Shobu R

Changes of plasma insulin glucagon and somatostatin in portal blood and morphological changes of islets of Langerhans after hepatectomy in dogs.

SummaryHybrid adult male dogs were laparotomized before, one week after and one month after 40% hepatectomy. At the same time, an intravenous glucose tolerance test was done (IV-GTT) and pancreatic tissues were removed and examined by PAP staining.The following results were obtained:Carbohydrate metabolism was disturbed and plasma insulin levels were low one week after surgery, but B-cell granulations was at the preoperative level. It seemed that hypersomatostatinemia suppressed insulin release from B cells.Carbohydrate metabolism was restored to normal and the plasma insulin response was increased one month after surgery.Islets of Langerhans cells were hypertrophic and increased after surgery, particularly D cells.

Hepatocellular carcinoma with extrahepatic growth: a case report and review of the Japanese literature

SummaryA case of extrahepatically growing hepatocellular carcinoma is reported, and the Japanese literature is reviewed. A 42-year-old man was admitted to our hospital on December 27,1985 complaining of epigastralgia and nausea. Ultrasonography and computerized tomography showed a large tumor in the right hepatic lobe. This Was removed surgically and examined histologically.