Shisheng He

Comparison of selective anterior versus posterior screw instrumentation in Lenke5C adolescent idiopathic scoliosis.

Study Design. Retrospective review of anterior and posterior fusions for treatment of Lenke5C adolescent idiopathic scoliosis (AIS). Objective. To compare the clinical and radiographic results of anterior versus posterior pedicle screw instrumentation in Lenke5C AIS. Summary of Background Data. Anterior and posterior pedicle screw instrumentations are 2 established methods of correcting Lenke5C AIS. However, there are few reports that compare the 2 methods. Methods. Forty-six consecutive patients with Lenke5C AIS curves underwent selective lumbar or thoracolumbar fusion (1999-2005). Twenty-two patients had anterior surgery, and 24 patients had posterior surgery. Patients were evaluated at a minimum 2-year follow-up. Results. No complications occurred in either group. The number of levels involved in the major curve was similar for the anterior and posterior groups(5.5 vs. 5.7). Preoperative thoracic (24.13° ± 4.9° vs. 22.88° ± 5.14°) and lumbar/thoracolumbar (50.2° ± 7.52° vs. 52.2° ± 6.40°). Cobb values for the 2 groups were also similar. The percent correction of the lumbar curve was similar between the 2 groups at all stages of follow-up (56% vs. 57.7%), as was the percent of spontaneous correction of the unfused thoracic curve (25% vs. 27.2%). However, fusion levels were significantly shorter in the anterior group (mean, 5.09 vs. 6.13), and there were 8 patients (4 in the anterior group and 4 in the posterior group) whose thoracic curve became greater at the latest follow-up. The thoracolumbar/lumbar-thoracic Cobb ratio for these 8 patients was less than that for the other patients (1.34 vs. 2.43), and their curve flexibility was worse. Conclusion. Selective anterior and posterior screw instrumentation both achieved good surgical lumbar and subsequent spontaneous thoracic correction. There was no statistically significant difference between the 2 groups in lumbar correction or thoracic correction, but fusion levels were shorter in the anterior group. Patients with late thoracic curve decompensation had smaller thoracolumbar/lumbar-thoracic Cobb ratios and less preoperative flexibility than those who did not decompensate.

Adapted Simplified Chinese (Mainland) Version of Scoliosis Research Society-22 Questionnaire

Study Design. Validation study to define validity and reliability of an adapted and translated questionnaire. Objective. This study attempted to validate the traditional Chinese (Hong Kong) version of the modified Scoliosis Research Society (SRS) Outcomes Instrument, SRS-22, into simplified Chinese for use in mainland China. Summary of Background Data. Although a traditional Chinese (Hong Kong) adaptation of the SRS-22 has been previously validated, no culturally adapted, validated SRS-22 exists for use in mainland China. Methods. Adhering to International Quality of Life Assessment Project guidelines, the adapted traditional Chinese SRS-22 was translated into simplified Chinese while referencing the original English questionnaire. To examine the psychometric properties and clinical application of the adapted simplified Chinese SRS-22, a survey was conducted in a group of randomly selected 87 patients previously surgically treated at an outpatient clinic. Reliability assessment of the simplified Chinese version of the SRS-22 was determined by calculating Cronbach’s α and intraclass coefficient (ICC) values. Concurrent validity was evaluated by comparing SRS-22 domains with relevant domains of the simplified Short-Form-36 questionnaire; correlation was made using Pearson correlation coefficients. Results. Cronbach’s &agr;, applied to each of the 22 questions of the adapted SRS-22, revealed very satisfactory internal consistency (Cronbach’s &agr; = 0.80–0.89) for function/activity and pain, and good consistency (Cronbach’s &agr; = 0.50–0.79) for the remaining domains. The test/retest reproducibility was found to be good (ICC ≥0.40–0.75) in the function/activity domain, and excellent (ICC ≥0.75) in the remaining domains. In terms of concurrent validity, 3 domains had excellent correlation, while 10 had good correlation, and 21 had moderate correlation. Discussion. The authors report the validation of a simplified Chinese SRS-22 for use in mainland China, which is culturally relevant, reliable, repeatable, psychometrically sound, and suitable for immediate clinical use.

