Shun Satoh

Laparoscope-Assisted Versus Conventional Restorative Proctocolectomy with Rectal Mucosectomy

Abstract To assess the advantages of a laparoscope-assisted proctocolectomy with ileal J-pouch anal anastomosis compared with conventional procedures, we retrospectively analyzed the results of the two procedures as follows: Eleven patients including five patients with familial adenomatous polyposis (FAP) and six with ulcerative colitis (UC) underwent a laparoscope-assisted proctocolectomy and hand-sewn ileal J-pouch anal anastomosis at our department from June 1997 to November 1999. This laparoscope-assisted colectomy (LAC) group was then compared with a group of 13 patients who had undergone conventional ileal pouch anal anastomosis using a standard laparotomy from 1986 to 1997. The median operative time of the LAC group was 8 h 23 min, which was 81 min longer than that of the standard colectomy (SC) group. The number of days during which eating was prohibited were similar in the two groups but the median postoperative hospital stay was significantly shorter in the LAC group (24.1 days). In the LAC group, the small incisions showed better cosmetic results and there was also a remarkable reduction in the degree of postoperative pain. In conclusion, a laparoscope-assisted proctocolectomy with ileal J-pouch anal anastomosis can be employed widely in patients with FAP and also in selected patients with UC.

The antiarrhythmic effect of flecainide on halothane-epinephrine induced arrhythmias in dogs.

The antiarrhythmic effect of flecainide acetate (FCN), a newly developed class I antiarrhythmic drug, was evaluated on epinephrine (E)-halothane induced arrhythmias in dogs. The arrhythmogenic dose of E (ADE) under 1%of halothane was significantly increased from 0.71±0.08 to 1.08±0.11 and 1.84±0.23 μ·kg−1·min−1 by the administration of 2 and 4 mg·kg−1 of FCN, respectively. The arrhythmias induced by ADE in the absence of FCN were stopped by 1.78 ±0.29 mg·kg−1 of FeN in bolus injections. These results suggest that FCN can be used for the treatment of arrhythmias that E contributes to under halothane anesthesia.

Identification of genes selectively expressed in small or large intestinal epithelial cells (EC) in mice

However, this increase did not reach statistical significance (P=O,O6 and 0,09) due to a wide range of the bursting pressure data in both groups. Conclusion:. Administration of the immunosuppressive agent MMF again impairs healing and mechanical stability of colon anastomosis in rats during the early postoperative period, which confirms our previous findings. The growth factor IGF-I tends to neutralize this negative MMF-effect on anastomotic healing with findings of a very similar stability of anastomoses as observed in control (vehicle) animals. These preliminary findings may provide insight into new therapeutic approaches to ensure anastomotic healing in immunocompromised hosts as patient after transplantation or IBD patients on an immunosuppressive regimen.