Shinobu Tanaka

Comparison between red, green and blue light reflection photoplethysmography for heart rate monitoring during motion

Reflection photoplethysmography (PPG) using 530 nm (green) wavelength light has the potential to be a superior method for monitoring heart rate (HR) during normal daily life due to its relative freedom from artifacts. However, little is known about the accuracy of pulse rate (PR) measured by 530 nm light PPG during motion. Therefore, we compared the HR measured by electrocadiography (ECG) as a reference with PR measured by 530, 645 (red), and 470 nm (blue) wavelength light PPG during baseline and while performing hand waving in 12 participants. In addition, we examined the change of signal-to-noise ratio (SNR) by motion for each of the three wavelengths used for the PPG. The results showed that the limit of agreement in Bland-Altman plots between the HR measured by ECG and PR measured by 530 nm light PPG (±0.61 bpm) was smaller than that achieved when using 645 and 470 nm light PPG (±3.20 bpm and ±2.23 bpm, respectively). The ΔSNR (the difference between baseline and task values) of 530 and 470nm light PPG was significantly smaller than ΔSNR for red light PPG. In conclusion, 530 nm light PPG could be a more suitable method than 645 and 470nm light PPG for monitoring HR in normal daily life.

A Preliminary Study on Driver's Stress Index Using a New Method Based on Differential Skin Temperature Measurement

Prolonged periods of driving in monotonous situations may lower a drivers activation state as well as increasing their stress level due to the compulsion to maintain safe driving, which may result in an increased risk of a traffic accident. There is therefore an opportunity for technological assessment of driver physiological status to be applied in-car, hopefully reducing the incidence of potentially dangerous situations. As part of our long-term aim to develop such a system, we describe here the investigation of differential skin temperature measurement as a possible marker of a drivers stress level. 10 healthy male subjects were studied, under environment-controlled conditions, whilst being subjected to simulated monotonous travel at constant speed on a test-course. We acquired measurements of relevant physiological variables, including truncal and peripheral skin temperatures (Ts), beat-by-beat blood pressure (BP), cardiac output (CO), total peripheral resistance (TPR), and normalized pulse volume (NPV) used as an indicator of local peripheral vascular tone. We then investigated the drivers reactivity in terms of cardiovascular haemodynamics and skin temperatures. We found that the simulated monotonous driving produced a gradual drop in peripheral Ts following the driving stress, which, through interpretation of the TPR and NPV recordings, could be explained by peripheral sympathetic activation. On the other hand, the truncal Ts was not influenced by the stress. These findings lead us to suggest that truncal-peripheral differential Ts might be used as a possible index indicative of the drivers stress. Such an index, if decisively validated, would be easy to apply in real driving situations by using radiation thermometer.

Noninvasive measurement of instantaneous, radial artery blood pressure

A new prototype system for the noninvasive measurement of instantaneous blood pressure (BP) in the human radial artery has been developed. The system is based on the volume-compensation method, but several components were newly designed, namely, a disk-type cuff for local pressurization and a nozzle-flapper-type electro-pneumatic converter (EPC) for the cuff-pressure control. Results of experiments indicated that, using the disk-type cuff, the radial artery could be completely compressed, and the newly devised EPC had sufficient frequency response for BP measurement in humans. It was also found that the prototype system comprising these components was capable of noninvasively measuring instantaneous BP in the human radial artery, not only under rest conditions but also in a stressful condition, such as during the cold pressor test. In conclusion, the newly developed local pressurization technique appears promising as a useful and helpful means for instantaneous BP monitoring over longer periods of time than have previously been possible. Using this method, it is possible to construct an instrument that is more compact and more comfortable for the subject to use than a conventional commercial instrument. Finally, it has been reported that it may be possible to monitor cardiac output continuously by BP waveform analysis. Thus, continuous cardiac output monitoring might be another potential and important application of the newly designed instrument.

A fully automated health-care monitoring at home without attachment of any biological sensors and its clinical evaluation

Daily monitoring of health condition is important for an effective scheme for early diagnosis, treatment and prevention of lifestyle-related diseases such as adiposis, diabetes, cardiovascular diseases and other diseases. Commercially available devices for health care monitoring at home are cumbersome in terms of self-attachment of biological sensors and self-operation of the devices. From this viewpoint, we have been developing a non-conscious physiological monitor installed in a bath, a lavatory, and a bed for home health care and evaluated its measurement accuracy by simultaneous recordings of a biological sensors directly attached to the body surface. In order to investigate its applicability to health condition monitoring, we have further developed a new monitoring system which can automatically monitor and store the health condition data. In this study, by evaluation on 3 patients with cardiac infarct or sleep apnea syndrome, patients’ health condition such as body and excretion weight in the toilet and apnea and hypopnea during sleeping were successfully monitored, indicating that the system appears useful for monitoring the health condition during daily living.