Anterior Fusion Technique for Multilevel Cervical Spondylotic Myelopathy: A Retrospective Analysis of Surgical Outcome of Patients with Different Number of Levels Fused

Objective The anterior approach for multilevel CSM has been developed and obtained favorable outcomes. However, the operation difficulty, invasiveness and operative risks increase when multi-level involved. This study was to assess surgical parameters, complications, clinical and radiological outcomes in the treatment of 2-, 3- and 4-level CSM. Methods A total of 248 patients with 2-, 3- or 4-level CSM who underwent anterior decompression and fusion procedures between October 2005 and June 2011 were divided into three groups, the 2-level group (106 patients), the 3-level group (98 patients) and the 4-level group (44 patients). The clinical and Radiographic outcomes including Japanese Orthopedic Association (JOA) score, Neck Disability Index (NDI) score, Odoms Scale, hospital stay, blood loss, operation time, fusion rate, cervical lordosis, cervical range of motion (ROM), and complications were compared. Results At a minimum of 2-year follow-up, no statistical differences in JOA score, NDI score, Odoms Scale, hospital stay, fusion rate and cervical lordosis were found among the 3 groups. However, the mean postoperative NDI score of the 4-level group was significantly higher than that in the other two groups (P<0.05), and in terms of postoperative total ROM, the 3-level group was superior to the 4-level group and inferior to 2-level group (P<0.05). The decrease rate of ROM in the 3-level group was significantly higher than that in the 2-level group, and lower than that in the 4-level group (P<0.05). Conclusions As the number of involved levels increased, surgical results become worse in terms of operative time, blood loss, NDI score, cervical ROM and complication rates postoperatively. An appropriate surgical procedure for multilevel CSM should be chosen according to comprehensive clinical evaluation before operation, thus reducing fusion and decompression levels if possible.

Unilateral versus bilateral pedicle screw instrumentation for single-level minimally invasive transforaminal lumbar interbody fusion

Minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) has become an increasingly popular method of lumbar arthrodesis. However, there are few published studies comparing the clinical outcomes between unilateral and bilateral instrumented MIS TLIF. Sixty-five patients with degenerative lumbar spine disease were enrolled in this study. Thirty-one patients were randomized to the unilateral group and 34 to the bilateral group. Recorded demographic data included sex, age, preoperative diagnosis, and degenerated segment. Operative time, blood loss, hospital stay length, complication rates, and fusion rates were also evaluated. The Oswestry Disability Index (ODI) score and Visual Analog Scale (VAS) pain score data were obtained. All patients were asked to follow-up at 3 and 6 months after surgery, and once every 6 months thereafter. The mean follow-up was 26.6 months (range 18-36 months). The two groups were similar in sex, age, preoperative diagnosis, and operated level. The unilateral group had significantly shorter operative time, lower blood loss, and shorter hospital time than the bilateral group. The average postoperative ODI and VAS scores improved significantly in each group. No significant differences were found between the two groups in relation to ODI and VAS. All patients showed evidence of fusion at 12 months postoperatively. The total fusion rate, screw failure, and general complication rate were not significantly different. Results showed that single-level MIS TLIF with unilateral pedicle screw fixation would be sufficient in the management of preoperatively stable patients with lumbar degenerative disease. It seems that MIS TLIF with unilateral pedicle screw instrumentation is a better choice for single-level degenerative lumbar spine disease.

