Simona Sputore
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Publication
Featured researches published by Simona Sputore.
Bioorganic & Medicinal Chemistry | 2010
Mauro Gobbini; Silvia Armaroli; Leonardo Banfi; Alessandra Benicchio; Giulio Carzana; Patrizia Ferrari; Giuseppe Giacalone; Giuseppe Marazzi; Barbara Moro; Simona Sputore; Marco Torri; Maria Pia Zappavigna; Alberto Cerri
We report the synthesis and biological properties of novel analogues of Istaroxime acting as positive inotropic compounds through the inhibition of the Na(+),K(+)-ATPase. We explored the chemical space around the position 6 of the steroidal scaffold by changing the functional groups at that position and maintaining a basic oximic chain in position 3. Some compounds showed inhibitory potencies of the Na(+),K(+)-ATPase higher than Istaroxime and many of the compounds tested in vivo were safer than digoxin, the classic digitalis compound currently used for the treatment of congestive heart failure as inotropic agent. The 3D-QSAR analyses using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods have been successfully applied to a set of 63 androstane derivatives as Na(+),K(+)-ATPase inhibitors. The contour plots provide many useful insights into relationships between structural features and inhibitory potency.
Journal of Organic Chemistry | 1999
Marco Frigerio; and Marco Santagostino; Simona Sputore
Journal of Organic Chemistry | 1995
Marco Frigerio; Marco Santagostino; Simona Sputore; Giovanni Palmisano
Journal of Medicinal Chemistry | 1997
Luisa Quadri; Giuseppe Bianchi; Alberto Cerri; Giorgio Fedrizzi; Patrizia Ferrari; Mauro Gobbini; Piero Melloni; Simona Sputore; Marco Torri
Journal of Medicinal Chemistry | 2003
Sergio De Munari; Alberto Cerri; Mauro Gobbini; Nicoletta Almirante; Leonardo Banfi; Giulio Carzana; Patrizia Ferrari; Giuseppe Marazzi; Rosella Micheletti; Antonio Schiavone; Simona Sputore; Marco Torri; Maria Pia Zappavigna; Piero Melloni
Archive | 1997
Munari Sergio De; Elena Folpini; Marco Frigerio; Piero Melloni; Fulvio Serra; Simona Sputore
Archive | 2001
Mauro Gobbini; Giulio Carzana; Simona Sputore
Archive | 1997
Sergio De Munari; Elena Folpini; Marco Frigerio; Piero Melloni; Fulvio Serra; Simona Sputore
Synlett | 1997
Marco Frigerio; Marco Santagostino; Simona Sputore
Archive | 2007
Alberto Cerri; Marco Torri; Silvia Armaroli; Leonardo Banfi; Giuseppe Bianchi; Giulio Carzana; Patrizia Ferrari; Rosamaria Micheletti; Simona Sputore; Maria Pia Zappavigna