Shinya Nakashima

First Performance Evaluation of an X-Ray SOI Pixel Sensor for Imaging Spectroscopy and Intra-Pixel Trigger

We have been developing a monolithic active pixel sensor with the 0.2 μm Silicon-On-Insulator (SOI) CMOS technology, called SOIPIX, for the wide-band X-ray imaging spectroscopy on future astronomical satellites. SOIPIX includes a thin CMOS-readout-array layer and a thick high-resistivity Si-sensor layer stacked vertically on a single chip. This arrangement allows for fast and intelligent readout circuitries on-chip, providing advantages over the charge-coupled device (CCD). We have designed and built a new SOIPIX prototype XRPIX1 for X-ray detection. XRPIX1 implements a correlated double sampling (CDS) readout circuit in each pixel to suppress the reset noise. We obtained an energy resolution of full width at half maximum of 1.2 keV (5.4%) at 22 keV with a chip having a 147 μm sensor depletion at a back bias of 100 V cooled to -50°C. Moreover, XRPIX1 offers intra-pixel hit trigger (timing) and two-dimensional hit-pattern (position) outputs. We also confirmed the trigger capability by irradiating a single pixel with laser light.

The First Total Synthesis of Ganglioside GalNAc‐GD1a, a Target Molecule for Autoantibodies in Guillain–Barré Syndrome

The first synthesis of ganglioside GalNAc-GD1a, featuring efficient glycan assembly and a cyclic glucosyl ceramide as a versatile unit for ganglioside synthesis is described. Although ganglioside GalNAc-GD1a was first found as a brain ganglioside, IgG autoantibodies to GalNAc-GD1a were subsequently found to be closely related to a human peripheral-nerve disorder, Guillain-Barré syndrome, which is the commonest cause of acute flaccid paralysis worldwide. In this study, the characteristic hexasaccharide part carrying two sialic acid residues was synthesized efficiently by use of a readily accessible GM2-core unit as a common unit. The potentially difficult coupling of the oligosaccharide and ceramide moieties was carried out by using a cyclic glucosyl ceramide as a coupling partner for the hexasaccharide part, thereby successfully providing the framework of the target compound. Global deprotection delivered the homogenous ganglioside GalNAc-GD1a. An enzyme-linked immunosorbent assay showed that sera from patients with Guillain-Barré syndrome reacted both with natural and with synthetic GalNAc-GD1a.

X-Ray Echo from the Sagittarius C Complex and 500-year Activity History of Sagittarius A

This paper presents the Suzaku results obtained for the Sagittarius (Sgr) C region using the concept of X-ray reflection nebulae (XRNe) as the echo of past flares from the super massive black hole, Sgr A*. The Sgr C complex is composed of several molecular clouds proximately located in projected distance. The X-ray spectra of Sgr C were analyzed on the basis of a view that XRNe are located inside the Galactic center plasma X-ray emission with an oval distribution around Sgr A*. We found that the XRNe are largely separated in the line-of-sight position, and are associated with molecular clouds in different velocity ranges detected by radio observations. We also applied the same analysis to the Sgr B XRNe and completed a long-term light curve for Sgr A* occurring in the past. As a new finding, we determined that Sgr A* was experiencing periods of high luminosity already 500 years ago, which is longer than the previously reported value. Our results are consistent with a scenario that Sgr A* was continuously active with sporadic flux variabilities of Lx = 1-3 x 10^39 erg s^-1 in the past 50 to 500 years. The average past luminosity was approximately 4-6 orders of magnitude higher than that presently observed. In addition, two short-term flares of 5-10 years are found. Thus, the past X-ray flare should not be a single short-term flare, but can be interpreted as multiple flares superposed on a long-term high state.

Design and Evaluation of an SOI Pixel Sensor for Trigger-Driven X-Ray Readout

We have been developing a monolithic active pixel sensor with the silicon-on-insulator (SOI) CMOS technology for use in future X-ray astronomical satellite missions. This sensor is called XRPIX. Our objective is to replace the X-ray CCD, which is currently the standard detector in the field, with the developed XRPIX, which offers high coincidence time resolution (~ 50 ns), superior hit-position readout time (~ 10 μs), and wide bandpass (0.5-40 keV), in addition to having comparable performance in terms of imaging spectroscopy. In our previous study, we built a prototype sensor called XRPIX1 and confirmed its basic X-ray imaging spectroscopy performance in a mode that read out the entire area (all pixels). The next step is to realize a high-speed, intelligent readout for X-ray detection. XRPIX1 comprises a trigger circuit for each pixel, so as to detect an X-ray photon injection; this system is capable of direct access to selected pixels to read out the signal amplitude. We describe the design of the trigger circuitry system and report on the first resolved X-ray spectra obtained in the trigger-driven readout mode.

Efficiently Synthesizing Lacto‐Ganglio‐Series Gangliosides by Using a Glucosyl Ceramide Cassette Approach: The Total Synthesis of Ganglioside X2

The first total synthesis of the hybrid ganglioside X2, which consisted of a highly branched octasaccharide and ceramide moieties, was accomplished by using a glucosyl ceramide cassette approach. With a disaccharyl donor, the heptasaccharide could not be constructed by glycosylation of the C4 hydroxy group of galactose at the reducing end of the pentasaccharide. In contrast, through an alternative approach with two branched glycan units, a GM2-core trisaccharide, and a lacto-ganglio tetrasaccharide, the heptasaccharyl donor could be prepared and subsequently joined with a glucosyl ceramide cassette to afford the protected ganglioside, X2. Finally, global deprotection completed the synthesis, thus affording the pure ganglioside X2.

