Shigemi Fujisaki

Studies of Ldh Activity Concerning Malignant Transformation from Chronic Sinusitis

The LDH activity of maxillary cancer tissues was considerably higher than in the other tissues including the surrounding tissues, irradiated cancer tissues, and the mucosa of the maxillary sinus in chronic sinusitis. from the standpoint of classified LDH isozyme patterns, the maxillary cancer tissues were characterized by predominant fractions of LDH4 and LDHs in contrast to the chronic sinusitis tissues in which LDHa prevailed. We designated the type of the former “Cancer type” and the latter, “Inflammation type”, and proposed designation of ten types of the LDH isoenzyme pattern (from 1 to 10). the enzymologic studies on the basis of the LDH activity and isozyme aspect classified that the histologically proliferative type in chronic sinusitis resembles the cancer type.

TREATMENT OF CHRONIC SINUSITIS MAXILLARIS WITH PRONASE-P

The clinical improvement of sinusitis maxillaris following oral treatment with Pronase-P.described in the previous report led to a pathological review of nasal mucosa. 1)Instillation of Pronase-P into the maxillary sinus for 8 cases of chronic sinusitis maxillaris resulted in symptomatic improvement in almost Ited in a marked symptomatic improvement. 2)Nine cases of chronic sinusitis maxillaris with bilateral involvement of the same degree were plus Predonine to 2 cases for a week and then method for the removal of nasal mucosae. It was found that there was a decrease of edma in mucosae, a diminuion of intrasinus pus and an side. 3)Sixteen cases of chronic sinusitis maxillris were laterally operated on immediately followed side was operate on each 6days, 9days, 12days, 15days and 18days later. It was revealed the efficacy of Pronase-P was not so significant within a week of administration but reflected less retention of the intrasinus pus, a decrease in mucosal edema, infiltration of round after the first week.