Shanshan Jiang

Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer reference (EMR) signals: II. Comparison of three EMR models and application to human brain glioma at 3 Tesla.

To evaluate the use of three extrapolated semisolid magnetization transfer reference (EMR) methods to quantify amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) signals in human glioma.

Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas

To assess amide proton transfer‐weighted (APTW) imaging features in patients with malignant gliomas after chemoradiation and the diagnostic performance of APT imaging for distinguishing true progression from pseudoprogression.

Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI

To explore the capability of amide proton transfer (APT) imaging in the detection of hemorrhagic and ischemic strokes using preclinical rat models.

Quantitative assessment of the effects of water proton concentration and water T1 changes on amide proton transfer (APT) and nuclear overhauser enhancement (NOE) MRI: The origin of the APT imaging signal in brain tumor

To quantify pure chemical exchange–dependent saturation transfer (CEST) related amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) signals in a rat glioma model and to investigate the mixed effects of water content and water T1 on APT and NOE imaging signals.

Insight into the quantitative metrics of chemical exchange saturation transfer (CEST) imaging.

To evaluate the reliability of four CEST imaging metrics for brain tumors, at varied saturation power levels and magnetic field strengths (3−9.4 Tesla (T)).

Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques

To evaluate the feasibility of accelerated chemical‐exchange‐saturation‐transfer (CEST) imaging using a combination of compressed sensing (CS) and sensitivity encoding (SENSE) at 3 Tesla.

Selecting the reference image for registration of CEST series.

To compare different reference images selected for registration among chemical exchange saturation transfer (CEST) series.

Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI

To assess the amide proton transfer‐weighted (APTw) MRI features of isocitrate dehydrogenase (IDH)‐wildtype and IDH‐mutant grade II gliomas and to test the hypothesis that the APTw signal is a surrogate imaging marker for identifying IDH mutation status preoperatively.

Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals

To quantify amide protein transfer (APT) effects in acidic ischemic lesions and assess the spatial‐temporal relationship among diffusion, perfusion, and pH deficits in acute stroke patients.

Highly accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling

In clinical studies, compartmental average chemical exchange saturation transfer (CEST) measurements rather than voxel‐by‐voxel CEST images may suffice for evaluating its diagnostic value. A recently developed method—spectroscopy with linear algebraic modeling, or SLAM—could directly provide compartmental measures with dramatically reduced scan time and optimal signal‐to‐noise ratios. Here, we test whether SLAM can be adapted to significantly accelerate CEST acquisitions.