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Archive | 1993

Effect and Action Mechanism of Prostaglandin E2 on Proliferation of Human Colon Cancer Cells in Culture

Michio Kato; Satoru Okumoto; Yoichi Saitoh; Yuichi Hori; Daisuke Kuroda; Hideaki Nomura; Shinichi Nishimatsu; Harumasa Ohyanagi

The effect of prostaglandin E2(PGE2) on the growth of human colon cancer cell line HT-29 was investigated. PGE2 significantly inhibited the growth of HT-29 cells without increasing cyclicAMP production. Furthermore, the proliferation of HT-29 cell was not suppressed by the administration of vasoactive intestinal peptide or dibutyryl cyclicAMP. The metabolism of PGE2 in the culture medium showed that a considerable amount of PGA2 was produced from PGE2. These observations suggest that PGE2 inhibits the cell growth of HT-29 without stimulation of cAMP production, and that this inhibitory effect was due to the metabolic change of PGE2 to PGA2.


Hepato-gastroenterology | 2002

Genetic analysis of xanthogranulomatous cholecystitis: precancerous lesion of gallbladder cancer?

Moriatsu Takada; Yoshiki Horita; Saori Okuda; Satoru Okumoto; Masahiro Samizo; Takahiro Wada; Yoshikazu Kuroda; Sakan Maeda


Hepato-gastroenterology | 2003

Genetic analysis of cancer occurring in the ileocecal valve.

Moriatsu Takada; Yoshiki Horita; Satoru Okumoto; Fujimori T; Yonson Ku; Yoshikazu Kuroda


Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 1993

Studies of Clinicopathological Features and Surgical Management on Obstructing Carcinoma of the Large Bowel.

Katsuya Kuroda; Yoshiki Horita; Michio Kato; Masayoshi Sakane; Satoru Okumoto; Toshimasa Yamaguchi; Yoichi Saitoh


Nippon Daicho Komonbyo Gakkai Zasshi | 1991

A Study of Colorectal Cancer in Patients over 80 Years Old

Yoshiki Horita; Masayoshi Sakane; K. Kuroda; Satoru Okumoto; T. Yamaguchi; Michio Katoh; Yoichi Saitoh


Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 1991

Colorectal cancer in patients less than 30 years of age.

Satoru Okumoto; Yoshiki Horita; Michio Kato; Hiroyuki Deguchi; Yoshimasa Hashimoto; Katsuya Kuroda; Masayoshi Sakane; Toshimasa Yamaguchi; Yoichi Saitho


Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 1995

An Experience of Thoracoscopy-assisted Esophagectomy for Esophageal Cancer.

Daisuke Kuroda; Michio Kato; Satoru Okumoto; Chikao Yasuda; Michizo Hayashi; Katsuji Yamauchi; Haruya Murakami; Hideaki Nomura; Shinichi Nishimatsu; Harumasa Ohyanagi


Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 1991

Clinicopathological study of postoperative recurrence of colorectal cancer. Diagnostic usefulness of carcino-embryonic antigen.

Masayoshi Sakane; Yoshiki Horita; Michio Kato; Toshimasa Yamaguchi; Satoru Okumoto; Katsuya Kuroda; Yoichi Saitoh


Nippon Daicho Komonbyo Gakkai Zasshi | 1989

A Study of Early Complications after Stomal Surgery

Yoshiki Horita; Satoru Okumoto; K. Kuroda; Michio Katoh; Yoichi Saitoh


Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 1989

Clinicopathological studies on histological heterogeneity in colorectal carcinoma with lymphnode metastasis.

Yoshiki Horita; Yoshimasa Hashimoto; Satoru Okumoto; Michio Katoh; Yoichi Saitoh

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