Simon Everitt
Vertex Pharmaceuticals
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Publication
Featured researches published by Simon Everitt.
Bioorganic & Medicinal Chemistry Letters | 2009
David Bebbington; Hayley Binch; Jean-Damien Charrier; Simon Everitt; Damien Fraysse; Julian Golec; David Kay; Ronald Knegtel; Chau Mak; Francesca Mazzei; Andrew Miller; Michael Mortimore; Michael O’Donnell; Sanjay Patel; Francoise Pierard; Joanne Pinder; John Pollard; Sharn Ramaya; Daniel Robinson; Alistair Rutherford; John Studley; James Westcott
The identification of a novel series of Aurora kinase inhibitors and exploitation of their SAR is described. Replacement of the initial quinazoline core with a pyrimidine scaffold and modification of substituents led to a series of very potent inhibitors of cellular proliferation. MK-0457 (VX-680) has been assessed in Phase II clinical trials in patients with treatment-refractory chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) containing the T315I mutation.
Archive | 2005
Francesco Salituro; Luc J. Farmer; Randy S. Bethiel; Edmund Harrington; Jeremy Green; John J. Court; Jon H. Come; David J. Lauffer; Alex Aronov; Hayley Binch; Dean Boyall; Jean-Damien Charrier; Simon Everitt; Damien Fraysse; Michael Mortimore; Francoise Pierard; Daniel Robinson; Jian Wang; Joanne Pinder; Tiansheng Wang; Albert Pierce
Archive | 2006
Hayley Binch; Michael Mortimore; Damien Fraysse; Christopher John Davis; Michael O'donnell; Simon Everitt; Daniel Robinson; Joanne Pinder; Andrew Miller
Archive | 2003
David Bebbington; Hayley Binch; Jean-Damien Charrier; Simon Everitt; Julian Golec; David Kay; Ronald Knegtel; Andrew Miller; Francoise Pierard
Archive | 2003
David Bebbington; Hayley Binch; Jean-Damien Charrier; Simon Everitt; Julian Golec; David Kay; Ronald Knegtel; Andrew Miller; Francoise Pierard
Archive | 2003
David Bebbington; Hayley Binch; Jean-Damien Charrier; Simon Everitt; Julian Golec; David Kay; Ronald Knegtel; Andrew Miller; Francoise Pierard
Archive | 2007
Michael Mortimore; Stephen Young; Simon Everitt; Ronald Knegtel; Joanne Pinder; Alistair Rutherford; Steven Durrant; Guy Brenchley; Jean Damien Charrier; Michael O'donnell
Archive | 2006
Hayley Binch; Simon Everitt; Michael Mortimore; Daniel Robinson; Dean Stamos
Archive | 2004
Hayley Binch; Simon Everitt; Francesca Mazzei; Daniel Robinson
Archive | 2013
Dean Boyall; Christopher John Davis; James Dodd; Simon Everitt; Andrew Miller; Peter Weber; James Westcott; Stephen Young; Luca Settimo