SUZAKU X-RAY OBSERVATIONS OF THE FERMI BUBBLES: NORTHERNMOST CAP AND SOUTHEAST CLAW DISCOVERED WITH MAXI-SSC

We report on Suzaku observations of large-scale X-ray structures possibly related with the Fermi Bubbles obtained in 2013 with a total duration of ~ 80 ks. The observed regions were the: (i) northern cap (N-cap; l ~ 0 deg, 45 deg < b < 55 deg) seen in the Mid-band (1.7-4.0 keV) map recently provided by MAXI-SSC and (ii) southeast claw (SE-claw; l ~ 10 deg, -20 deg < b < -10 deg) seen in the ROSAT all-sky map and MAXI-SSC Low-band (0.7-1.7 keV) map. In each region, we detected diffuse X-ray emissions which are represented by a three component plasma model consisting of an unabsorbed thermal component (kT ~ 0.1 keV) from the Local Bubble, absorbed kT = 0.30+/-0.05 keV emission representing the Galactic Halo, and a power-law component due to the isotropic cosmic X-ray background radiation. The emission measure of the GH component in the SE-claw shows an excess by a factor of ~ 2.5 over the surrounding emission at 2 deg away. We also found a broad excess in the 1.7-4.0 keV count rates across the N-cap after compiling other archival data from Suzaku and Swift. The spectral stacking analysis of the N-cap data indicates the presence of another thermal component with kT = 0.70 (+0.22,-0.11) keV. The temperature of kT ~ 0.3 keV of the Galactic Halo is higher than the ubiquitous value of kT ~ 0.2 keV near the Fermi Bubbles, and can be even higher (~ 0.7 keV). We discuss our findings in the context of bubble-halo interaction.

GLOBAL STRUCTURE OF ISOTHERMAL DIFFUSE X-RAY EMISSION ALONG THE FERMI BUBBLES

In our previous works, we found absorbed thermal X-ray plasma with kT 0.3 keV observed ubiquitously near the edges of the Fermi bubbles and interpreted this emission as weakly shock-heated Galactic halo gas. Here we present a systematic and uniform analysis of archival Suzaku (29 pointings; 6 newly presented) and Swift (68 pointings; 49 newly presented) data within Galactic longitudes l ∣∣ 0 °) favors (ii), whereas that of the south (b <0 °) is rather close to (i), but a weak excess signature is clearly detected also in the south like NPS (South Polar Spur). Such an asymmetry, if due to the bubbles, cannot be fully understood only by the inclination of bubbles’ axis against the Galactic disk normal, thus suggesting asymmetric outflow due to different environmental/initial conditions.

A First Total Synthesis of a Hybrid-Type Ganglioside Associated with Amyotrophic Lateral Sclerosis-Like Disorder†

The hybrid ganglioside X1, which was identified in the bovine brain, was synthesized for the first time. Ganglioside X1 is believed to be involved in the development of amyotrophic lateral sclerosis-like disorders in patients with neurological disorders after treatment with bovine brain gangliosides. A convergent approach using two branched glycan units, the GM2-core trisaccharide and the lacto-ganglio tetrasaccharide, efficiently provided the highly branched heptasaccharide part of ganglioside X1, which was conjugated with the ceramide part to produce the protected ganglioside X1. Global deprotection delivered homogenous ganglioside X1, with which serum from the patient was reacted.

Galactic Centre Hypershell Model for the North Polar Spurs

The bipolar-hyper shell (BHS) model for the North Polar Spurs (NPS-E, -W, and Loop I) and counter southern spurs (SPS-E and -W) is revisited based on numerical hydrodynamical simulations. Propagations of shock waves produced by energetic explosive events in the Galactic Center are examined. Distributions of soft X-ray brightness on the sky at 0.25, 0.7, and 1.5 keV in a +/-50 deg x +/-50 deg region around the Galactic Center are modeled by thermal emission from high-temperature plasma in the shock-compressed shell considering shadowing by the interstellar HI and H2 gases. The result is compared with the ROSAT wide field X-ray images in R2, 4 and 6 bands. The NPS and southern spurs are well reproduced by the simulation as shadowed dumbbell-shaped shock waves. We discuss the origin and energetics of the event in relation to the starburst and/or AGN activities in the Galactic Center. [ High resolution pdf is available at this http URL ]

Abundances in the ejecta of core-collapse supernova remnants G350.1-0.3 and G349.7+0.2

We present Suzaku results of the two Galactic supernova remnants (SNRs), G350.1-0.3 and G349.7+0.2. We find Al and Ni K alpha lines from both the SNRs for the first time, in addition to previously detected K-shell lines of Mg, Si, S, Ar, Ca and Fe. The spectra are well described by two optically thin thermal plasmas: a low-temperature (low-kT) plasma in collisional ionization equilibrium and a high-temperature (high-kT) plasma in non-equilibrium ionization. Since the low-kT plasma has solar metal abundances, it is thought to be of interstellar medium origin. The high-kT plasma has super-solar abundances, hence it is likely to be of ejecta origin. The abundance patterns of the ejecta components are similar to those of core-collapse supernovae with the progenitor mass of ~15-25 M_solar for G350.1-0.3 and ~35-40 M_solar for G349.7+0.2. We find extremely high abundances of Ni compared to Fe (Z_Ni/Z_Fe ~8). Based on the measured column densities between the SNRs and the near sky background, we propose that G350.1-0.3 and G349.7+0.2 are located at the distance of 9+/-3 kpc and 12+/-5 kpc, respectively. Then the ejecta masses are estimated to be ~13 M_solar and ~24 M_solar for G350.1-0.3 and G349.7+0.2, respectively. These values are consistent with the progenitor mass of ~15-25 M_solar and ~35-40 M_solar for G350.1-0.3 and G349.7+0.2, respectively.