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Dive into the research topics where Simona Sputore is active.

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Featured researches published by Simona Sputore.


Bioorganic & Medicinal Chemistry | 2010

Novel analogues of Istaroxime, a potent inhibitor of Na+,K+-ATPase: Synthesis, structure–activity relationship and 3D-quantitative structure–activity relationship of derivatives at position 6 on the androstane scaffold

Mauro Gobbini; Silvia Armaroli; Leonardo Banfi; Alessandra Benicchio; Giulio Carzana; Patrizia Ferrari; Giuseppe Giacalone; Giuseppe Marazzi; Barbara Moro; Simona Sputore; Marco Torri; Maria Pia Zappavigna; Alberto Cerri

We report the synthesis and biological properties of novel analogues of Istaroxime acting as positive inotropic compounds through the inhibition of the Na(+),K(+)-ATPase. We explored the chemical space around the position 6 of the steroidal scaffold by changing the functional groups at that position and maintaining a basic oximic chain in position 3. Some compounds showed inhibitory potencies of the Na(+),K(+)-ATPase higher than Istaroxime and many of the compounds tested in vivo were safer than digoxin, the classic digitalis compound currently used for the treatment of congestive heart failure as inotropic agent. The 3D-QSAR analyses using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods have been successfully applied to a set of 63 androstane derivatives as Na(+),K(+)-ATPase inhibitors. The contour plots provide many useful insights into relationships between structural features and inhibitory potency.


Journal of Organic Chemistry | 1999

A User-Friendly Entry to 2-Iodoxybenzoic Acid (IBX)

Marco Frigerio; and Marco Santagostino; Simona Sputore


Journal of Organic Chemistry | 1995

Oxidation of Alcohols with o-Iodoxybenzoic Acid in DMSO: A New Insight into an Old Hypervalent Iodine Reagent

Marco Frigerio; Marco Santagostino; Simona Sputore; Giovanni Palmisano


Journal of Medicinal Chemistry | 1997

17β-(3-Furyl)-5β-androstane-3β,14β,17α-triol (PST 2238). A Very Potent Antihypertensive Agent with a Novel Mechanism of Action

Luisa Quadri; Giuseppe Bianchi; Alberto Cerri; Giorgio Fedrizzi; Patrizia Ferrari; Mauro Gobbini; Piero Melloni; Simona Sputore; Marco Torri


Journal of Medicinal Chemistry | 2003

Structure-Based Design and Synthesis of Novel Potent Na+,K+-ATPase Inhibitors Derived from a 5α,14α-Androstane Scaffold as Positive Inotropic Compounds

Sergio De Munari; Alberto Cerri; Mauro Gobbini; Nicoletta Almirante; Leonardo Banfi; Giulio Carzana; Patrizia Ferrari; Giuseppe Marazzi; Rosella Micheletti; Antonio Schiavone; Simona Sputore; Marco Torri; Maria Pia Zappavigna; Piero Melloni


Archive | 1997

New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Munari Sergio De; Elena Folpini; Marco Frigerio; Piero Melloni; Fulvio Serra; Simona Sputore


Archive | 2001

Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione and its analogues

Mauro Gobbini; Giulio Carzana; Simona Sputore


Archive | 1997

6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Sergio De Munari; Elena Folpini; Marco Frigerio; Piero Melloni; Fulvio Serra; Simona Sputore


Synlett | 1997

3αβ-Hydroxy-7αβ-methylperhydroinden-4-one Derivatives en route to Analogues of Cardenolides

Marco Frigerio; Marco Santagostino; Simona Sputore


Archive | 2007

Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Alberto Cerri; Marco Torri; Silvia Armaroli; Leonardo Banfi; Giuseppe Bianchi; Giulio Carzana; Patrizia Ferrari; Rosamaria Micheletti; Simona Sputore; Maria Pia Zappavigna

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