Diffusion Tensor Imaging Studies of Cervical Spondylotic Myelopathy: A Systemic Review and Meta-Analysis

A meta-analysis was conducted to assess alterations in measures of diffusion tensor imaging (DTI) in the patients of cervical spondylotic myelopathy (CSM), exploring the potential role of DTI as a diagnosis biomarker. A systematic search of all related studies written in English was conducted using PubMed, Web of Science, EMBASE, CINAHL, and Cochrane comparing CSM patients with healthy controls. Key details for each study regarding participants, imaging techniques, and results were extracted. DTI measurements, such as fractional anisotropy (FA), apparent diffusion coefficient (ADC), and mean diffusivity (MD) were pooled to calculate the effect size (ES) by fixed or random effects meta-analysis. 14 studies involving 479 CSM patients and 278 controls were identified. Meta-analysis of the most compressed levels (MCL) of CSM patients demonstrated that FA was significantly reduced (ES -1.52, 95% CI -1.87 to -1.16, P < 0.001) and ADC was significantly increased (ES 1.09, 95% CI 0.89 to 1.28, P < 0.001). In addition, a notable ES was found for lowered FA at C2-C3 for CSM vs. controls (ES -0.83, 95% CI -1.09 to -0.570, P < 0.001). Meta-regression analysis revealed that male ratio of CSM patients had a significant effect on reduction of FA at MCL (P = 0.03). The meta-analysis of DTI studies of CSM patients clearly demonstrated a significant FA reduction and ADC increase compared with healthy subjects. This result supports the use of DTI parameters in differentiating CSM patients from health subjects. Future researches are required to investigate the diagnosis performance of DTI in cervical spondylotic myelopathy.

Radiation exposure to surgeon in minimally invasive transforaminal lumbar interbody fusion with novel spinal locators.

Study Design: A prospective study. Objective: To further investigate the implication of our surface locator and intradermal locator to reduce the radiation exposure to surgeons in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) surgery. Summary of Background Data: Our previous studies published in the journal have introduced our novel spinal locators effectively minimizing fluoroscopic time during minimally invasive spinal surgery. Methods: Twenty patients underwent MIS-TLIF surgery with G-arm fluoroscopy from January 2013 to June 2013. There were 10 patients in group A who underwent standard MIS-TLIF using our spinal locators, and the other 10 in group B underwent conventional MIS-TLIF without spinal locators. The radiation dosages to the arm, the finger, the whole body, thyroid gland, gonad gland, and the eye of the surgeon were measured by thermoluminescence badges for both groups. Results: All 20 patients (9 male, 11 female), aged from 48 to 77 years old, successfully underwent the surgery. The operation time was 171.20±10.28 minutes for group A and 189.80±11.99 minutes for group B. The fluoroscopy time was 49.60±7.32 seconds for group A and 68.40±7.62 seconds for group B, hence a reduction of 27.49% was observed. There was no correlation between operation time and exposure time for group A or group B. The radiation reduction was 35.28% for the arm, 17.95% for the finger, 45.23% for the whole body, 53.62% for the thyroid gland (protected), 52.44% for the thyroid gland (unprotected), 44% for gonad gland (protected), 36.42% for the gonad gland (unprotected), 59.42% for the eye (protected), and 59.70% for the eye (unprotected). Conclusion: The study indicated that radiation exposure to the surgeon would be effectively reduced in MIS-TLIF using our surface locator and intradermal locator, and it could be another practical choice for radiation-minimizing strategy.

Preoperative localization methods for minimally invasive surgery in lumbar spine: comparisons between a novel method and conventional methods.

Study Design: This is a prospective single-center nonrandomized control clinical study involving 220 patients who underwent the novel localization method or conventional methods preoperatively in a minimally invasive surgery in lumbar spine. Objective: To introduce a novel preoperative locator designed by the authors for a minimally invasive surgery in lumbar spine and to compare the novel localization method with conventional methods in mean localization time and the mean number of C-arm fluoroscopy use preoperatively. Summary of Background Data: Conventional localization methods for minimally invasive surgery in lumbar spine are associated with more fluoroscopy time and radiation exposure. We describe a novel preoperative locator to help localize spinal anatomic landmarks, minimize preoperative localization time, and decrease radiation exposure. There have been no prospective clinical reports published on the comparison of the novel localization method with conventional methods. Methods: A total of 220 patients, 86 (39.1%) men and 134 (60.9%) women with an average age of 53.8±16.4 years were prospectively evaluated. We divided all patients into 2 groups. Group A: the first 100 patients who received the conventional preoperative localization methods (the palpation method and the Kirschner wire method). Group B: the remaining 120 patients who localized the spinal levels with the help of the novel locator before surgery. The localization time and the number of C-arm fluoroscopy use preoperatively were recorded. Results: The mean localization time of patients in groups A and B were 7.37±3.77 and 3.85±2.45 minutes, respectively. The mean number of preoperative C-arm fluoroscopy use in groups A and B were 2.29 and 1.29. There was significant difference in mean localization time and the mean number of C-arm fluoroscopy use between groups A and B (P<0.05). There was no incidence of wrong-level surgery in both groups. Conclusions: The novel preoperative locator is a simple and practical device that can help to minimize preoperative localization time and decrease radiation exposure.

