Saulo Rios Mariz

Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats

This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis shows hepatotoxity and pulmonary damages. The lethality was 46.6% among males under the higher experimental dose (405 mg/kg) and 13.3% both in females under the higher dose and among the animals treated with 135 mg/kg of the product. These data show the significant oral chronic toxicity of EE of J. gossypiifolia in rats.

Poisoning with household cleaning products in a city in Northeast Brazil

This study analyzes toxic exposures to household cleaning products based on data from the Center for Notification and Treatment of Poisoning (CEATOX) in Campina Grande, Paraíba State, Brazil, from 2007 to 2010. The data were collected from the reporting forms from the Information System on Notifiable Diseases (SINAN), analyzed with SPSS (Version 17). Chemical identification was performed in urine samples using high-resolution chromatography techniques (GC-MS and HPLC-UV). Six hundred and sixty cases of poisoning were reported, with pesticides as the principal causal agents (42.2%). Poisoning with household cleaning products occurred mainly in children (30.1%) and/or females (55.21%) who were exposed to the product accidentally (55.4%) by the oral route (82%). These data indicate that poisoning with household cleaning products in Campina Grande should be treated with specific prevention and control measures, including evaluation of ease of access to pesticides, in order to reach the goals set by the Brazilian National Health Plan for 2012-2015.

Avaliação das intoxicações por domissanitários em uma cidade do Nordeste do Brasil

Este trabalho analisa as exposicoes toxicas a domissanitarios registradas pelo Centro de Informacao e Assistencia Toxicologica de Campina Grande, Paraiba, Brasil, no periodo de 2007 a 2010. Os dados foram coletados das fichas de notificacao do Sistema de Informacao de Agravos de Notificacao (SINAN), analisados pelo software SPSS (Versao 17), e a identificacao quimica em amostras de urina foi feita por tecnicas cromatograficas de alta resolucao (CG-MS e HPLC-UV). Foram registradas 660 intoxicacoes e, considerando as variaveis de estudo, observados como principais agentes causais os agrotoxicos (42,2%).Os intoxicados por saneantes domesticos na regiao sao predominantemente criancas (30,1%), e/ou do genero feminino (55,21%), que se expoem ao produto acidentalmente (55,4%) pela via oral (82%). Diante desses dados, conclui-se que a intoxicacao por domissanitarios em Campina Grande e regiao deve ser tratada com acoes especificas de prevencao e controle junto a populacao, como a avaliacao da facilidade de acesso aos venenos agricolas, para que se consiga atingir as metas estabelecidas pelo Plano Nacional de Saude, para o quadrienio 2012-2015.

Suicide attempts: epidemiologic trends towards geoprocessing

In order to study data about suicide attempts and do the mapping of occurrence areas, it was developed an ecologic and exploring study, making use of techniques of geoprocessing, based on confirmed cases of suicide attempts. Cases of self-poisoning were included in the urban area of Campina Grande county, in the period of 2010-2013. A total of 446 suicide attempts were geo-referred, pointing up an incidence of 120 cases out of each 100,000 inhabitants. The sample was mostly feminine (66.4%), and 62.3% being up to 30 years old. Kernels map remarked hot spot areas. Compared to surrounding areas the suicide risk of populations within the hot spots was increased (38%; Relative Risk = 1.38; p= 0.0029), with an average estimative of 165 suicide attempts out of 100,000 inhabitants. Through identification of hot spots and index of living conditions of the neighborhoods, it is possible to set priorities in terms of public policies for the prevention of suicide attempts and control of the marketing of substances that are potentially toxic.