Sergii Pazenok

In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation

The use of TFEDMA, a fluoroalkyl amino reagent, for the difluoromethylation and difluoroacylation of arenes, heteroarenes, and C-H acidic compounds is reported. This approach allows for an efficient access to difluoromethylated products of high added value in good to excellent yields and with scale-up possibilities.

Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles

Fluoroalkyl amino reagents 1a and 2a have been developed from commercially available trifluoromethyl trifluorovinyl ether via a hydroamination reaction with diethylamine or dimethylamine. These reagents can be activated by treatment with a Lewis acid and subsequently used as a mono- or dielectrophile for the introduction of the fluoro(trifluoromethoxy)methyl group, either in Vilsmeier-type acylations of aromatic substrates or in the synthesis of fluorinated pyrazoles from CH-acidic substrates and of bis-fluorinated pyrazoles, all being important building blocks for medicinal and agricultural chemistry.

A physico-chemical investigation of fluorine-enriched quinolines

Quinoline derivatives bearing fluoroalkyl groups at both 2 and 4 positions are scarcely described in the literature. Nevertheless, the addition of fluorine onto the quinoline core might bring about new interesting physico-chemical properties. To confirm this hypothesis a homogenous series of 2,4-bis(fluoroalkyl)-substituted quinolines was synthesized under mild reaction conditions and their physico-chemical properties were thoroughly investigated by various techniques to illustrate their potential usefulness as new building blocks for applications ranging from organic chemistry to materials science.