Using side-bending radiographs to determine the distal fusion level in patients with single thoracic idiopathic scoliosis undergoing posterior correction with pedicle screws.

Study Design Prospective. Objectives To evaluate a strategy to determine the distal fusion level in posterior pedicle screw correction of single thoracic idiopathic scoliosis. Summary of Background Data No standard method for selecting the lowest instrumented vertebra (LIV) for the correction of thoracic adolescent idiopathic scoliosis with posterior all-pedicle screw instrumentations exists. Methods Thirty-eight patients with single right thoracic (Lenke 1A) adolescent idiopathic scoliosis undergoing posterior pedicle screw fixation were studied. The LIV was determined using guidelines based on preoperative side-bending radiographs. In brief, (1) the whole thoracic Cobb curve should be included in the fusion mass, and the LIV should not be superior to the lower-end vertebra of the Cobb measurement. (2) On the right side-bending radiographs, the LIV should be derotated to neutral in skeletally immature (Risser 0 to 3) patients and the disc immediately below the LIV must open on the left side by at least 5 degrees. (3) On the left side-bending radiographs, the disc immediately below the LIV must be open on the right side by at least 0 degree. The first segment meeting the criteria when proceeding from the lower-end vertebra caudally is chosen as the LIV. Outcomes were based on the standing radiographs. Results Minimum follow-up was 2 years. The mean preoperative thoracic curve was 48.4±9.2 degrees and 12.6±6.1 degrees at final follow-up, resulting in a mean correction of 74.7%±8.5%. The mean preoperative compensatory lumbar curve of 23.7±7.5 degrees was 6.3±4.8 degrees at final follow-up. A change in lumbar lordosis from −41.2±11.9 degrees preoperatively to −38.2±9.9 degrees at final follow-up occurred. All patients achieved coronal balance and no decompensation or adding-on phenomenon was observed. Compared with the recommended fusion end by the Harrington stable zone method, 86.9% patients were saved 1 or more motion segment. Conclusions The method described was effective in obtaining satisfactory curve correction, adequate trunk balance, and preservation of motion segments.

Significant Improvement of Puncture Accuracy and Fluoroscopy Reduction in Percutaneous Transforaminal Endoscopic Discectomy With Novel Lumbar Location System: Preliminary Report of Prospective Hello Study

