Shrikant R. Bharadwaj
L V Prasad Eye Institute
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Publication
Featured researches published by Shrikant R. Bharadwaj.
Journal of The Optical Society of America A-optics Image Science and Vision | 2002
Michael A. Webster; Shernaaz M. Webster; Shrikant R. Bharadwaj; Richa Verma; Jaikishan Jaikumar; Gitanjali Madan; E. Vaithilingham
Basic color categories are thought to share a common pattern across linguistic groups, yet the focal colors defining those categories can vary substantially within any single group. We asked whether focal colors can also differ systematically across different groups of individuals living in potentially different color environments, by measuring focal and unique hues for observers in India and the United States. Differences between groups were generally small relative to the within-group variations, consistent with a strong common basis for color naming across diverse contexts. However, for most hues the average settings differed significantly across subpopulations. These differences persisted across testing conditions and thus probably reflect longer-term contextual influences on color appearance judgments. They suggest that while color categories may be qualitatively similar, precisely how the hue spectrum is parsed may differ quantitatively across different populations of observers. Both the between-group and the within-group differences are inconsistent with the differences predicted by common peripheral sources of variation in color vision (e.g., in lens or macular pigment) and may reflect an influence of environmental or cultural differences in focal color choices.
Vision Research | 2005
Shrikant R. Bharadwaj; Clifton M. Schor
Position and velocity of accommodation are known to increase with stimulus magnitude, however, little is known about acceleration properties. We investigated three acceleration properties: peak acceleration, time-to-peak acceleration and total duration of acceleration to step changes in defocus. Peak velocity and total duration of acceleration increased with response magnitude. Peak acceleration and time-to-peak acceleration remained independent of response magnitude. Independent first-order and second-order dynamic components of accommodation demonstrate that neural control of accommodation has an initial open-loop component that is independent of response magnitude and a closed-loop component that increases with response magnitude.
Vision Research | 2006
Shrikant R. Bharadwaj; Clifton M. Schor
Velocity and acceleration characteristics provide valuable information about dynamic control of accommodation. We investigated velocity and acceleration of disaccommodation (near-far focusing) from three starting positions. Peak velocity and peak acceleration of disaccommodation increased with the proximity of starting position however for a given starting position they were invariant of response magnitude. These results suggest that all disaccommodation responses are initiated towards a constant primary destination and are switched mid-flight to attain the desired final position. Large discrepancies between the primary destination and desired final position appear to produce overshoots and oscillations of small responses from proximal starting positions.
Vision Research | 2005
Clifton M. Schor; Shrikant R. Bharadwaj
We have developed a dynamic model of accommodation that combines independent phasic-velocity and tonic-position neural signals to control position, velocity and acceleration properties of accommodative step responses. Phasic and tonic signals were obtained from neural integration of a fixed-height acceleration-pulse and variable-height velocity-step respectively to control independent acceleration and velocity properties of the step response. Duration and amplitude of the acceleration-pulse are increased with age to compensate for age-related increases of visco-elastic properties of the lens to maintain youthful velocity. The model illustrates a neural control strategy that is similar to the classical neural control model of step changes by the saccadic and vergence systems.
Vision Research | 2006
Clifton M. Schor; Shrikant R. Bharadwaj
Dynamic properties and control strategies of step responses by accommodation and disaccommodation differ from one another. Peak velocity of accommodation increases with response magnitude, while peak velocity and peak acceleration of disaccommodation increase with starting position. These dynamic properties can be modeled as control strategies that use independent acceleration-pulse and velocity-step components that are integrated respectively into phasic-velocity signals that control movement and tonic-position signals that control magnitude. Accommodation is initiated toward its final destination by an acceleration-pulse whose width increases with response magnitude to increase peak velocity. Disaccommodation is initiated toward a default destination (the far point) by an acceleration-pulse whose height increases with dioptric distance of the starting position to increase peak velocity and peak acceleration. Both responses are completed and maintained by tonic-position signals whose amplitudes are proportional to the final destination. Mismatched amplitudes of phasic-velocity and tonic-position signals in disaccommodation produce unstable step responses.
