Satyendra Kumar Pandey

An enantioselective approach to 2-alkyl substituted tetrahydroquinolines: total synthesis of (+)-angustureine

A simple and highly efficient synthetic approach to enantiopure 2-alkyl substituted tetrahydroquinoline 1 skeleton from aldehydes as starting materials and its application to the total synthesis of (+)-angustureine 2 is described. Key transformations include proline catalyzed aminoxylation, Corey–Fuchs protocol, Sonogashira coupling and intramolecular Mitsunobu reactions.

An enantioselective approach to functionalized amino acids: total synthesis of antiepileptic drug (R)-lacosamide.

A short and highly efficient synthetic approach to enantiopure functionalized amino acids (FAAs) 1 skeleton from racemic butadiene monoepoxide as a starting material and its application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described. The synthesis utilizes the palladium catalyzed Trosts Dynamic Kinetic Asymmetric Transformation (DYKAT) as key step.

Enantioselective total synthesis of (+)-serinolamide A

A short and highly efficient enantioselective synthetic approach to (+)-serinolamide A 1 from racemic butadiene monoepoxide as a starting material is described. The synthesis utilizes the palladium catalyzed Trosts Dynamic Kinetic Asymmetric Transformation (DYKAT) and cross-metathesis (CM) as key steps.

Enantioselective total synthesis of (S)-nakinadine B

A novel approach for the synthesis of α-phenyl-β2-amino acid core unit 1 and its application to the total synthesis of (S)-nakinadine B 3, a marine natural product, is described. The synthesis utilizes the optimized combination of diphenylprolinol silyl ether mediated asymmetric Michael addition and a proline catalyzed aminoxylation reactions as key steps.

Total synthesis of haliclamide

A stereoselective approach for the synthesis of haliclamide 1, a marine natural product, has been developed. The notable features of our synthesis include MacMillan cross aldol, Mitsunobu inversion, Yamaguchi-Hirao alkylation, Steglich esterification and macrolactamization reactions and the Corey-Fuchs protocol as the key steps.

Enhanced Anti-oxidant Activity as a Function of Selenium hyperaccumulation in Agaricus bisporus Cultivated on Se-rich Agri-residues

Abstract Modulations in antioxidant properties of button mushroom, Agaricus bisporus, cultivated on selenium-rich wheat straw from the seleniferous belt of Punjab (India) were examined in comparison to the mushrooms cultivated on normal straw. Selenium (Se) uptake by Se-fortified mushrooms (122 ± 1.8 µg/g DW) was significantly higher than control (14 ± 0.7 µg/g DW). The antioxidant activity, as determined by various assays viz., free radical scavenging, metal chelating activity, reduced lipid peroxidation; as well as inhibition of cancer cell proliferation was higher in experimental mushrooms as compared to control. Further analysis of Se rich extracts, using FTIR and MS indicated possible presence of selenoergothioneine-like moiety as an expression of Se uptake by mushrooms. The present study demonstrates the increased anti-oxidant activity in mushrooms cultivativated on Se hyperaccumulated agricultural residues.