A New Non-invasive Method for Measuring Blood Glucose Using Instantaneous Differential Near Infrared Spectrophotometry

We describe further development of a novel method for non-invasive measurement of blood glucose concentration (BGL), named Pulse Glucometry, based on differential near infrared spectrophotometry. Sequential temporal differences of infrared transmittance spectra from the radiation intensity (Ilambda) emerging from a fingertip containing an arterial pulse component (DeltaIlambda) are analysed. To perform the measurements we developed a new high-speed spectrophotometer, covering the wavelength range from 900 to 1700 nm, scanning at a maximum spectral rate of 1800 spectra/s, with a minimum exposure time of 20 mus. Spectra related only to the pulsatile blood component are derived, thus minimising influences of basal components such as resting blood volume, skin, muscle and bone. We have now improved the performance of the spectrophotometer and in the present paper we describe new in vivo measurements carried out in 23 healthy volunteers undergoing glucose tolerance tests. Blood samples were collected from the cephalic vein simultaneously with radiation intensity measurements in the fingertip every 10 min before and after oral administration of glucose solution for 120 min. BGL values were then predicted using a PLS calibration model and compared with blood values determined by colorimetric assay. The precision and accuracy of the non-invasive determinations are encouraging.

Feasibility study on driver's stress detection from differential skin temperature measurement

Prolonged monotonous driving may lower a drivers awareness level as well as increasing their stress level due to the compulsion to maintain safe driving, which may result in an increased risk of a traffic accident. There is therefore an opportunity for technological assessment of driver physiological status to be applied in-car, hopefully reducing the incidence of potentially dangerous situations. As part of our long-term aim to develop such a system, we describe here the investigation of differential skin temperature measurement as a possible marker of a drivers stress level. In this study, healthy male (n=18) & female (n=7) subjects were investigated under environment-controlled conditions, whilst being subjected to simulated monotonous travel at constant speed on a test-course. We acquired physiological variables, including facial skin temperature which consists of truncal and peripheral skin temperatures (Ts) using thermography, beat-by-beat blood pressure (BP), cardiac output (CO), total peripheral resistance (TPR), and normalized pulse volume (NPV) used as an indicator of local peripheral vascular tone. We then investigated the drivers reactivity in terms of skin temperatures with this background of cardiovascular haemodynamics. We found that the simulated monotonous driving produced a gradual drop in peripheral Ts following the driving stress, which, through interpretation of the TPR and NPV recordings, could be explained by peripheral sympathetic activation. On the other hand, the truncal Ts was not influenced by the stress. These findings lead us to suggest that truncal-peripheral differential Ts could be used as a possible index indicative of the drivers stress.

Accuracy Assessment of a Noninvasive Device for Monitoring Beat-by-Beat Blood Pressure in the Radial Artery Using the Volume-Compensation Method

For the noninvasive and accurate measurement of instantaneous blood pressure (BP) in the radial artery, the performance of a device based on the principle of volume-compensation was assessed by comparison with simultaneous measurement of direct (invasive) radial artery pressure in nine healthy subjects. Bias and precision of systolic BP (SBP) and diastolic BP (DBP) derived from Bland-Altman plots of data from the present system and the direct method averaged -0.5 plusmn 2.1 mmHg and 0.6 plusmn 1.8 mmHg respectively, over a wide range of SBP and DBP. These results clearly indicate that, using this system, instantaneous radial artery pressure can be measured noninvasively with high accuracy.

Development of a fully automated network system for long-term health-care monitoring at home

Daily monitoring of health condition at home is very important not only as an effective scheme for early diagnosis and treatment of cardiovascular and other diseases, but also for prevention and control of such diseases. From this point of view, we have developed a prototype room for fully automated monitoring of various vital signs. From the results of preliminary experiments using this room, it was confirmed that (1) ECG and respiration during bathing, (2) excretion weight and blood pressure, and (3) respiration and cardiac beat during sleep could be monitored with reasonable accuracy by the sensor system installed in bathtub, toilet and bed, respectively.

A Compact Centrifugal Blood Pump for Extracorporeal Circulation: Design and Performance

A new compact centrifugal blood pump driven by a miniature DC servomotor has been designed for use for short-term extra corporeal and cardiac-assisted circulation. The impeller of the pump was connected directly to the motor by using a simple-gear coupling. The shaft for the impeller was sealed from blood by both a V-ring and a seal bearing. Either pulsatile or nonpusatile flow was produced by controlling the current supply to the motor. The pump characteristics and the degree of hemolysis were evaluated with regard to the configuration of the impeller with a 38-mm outer diameter in vitro tests; the impeller having the blade angles at the inlet of 20 deg and at the outlet of 50 deg was the most appropriate as a blood pump. The performance in an operation, hemolysis and thrombus formation in the pump were assessed by a left ventricular bypass experiment in dogs. It was suggested by this study that this prototype pump appears promising for use not only in animal experiments but also in clinical application.

Development of a Wearable Device Capable of Monitoring Human Activity for Use in Rehabilitation and Certification of Eligibility for Long-Term Care

The importance of human posture monitoring is well recognized in the field of rehabilitation, in order to evaluate quantitatively the effectiveness of rehabilitation by a physical therapist. The activity monitoring is also well recognized as being useful in the field of certification of eligibility for long-term care. Assessment of the actual physical condition of the applicant tends to be difficult when determining the level of need for long-term care. Taking these circumstances in consideration, we attempted to measure the activities of patients in rehabilitation using a wearable device for monitoring human activity. The results clearly demonstrated that detailed motion characteristics could be detected during standing up, walking and sitting up as angle changes between specific body segments and as trunk motion acceleration