Journal of The Optical Society of America A-optics Image Science and Vision | 2013
Shrikant R. Bharadwaj; N. Geetha Sravani; Julie-Anne Little; Asa Narasaiah; Vivian Wong; Rachel Woodburn; T. Rowan Candy
Refraction estimates from eccentric infrared (IR) photorefraction depend critically on the calibration of luminance slopes in the pupil. While the intersubject variability of this calibration has been estimated, there is no systematic evaluation of its intrasubject variability. This study determined the within subject inter- and intra-session repeatability of this calibration factor and the optimum range of lenses needed to derive this value. Relative calibrations for the MCS PowerRefractor and a customized photorefractor were estimated twice within one session or across two sessions by placing trial lenses before one eye covered with an IR transmitting filter. The data were subsequently resampled with various lens combinations to determine the impact of lens power range on the calibration estimates. Mean (±1.96 SD) calibration slopes were 0.99±0.39 for North Americans with the MCS PowerRefractor (relative to its built-in value) and 0.65±0.25 Ls/D and 0.40±0.09 Ls/D for Indians and North Americans with the custom photorefractor, respectively. The ±95% limits of agreement of intrasubject variability ranged from ±0.39 to ±0.56 for the MCS PowerRefractor and ±0.03 Ls/D to ±0.04 Ls/D for the custom photorefractor. The mean differences within and across sessions were not significantly different from zero (p>0.38 for all). The combined intersubject and intrasubject variability of calibration is therefore about ±40% of the mean value, implying that significant errors in individual refraction/accommodation estimates may arise if a group-average calibration is used. Protocols containing both plus and minus lenses had calibration slopes closest to the gold-standard protocol, suggesting that they may provide the best estimate of the calibration factor compared to those containing either plus or minus lenses.
Investigative Ophthalmology & Visual Science | 2011
Shrikant R. Bharadwaj; T. Rowan Candy
PURPOSE Clear and single binocular vision, a prerequisite for normal human visual development, is achieved through accommodation and vergence. Anisometropia is associated with abnormal visual development, but its impact on accommodation and vergence, and therefore on the individuals visual experience, is not known. This study determined the impact of transiently induced anisometropia on accommodative and vergence performance of the typically developing human visual system. METHODS One hundred eighteen subjects (age range, 2.9 months to 41.1 years) watched a cartoon movie that moved between 80 and 33 cm under six different viewing conditions: binocular and monocular, and with ±2 diopters (D) and ±4 D of lens-induced anisometropia. Twenty-one subjects (age range, 3.1 months to 12.1 years) also watched the movie with 11% induced aniseikonia. Accommodation and vergence were recorded in both eyes using a videoretinoscope (25 Hz). RESULTS The main effect of viewing condition was statistically significant for both accommodation and vergence (both P < 0.001), with monocular accommodative and vergence gains statistically significantly smaller than the binocular and four induced anisometropia conditions (P < 0.001 for both accommodation and vergence). The main effect of age approached significance for accommodation (P = 0.06) and was not significant for vergence (P = 0.32). Accommodative and vergence gains with induced aniseikonia were not statistically significantly different from the binocular condition (both P > 0.5). CONCLUSIONS Accommodative and vergence gains of the typically developing visual system deteriorated marginally (accommodation more than vergence) with transiently induced anisometropia (up to ±4 D) and did not deteriorate significantly with induced aniseikonia of 11%. Some binocular cues remained with ±4 D of induced anisometropia and 11% induced aniseikonia, as indicated by the accommodative and vergence gains being higher than in monocular viewing.
