Shoichiro Minami

Dermal Nerve Sheath Myxoma

A case of dermal nerve sheath myxoma on the left palm of 26‐year‐old Japanese man is presented. We examined this tumor by light and electron microscopies. On light microscopic examination, this tumor was characterized by a multilobulated myxoid tumor composed of stellate cells in an abundant mucous matrix. This histological feature resembled previously reported cases of dermal nerve sheath myxoma. On electron microscopic examination, the findings of these tumor cells were similar to those of the perineurial cells. These microscopical examinations have provided evidence for an origin from perineurial cells rather than Schwann cells.

Non‐anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: A case report and review of reported cases

Hidradenoma papilliferum is a benign tumor that usually occurs in the female anogenital region. We present a 52‐year‐old male with a non‐anogenital (ectopic) hidradenoma papilliferum on his face. He had had a subcutaneous tumor on his right eyebrow for 30 years. The histological findings included variously shaped cystic and tubular structures in the tumor. The lumina were surrounded by a double layer of cells and showed active decapitation secretion. The lesion contained sebaceous differentiation, which has not been previously documented in the histopathology of hidradenoma papilliferum. We review the published work of non‐anogenital (ectopic) hidradenoma papilliferum tumors on the head and neck.

Cutaneous malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) arising in a chronic scalp ulcer of a patient with non‐bullous congenital ichthyosiform erythroderma

Editor An increased incidence of squamous cell carcinoma (SCC) has been pointed out in patients with lamellar ichthyosis or nonbullous congenital ichthyosiform erythroderma (NBCIE).1,2 However, those ichthyoses accompanied by cutaneous sarcomas have not previously been reported. We herein present a case of a cutaneous malignant fibrous histiocytoma (MFH) arising from a chronic scalp ulcer of a patient with NBCIE. A 38-year-old woman presented in July 2004. She had generalized erythemas with severe ivory-coloured thick scales after birth (Fig. 1a). Her toes and fingers were contracted with severe hyperkeratosis and all nails were thickened. A family history of the same disease was absent in her pedigree. At the age of 25, SCC developed on her left parietal region. The tumour was completely resected, and the defect was covered with a free skin graft from her left axilla. After the treatment, a localized ulcer appeared on the left temporal region of her scalp. The ulcer gradually enlarged with reddish granulations. In September 2005, an elevated nodule appeared on the temporal region of the ulcer and rapidly enlarged up to 4 cm in its major axis in 1 month (Fig. 1b). Her ichthyosiform skin showed acanthosis with hypergranulosis and severe hyperkeratosis. Involucrin was localized on the cell membrane of the middle to upper layers, and that transglutaminase 1 was on those of the upper layers of the epidermis. In situ transglutaminase assay revealed the incorporation of the substrate cadaverine into the cell periphery of the granular layers (Fig. 1c). The tumour of her scalp was composed of atypical fibroblastic spindle cells forming storiform or fascicular patterns (Fig. 1d) and numerous pleomorphic plump histiocytic cells with mitotic figures involving the dermis. The tumour cells were positive for vimentin, weakly positive for α1-antitrypsin, α1antichymotrypsin, and partly positive for α-smooth muscle actin, but negative for desmin, S-100, Factor VIII, CD68, CD31 and CD34. From those findings, an NBCIE accompanied by MFH was thus diagnosed. The tumour was completely resected followed by radiation therapy of a total of 66 Gy. No local recurrence or metastasis of the tumour has been detected for 2 years. The MFH of the present case originated from ulcerated skin and involves the dermis and only a part of the subcutaneous tissue. Dermatofibrosarcoma protuberans, pleomorphic leiomyoma, malignant melanoma and spindle cell carcinoma were excluded by histology and by immunohistochemistry, but the rapid growth of the tumour centred in the dermis might be suggestive of an atypical fibroxanthoma (AFX). However, our case is

Flow Cytometric Analysis of Murine Splenic Cells after DNFB Painting on Langerhans Cell Deficient Skin

One week after a single painting of 50 μ1 of 0.5% DNFB in acetone‐olive oil on the tail skin of C3H mice, the spleens were removed from the animals. A single cell suspension was prepared from the spleens, and flow cytometric analysis was performed for L3T4 and Lyt2 positive cells, as well as for the IJk expression of the Lyt2+ cells.

Statistical Analysis of Basal Cell Carcinoma

1985年から2002年までの18年間に, 当科において病理組織学的に基底細胞癌と診断した207症例, 247病変について検討した。男性123例, 女性84例で男性にやや多いが, 18年間で増加, 減少傾向は認めなかった。部位別では, 顔面が70.4%と最も多く, 鼻部, 眼瞼部, 頬部で75%を占めていた。WHO分類に準じて病理組織学的分類の再検討を行ったが, nodular typeが37.7%と最も多く, 顔面だけでみるとその比率は44.9%に達した。WHO分類に含まれていないmixed typeが28.3%存在し, これらの取り扱いを含め, 病理組織学的分類の確立が重要であると思われる。

Therapeutic experience of basal cell epithelioma carried out in accordance with a fresh organization method of Mohs.

64歳, 女性の鼻背部基底細胞上皮腫に対し, Mohsの新鮮組織法 (Mohs micrographicsurgery fresh-tissue technique) に準じた方法で摘出し, 正中前額皮弁により再建した症例を経験した。Mohsの新鮮組織法は, 視診・触診にて, 術前に腫瘍の切除範囲が決定しにくいような基底細胞上皮腫には, 良い適応と思われた。