Shinsuke Hashimoto

A new synthetic route to prostaglandins

Abstract A short synthetic route to prostaglandins is described which depends on oxime-based methodology and which involves the joining of intermediates 9 , 11 , and 12 in a one-flask operation.

Synthesis of clavulones (claviridenones)

Abstract New marine eicosanoid clavulones (claviridenones) were synthesized from the Corey lactone and D -glutamic acid.

Design and synthesis of a selective EP4-receptor agonist. Part 4: practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist

A practical method of synthesizing a highly selective EP4-receptor agonist 1 using Corey lactone 2 as a key intermediate was developed. Selective methanesulfonylation of the primary alcohol of the diol 8 under the newly devised conditions followed by the protection of the remaining secondary alcohol are key reactions in this new method. Further biological evaluation of 1a-b is also reported.

Synthesis of 9α,11α-thiathromboxane A2 methyl ester

Abstract The synthesis of thromboxane A 2 (TXA) analogue, 9α,11α-thia-TXA 2 methyl ester 2 , in which the oxygen atom in the oxetane ring of TXA 2 was replaced by a sulfur atom, is described.