Yuvraj Garg

An enantioselective approach to 2-alkyl substituted tetrahydroquinolines: total synthesis of (+)-angustureine

A simple and highly efficient synthetic approach to enantiopure 2-alkyl substituted tetrahydroquinoline 1 skeleton from aldehydes as starting materials and its application to the total synthesis of (+)-angustureine 2 is described. Key transformations include proline catalyzed aminoxylation, Corey–Fuchs protocol, Sonogashira coupling and intramolecular Mitsunobu reactions.

An enantioselective approach to functionalized amino acids: total synthesis of antiepileptic drug (R)-lacosamide.

A short and highly efficient synthetic approach to enantiopure functionalized amino acids (FAAs) 1 skeleton from racemic butadiene monoepoxide as a starting material and its application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described. The synthesis utilizes the palladium catalyzed Trosts Dynamic Kinetic Asymmetric Transformation (DYKAT) as key step.

Enantioselective total synthesis of (S)-nakinadine B

A novel approach for the synthesis of α-phenyl-β2-amino acid core unit 1 and its application to the total synthesis of (S)-nakinadine B 3, a marine natural product, is described. The synthesis utilizes the optimized combination of diphenylprolinol silyl ether mediated asymmetric Michael addition and a proline catalyzed aminoxylation reactions as key steps.