She-Po Shi
Peking University
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Publication
Featured researches published by She-Po Shi.
Journal of Natural Products | 2010
Qiang Fu; Ke Zan; Ming-Bo Zhao; Si-Xiang Zhou; She-Po Shi; Yong Jiang; Peng-Fei Tu
Seven new triterpene saponins, clematochinenosides A-G (1-7), together with 17 known saponins (8-24), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Compounds 1, 3-7, and 20-24 showed inhibitory activities against COX-1 and COX-2 enzymes.
Journal of Asian Natural Products Research | 2006
She-Po Shi; Peng-Fei Tu; Cai-Xia Dong; Dan Jiang
Three new alkaloids together with two known compounds have been isolated from the roots of Clematis manshurica. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as methyl 7-ethoxy-3-indolecarbonate (2), methyl 7-O-α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranosyl 3-indolecarbonate (3) and α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranosyl 3-indolecarbonate (4).
Journal of Asian Natural Products Research | 2013
Qiang Fu; Ke Zan; Ming-Bo Zhao; Si-Xiang Zhou; She-Po Shi; Yong Jiang; Peng-Fei Tu
Three new triterpene saponins, clematochinenosides H–J (1–3), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on the basis of spectroscopic means including 1D and 2D NMR experiments and hydrolysis products.
Phytochemistry | 2014
Ablajan Turak; She-Po Shi; Yong Jiang; Peng-Fei Tu
Five dimeric guaianolides, absinthins A-E, and seven known dimeric guaianolides were isolated from Artemisia absinthium. Their structures were elucidated based on 1D- and 2D-NMR experiments, including (1)H NMR, (13)C NMR, DEPT, (1)H-(1)H COSY, HSQC, HMBC, and NOESY, and through HRESIMS data analysis. The absolute configuration of the known compound, anabsinthin, was determined by X-ray crystallographic analysis. The isolated compounds were tested to assess their inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 cells; absinthin C and isoanabsinthin exhibited significant inhibitory effects with IC50 values of 1.52 and 1.98μM, respectively.
Zeitschrift für Naturforschung B | 2006
She-Po Shi; Dan Jiang; Cai-xia Dong; Peng-Fei Tu
Two new lignans, clemomanshurinane A and B, along with ten known compounds have been isolated from the roots and rhizomes of Clematis manshurica. The structures were elucidated on the basis of their physicochemical and spectroscopic evidence. Clemomanshurinane A and B, (+)-dihydrodehydrodiconiferyl alcohol and (+)-lariciresinol 4,4′-O-bis-β -D-glucopyranoside indicated inhibitory effects on COX-2 at final concentration of 10−5 mol/l, with the inhibition rates 65.8%, 71.8%, 53.3%, and 60.3%, respectively.
Journal of Natural Products | 2017
Bowen Qi; Xiao Liu; Ting Mo; Zhi-Xiang Zhu; Jun Li; Juan Wang; Xiao-Ping Shi; Ke-Wu Zeng; Xiaohui Wang; Peng-Fei Tu; Ikuro Abe; She-Po Shi
Eight new chrysogenolides (A-H (1-8)) and seven known (9-15) 3,5-dimethylorsellinic acid derived meroterpenoids were isolated from the solid substrate fermentation cultures of a Huperzia serrata endophytic fungus, Penicillium chrysogenum MT-12. The structures of the new compounds were elucidated by interpretation of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of 1-4 were determined by single-crystal X-ray crystallographic analysis, and those of 5-8 were assigned on the basis of experimental and calculated electronic circular dichroism spectra. Compounds 3, 4, 6, 11, and 12 showed inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophage cells with IC50 values in the range of 4.3-78.2 μM (positive control, indomethacin, IC50 = 33.6 ± 1.4 μM).
Zeitschrift für Naturforschung B | 2007
Cai-xia Dong; She-Po Shi; Ke-si Wu; Peng-Fei Tu
A new phenolic glycoside, 2,6-dimethoxy-4-(3-hydroxy-propen-1-yl)phenyl-4-O-α-L-rhamnopyranosyl-( 1 → 6)-β -D-glucopyranoside (1) and a new D-ribono-γ -lactone derivative, 3-O-β -D-glucopyranosyl- 2-hydroxymethyl-D-ribono-γ -lactone (3), together with thirteen known compounds have been isolated from the roots and rhizomes of Clematis hexapetala Pall. The characterization of these compounds was achieved by various chromatographic and spectroscopic methods
Chinese Journal of Natural Medicines | 2008
Cai-Xia Dong; She-Po Shi; Ming-Bo Zhao; Peng-Fei Tu
AIM: To study the chemical constituents of the roots and rhizomes of Clematis hexapetala Pall.. METHODS: The solvent extraction, silica gel column chromatography and pre-HPLC were used to isolate and purify the constituent, and various spectroscopic analyses were used to elucidate the structure. RESULTS: A glucopyranosyl naphthalene (1) derivative, 5,8-dihydro-6-methyl-1,4-β-D-diglucopyranosyl naphthalene has (1) been isolated from this plant. CONCLUSION: This compound is a new one, and this study enriched the chemical constituents of Clematis hexapetala.
Journal of Natural Products | 2017
Hui-Xia Huo; Zhi-Xiang Zhu; Yuelin Song; She-Po Shi; Jing Sun; Hui Sun; Yunfang Zhao; Jiao Zheng; Daneel Ferreira; Jordan K. Zjawiony; Peng-Fei Tu; Jun Li
Sixteen new 2-(2-phenylethyl)chromone dimers, including four pairs of enantiomers (1a/1b, 3a/3b, 6a/6b, and 8a/8b), along with eight optically pure analogues (2, 4, 5, 7, and 9-12) were isolated from the resinous wood of Aquilaria sinensis. Their structures were determined by extensive spectroscopic analysis (1D and 2D NMR, UV, IR, and HRMS) and experimental and computed ECD data. Compounds 1-10 feature an unusual 3,4-dihydro-2 H-pyran ring linkage connecting two 2-(2-phenylethyl)chromone monomeric units, while compounds 11 and 12 possess an unprecedented 6,7-dihydro-5 H-1,4-dioxepine moiety in their structures. A putative biosynthetic pathway of the representative structures via a diepoxy derivative of a chromone with a nonoxygenated A-ring is also proposed. Compounds 1a/1b, 2, 3a/3b, 5, 7, 8a/8b, and 10-12 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values in the range 7.0-12.0 μM.
Biochemical Systematics and Ecology | 2006
Yuan Zhang; She-Po Shi; Ming-Bo Zhao; Yong Jiang; Peng-Fei Tu