developed countries, with better facilities for medical and surgical treatment of urolithiasis, calculi usually are not “neglected” although even from affluent countries, there are reports of patients in whom surgery was advised, but they have failed to take advantage of it. This study of 50 patients with renal/ureteric stone “neglected” by the patients so far as orthodox treatment is concerned have been collected from the records of patients admitted to the Institute Hospital during the period from January 1, 1979, to March 31, 1980. The reason for neglect has been most often patient fear of and unwillingness to undergo surgery, but to nearly an equal extent it has been due to claims by practitioners of “folk lore” medicine or rival system of medicine that they had some medicine to dissolve the stone. Ninety percent of the stones have contained calcium and 10% contained uric acid. There have been no cystine stones in this group.