Shinichi Kotani

Integrated molecular analysis of adult T cell leukemia/lymphoma

Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here we describe an integrated molecular study in which we performed whole-genome, exome, transcriptome and targeted resequencing, as well as array-based copy number and methylation analyses, in a total of 426 ATL cases. The identified alterations overlap significantly with the HTLV-1 Tax interactome and are highly enriched for T cell receptor–NF-κB signaling, T cell trafficking and other T cell–related pathways as well as immunosurveillance. Other notable features include a predominance of activating mutations (in PLCG1, PRKCB, CARD11, VAV1, IRF4, FYN, CCR4 and CCR7) and gene fusions (CTLA4-CD28 and ICOS-CD28). We also discovered frequent intragenic deletions involving IKZF2, CARD11 and TP73 and mutations in GATA3, HNRNPA2B1, GPR183, CSNK2A1, CSNK2B and CSNK1A1. Our findings not only provide unique insights into key molecules in T cell signaling but will also guide the development of new diagnostics and therapeutics in this intractable tumor.

Ljapunov Indices Determine Absolutely Continuous Spectra of Stationary Random One-dimensional Schrödinger Operators

Publisher Summary This chapter proves that the Ljapunov index of L(q) is positive only when there exists no absolutely continuous spectrum. If the stationary random potential is non-deterministic, then there exists no absolutely continuous spectrum. These results are shown by making use of the formulae on the expectations of the Green functions. In the process of the proofs, a connection between the Ljapunov index and the density of states for stationary random potentials plays an essential role. The chapter proves that, under the condition that the spectrum consists of a half-line, if the Ljapunov index vanishes on the support of the density of states, then the stationary random potential has to be a constant. This theorem asserts that if a stationary random potential is not a constant and its spectrum has no gaps, then there exists some Borel set with positive Lebesgue measure in its spectrum and L(q) admits no absolutely continuous spectrum on the set.

One-dimensional Schrödinger operators with random decaying potentials

AbstractWe investigate the spectrum of the following random Schrödinger operators:

Inverse spectral theory for random Jacobi matrices

H(\omega ) = - \frac{{d^2 }}{{dt^2 }} + a(t)F(X_t (\omega )),

Acute renal failure associated with systemic polyoma BK virus activation in a patient with peripheral T-cell lymphoma

whereF(Xt(ω)) is a Markovian potential studied by the Russian school [8]. We completely describe the transition of the spectrum from pure point type to absolutely continuous type as the decreasing order ofa(t) grows. This is an extension to a continuous case of the result due to Delyon-Simon-Souillard [6], who deal with the lattice case.

On asymptotics of Eigenvalues for a certain 1-dimensional random Schrödinger operator

In the multi-dimensional case it is shown that the increase of the topological support of the probability measure describing the randomness of potentials implies the increase of the spectrum. In the one-dimensional case the converse statement for the absolutely continuous spectrum is valid. Especially the spectrum (in general dimension) and the absolutely continuous spectrum (in one-dimension) are determined only by the topological support of the random potentials.

Problems of One-Dimensional Random Schrödinger Operators

We give necessary and sufficient conditions for a Herglotz function to be thew-function of a random stationary Jacobi matrix.

Localization in general one-dimensional random systems

A 68-year-old Japanese woman was admitted to our hospital because of congestive heart failure and sinus node dysfunction. F-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) revealed a cardiac tumor involving right atrium of the heart (Fig. 1a, b), and the tumor was diagnosed as primary cardiac diffuse large B cell lymphoma by open chest biopsy. The immunophenotype of the lymphoma cells was CD3, CD5, CD10, CD19, CD20, CD22, smIgM, and smIg-j. The