AbstractProspective nonrandomized control study.The study aimed to investigate the implication of the HEs Lumbar LOcation (HELLO) system in improving the puncture accuracy and reducing fluoroscopy in percutaneous transforaminal endoscopic discectomy (PTED).Percutaneous transforaminal endoscopic discectomy is one of the most popular minimally invasive spine surgeries that heavily depend on repeated fluoroscopy. Increased fluoroscopy will induce higher radiation exposure to surgeons and patients. Accurate puncture in PTED can be achieved by accurate preoperative location and definite trajectory.The HELLO system mainly consists of self-made surface locator and puncture-assisted device. The surface locator was used to identify the exact puncture target and the puncture-assisted device was used to optimize the puncture trajectory. Patients who had single L4/5 or L5/S1 lumbar intervertebral disc herniation and underwent PTED were included the study. Patients receiving the HELLO system were assigned in Group A, and those taking conventional method were assigned in Group B. Study primary endpoint was puncture times and fluoroscopic time, and the secondary endpoint was location time and operation time.A total of 62 patients who received PTED were included in this study. The average age was 45.35 ± 8.70 years in Group A and 46.61 ± 7.84 years in Group B (P = 0.552). There were no significant differences in gender, body mass index, conservative time, and surgical segment between the 2 groups (P > 0.05). The puncture time(s) were 1.19 ± 0.48 in Group A and 6.03 ± 1.87 in Group B (P < 0.001). The fluoroscopic times were 14.03 ± 2.54 in Group A and 25.19 ± 4.28 in Group B (P < 0.001). The preoperative location time was 4.67 ± 1.41 minutes in Group A and 6.98 ± 0.94 minutes in Group B (P < 0.001). The operation time was 79.42 ± 10.15 minutes in Group A and 89.65 ± 14.06 minutes in Group B (P = 0.002). The hospital stay was 2.77 ± 0.95 days in Group A and 2.87 ± 1.02 days in Group B (P = 0.702). There were no significant differences in the complication rate between the 2 groups (P = 0.386).The highlight of HELLO system is accurate preoperative location and definite trajectory. This preliminary report indicated that the HELLO system significantly improves the puncture accuracy of PTED and reduces the fluoroscopic time, preoperative location time, as well as operation time. (ChiCTR-ICR-15006730)

Radiographic Analysis of One-level Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF) With Unilateral Pedicle Screw Fixation for Lumbar Degenerative Diseases.

Study Design: A prospective randomized study was conducted. Objective: The purpose of this study was to assess the radiographic outcomes of one-level minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) with unilateral pedicle screw instrumentation for degenerative lumbar spine disease. Summary of Background Data: MI-TLIF has become an increasingly popular method of lumbar arthrodesis. Recent technological advances in spinal instrumentation have culminated in the development of MI-TLIF with unilateral pedicle screw fixation. However, there are few published studies on radiographic outcomes of the MI-TLIF with unilateral pedicle screw fixation. Methods: A total of 65 patients with one-level degenerative lumbar spine disease were enrolled in this study. Patients were randomized into the unilateral or bilateral fixation group based on a computer-generated number list. Thirty-one patients (17 men and 14 women; average age, 57.3 y) were randomized to the unilateral group (group A) and 34 patients (16 men and 18 women; average age, 58.9 y) to the bilateral group (group B). All patients underwent minimally invasive decompression, interbody fusion, and pedicle screw fixation with the assistance of microscopic tubular retractor system (METRx-MD) and Sextant system. All patients were asked to follow-up at 3, 6, and thereafter once every 6 months after surgery. The visual analog scale (VAS), Oswestry disability index (ODI), and modified Prolo (mProlo) scores were obtained for all patients 24 hours before the operation and at each follow-up visit. The whole lumbar lordosis (WL), the segmental lordosis (SL), fusion level disk space angle, lumbar scoliosis angle, and segmental scoliosis angle were determined before and after surgery on standard x-rays. The disk height index (DI) and the lumber curvature index (LI) were also evaluated. Results: The mean follow-up was 26.6 months, with a range of 18–36 months. All patients showed evidence of fusion at 12 months postoperatively. Statistically, there was no significant difference between the 2 groups in terms of demographic data. The average postoperative VAS, ODI, and mProlo scores improved significantly in each group. No significant differences were found between the 2 groups in relation to VAS, ODI, and mProlo scores at each follow-up time point. There were no significant differences between the 2 groups in relation to WL, SL, disk space angle, lumbar scoliosis angle, segmental scoliosis angle, DI, and LI. There was also no difference between postoperative different follow-up visits in terms of these radiographic parameters in both groups. There was a positive linear correlation between the LI and WL in both groups. Conclusions: One-level unilateral pedicle screw instrumented MI-TLIF provided similar radiologic and clinical outcomes to bilateral pedicle screw instrumented MI-TLIF. This study showed that MIS-TLIF with unilateral pedicle screw fixation would be sufficient in the management of preoperatively stable patients with lumbar degenerative disease.