Optometry and Vision Science | 2013
Archana Singh; Veerendranath Pesala; Prashant Garg; Shrikant R. Bharadwaj
Purpose. The end point of astigmatic correction after cataract surgery will depend on how uncorrected astigmatism impacts distance and near vision of pseudophakic eyes. This study determined the impact of induced astigmatism and pupil size on the distance and near acuity of otherwise emmetropic pseudophakic eyes implanted with monofocal intraocular lenses. Methods. Monocular high-contrast distance (4 m) and near (40 cm) logMAR acuity was determined in 15 subjects (mean ± 1 SD, 57.9 ± 9.0 years) without astigmatism and with 2.5 diopters (D) myopic to 2.0 D hyperopic astigmatic lenses induced in 0.5-D steps at 0-, 45-, 90-, and 135-degree axes. This experiment was repeated for the same range of induced astigmatism with 1.5-, 3-, and 6-mm artificial pupil diameters placed before one eye of 10 subjects dilated with 10% phenylephrine HCl. Results. Distance acuity deteriorated with astigmatism for all axes tested (p < 0.01). Near acuity deteriorated with hyperopic astigmatism (p < 0.1), whereas it improved with up to 1 D of myopic astigmatism before saturating for all axes tested (p < 0.01). Distance and near acuity improved with a reduction in pupil diameter (p < 0.01). The change in distance and near acuity with induced astigmatism was smaller for 1.5-mm than for 3-mm and 6-mm pupil diameters (p < 0.01). Conclusions. Partial restoration of near acuity with uncorrected myopic astigmatism comes with a proportional loss of distance acuity in pseudophakic eyes. Uncorrected myopic astigmatism more than 1 D results in a large loss of distance acuity at no additional benefit to near acuity. Both distance and near acuities with and without astigmatism are benefited with a reduction in pupil diameter. Uncorrected hyperopic astigmatism results in deterioration of both distance and near acuities of pseudophakic eyes.
Journal of Vision | 2011
Shrikant R. Bharadwaj; Jingyun Wang; T. Rowan Candy
Pupil responses of adults to near visual demands are well characterized but those of typically developing infants and children are not. This study determined the following pupil characteristics of infants, children and adults using a PowerRefractor (25 Hz): i) binocular and monocular responses to a cartoon movie that ramped between 80 and 33 cm (20 infants, 20 2-4-yr-olds and 20 adults participated) ii) binocular and monocular response threshold for 0.1 Hz sinusoidal stimuli of 0.25 D, 0.5 D or 0.75 D amplitude (33 infants and 8 adults participated) iii) steady-state stability of pupil responses at 80 cms (8 infants and 8 adults participated). The change in pupil diameter with viewing distance (Δpd) was significantly smaller in infants and 2-4-yr-olds than in adults (p < 0.001) and significantly smaller under monocular than binocular conditions (p<0.001). The 0.75 D sinusoidal stimulus elicited a significant binocular pupillary response in infants and a significant binocular and monocular pupillary response in adults. Steady-state pupillary fluctuations were similar in infants and adults (p = 0.25). The results suggest that the contribution of pupil size to changes in retinal image quality when tracking slow moving objects may be smaller during development than in adulthood. Smaller monocular Δpd reflects the importance of binocular cues in driving near-pupillary responses.
Vision Research | 2006
Shrikant R. Bharadwaj; Clifton M. Schor
Peak velocity and peak acceleration of disaccommodation step responses remain invariant of response magnitude for a constant starting position and they increase linearly with proximity of starting position. This suggests that disaccommodation response is initiated towards an initial (default) destination and is switched mid-flight to attain the desired final destination. The dioptric location of initial destination was estimated from the x-intercept of regression of peak velocity on response starting position. The x-intercept correlated well with subjects cycloplegic refractive state and poorly with their dark focus of accommodation. Altering the dark focus by inducing fatigue in the accommodative system did not alter the x-intercept. These observations suggest that cycloplegic refractive state is a good behavioral correlate of initial destination of disaccommodation step responses.