Shu Shu Yang | Researchain

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Tetrahedron Letters | 1982

Synthesis of fluorodeoxyscylloinositol and phosphatidylfluorodeoxyscylloinositol

Shu Shu Yang; Thomas R. Beattie; Tsung-Ying Shen

Abstract Synthesis of 1-fluoro-1-deoxyscylloinositol and 2-fluoro-2-deoxy-1-phosphatidylscylloinositol from myoinositol is described.

Synthetic Communications | 1988

Synthesis of 2-C-Fluoromethyl-Myo-Inositol

Shu Shu Yang; Ji Mei Min; Thomas R. Beattie

Abstract Synthesis of 2-C-fluoromethyl-myo-inositol from DL-l-O-benzyl-2-oxiranyl-3, 4, 5, 6-tetra-O-benzyl-myo-inositol is described.

Tetrahedron Letters | 1991

Synthesis of δ-lactone, oxetane and azetidinone analogs from the naturally occurring β-lactone L-659,699. The preparation of a novel HMG CoA synthase inhibitor.

Kathryn L. Thompson; Michael N. Chang; Yuan-Ching P. Chiang; Shu Shu Yang; John C. Chabala; Byron H. Arison; Michael D. Greenspan; Darlene P. Hanf; Joel B. Yudkovitz

Abstract A series of δ-lactone ( 1 and 2 ), oxetane ( 3 ) and azetidinone ( 4 and 5 ) analogs were prepared from the HMG CoA synthase inhibitor L-659,699 ((E,E)-11-[3′R-(hydroxymethyl)-4′-oxo-2′R-oxetanyl]-3,5,7R- trimethyl-2,4-undecadienoic acid 1,2 ), which maintained the trans relationship of the ring side chains. The N-tosyl azetidinone analog represents the first reported member of a new series of non β-lactone HMG CoA synthase inhibitors.

Archive | 1989