Sinan Kocatürk

Efficacy of platelet-rich fibrin matrix on viability of diced cartilage grafts in a rabbit model.

The objective of this study was to compare the viability of cartilage grafts embedded in platelet‐rich fibrin matrix (PRFM) wrapped with no material (bare diced cartilage grafts), oxidized methylcellulose (Surgicel), or acellular dermal tissue (AlloDerm).

The Use of Bipolar Electrocautery Tonsillectomy in Patients with Pediatric Respiratory Tract Obstruction

DOI: 10.4328/JCAM.1915 Received: 20.07.2013 Accepted: 29.07.2013 Printed: 01.09.2013 J Clin Anal Med 2013;4(suppl 1): 36-9 Corresponding Author: Olcay Murat Disli, Department of Cardiovascular Surgery, Inonu University Faculty of Medicine, 44280, Malatya, Turkey. T.: +90 4223410660/3905 F.: +90 4223410036 E-Mail: olcay.disli@inonu.edu.tr Ozet Bu yazida, primer travmatik inferior omuz cikigini takiben olusan aksiller arter yaralanmasi olgusu sunulmaktadir. Ekstremiteyi tehdit eden bu yaralanmanin klinik muayene esnasindaki patognomonik triad temelinde olusan bulgularla saptanmasina yonelik supheyi artirmak ve bunu izleyen tedavi ve sonuclarla ilgili guncel dusunceyi pekistirmek amaclandi. Bildigimiz kadariyla, Ingilizce literaturde genc erkek bir hastada primer travmatik inferior omuz cikiginda vaskuler yaralanmayi tarif eden tek yayindir.

Presence of vascular loops entering internal acoustic channel may increase risk of Sudden sensorineural hearing loss and reduce recovery of these patients.

To analyze whether there is correlation between branching patterns of anterior inferior cerebellar artery/posterior inferior cerebellar artery (AICA/PICA) in cerebellopontine angle (CPA) area, as demonstrated by three‐dimensional fast imaging employing steady‐state acquisition (3D FIESTA) magnetic resonance imaging (MRI) and 1) idiopathic sudden sensorineural hearing loss (ISSNHL) outcomes and 2) recovery of ISSNHL.

New inflammatory parameters in laryngopharyngeal reflux

OBJECTIVES To investigate new inflammatory markers in patients with laryngopharyngeal reflux and determine whether these inflammatory parameters change in response to laryngopharyngeal reflux treatment. METHODS Complete blood count was evaluated to obtain platelet count and mean platelet volume and calculate neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Laryngopharyngeal reflux patients underwent three-month lansoprazole treatment. RESULTS The study included 45 laryngopharyngeal reflux patients (9 men (20 per cent); mean age, 37.4 ± 11.6 years) and 35 healthy age- and sex-matched controls (7 men (20 per cent); mean age, 38.6 ± 8.9 years). The study group had significantly higher platelet-to-lymphocyte ratios and lower mean platelet volumes than the control group (p = 0.004 and p = 0.047, respectively). There was a significant correlation between platelet-to-lymphocyte ratios and initial inflammatory symptoms (reflux symptom index, p = 0.025; reflux finding score, p = 0.013). There was also a significant correlation between mean platelet volume increase and symptom resolution in the first and third months of treatment (p = 0.04 and p = 0.03, respectively). CONCLUSION Platelet-to-lymphocyte ratio, a new inflammatory marker of chronic inflammation, was significantly higher in laryngopharyngeal reflux patients. Moreover, these patients had significantly lower mean platelet volume values, which increased with post-treatment symptom improvement.

Giant Thyroid Nodule Atypically Located in The Carotid Triangle of The Neck: A Case Report

DOI: 10.4328/JCAM.586 Received: 17.01.2011 Accepted: 02.03.2011 Printed: 01.05.2016 J Clin Anal Med 2016;7(3): 402-4 Corresponding Author: Guclu Kaan Beriat, Ufuk Universitesi Tip Fakultesi Dr. Ridvan Ege Hastanesi Kulak Burun Bogaz Anabilimdali, Balgat, 06520, Ankara, Turkiye. T.: +90 3122044175 F.: +90 3122847786 E-Mail: beriat4@gmail.com Ozet Ektopik tiroid dokusu tiroid dokusunun anormal migrasyonuyla olusan nadir gorulen bir tiroid patolojisidir. Yaklasik olarak 100,000-300,000 dogumda bir gorulur ve genellikle asemptomatiktir. Tiroid doku hiperplazisine bagli olarak, asemptomatik ektopik tiroid dokusu buyuyerek boyun kitlesi seklinde semptomatik hale gelebilir. Trakea onundeki normal lokalizasyonu disinda tiroid bezi, dil koku ile trakea arasinda genellikle orta hatta herhangi bir seviyede gorulebilir. 71 yasinda erkek hasta, boyun sag tarafinda, sag karotid ucgende 5x4x3 cm boyutlarinda kitle ile kulak burun bogaz poliklinigimize basvurdu. Yapilan ince igne aspirasyon biyopsisi sonucu tiroid dokusu olarak rapor edildi ve takiben kitle genel anestezi altinda eksize edildi. Yapilan patolojik degerlendirmesi sonucunda kitlenin atipik olarak yerlesim gosteren ektopik yerlesimli tiroid nodulu oldugu anlasildi. Hastanin yapilan bir yillik takibinde herhangi bir komplikasyonla karsilasilmadi.

Microdebrider Tonsillotomy in Children with Obstructive Tonsillar Hypertrophy

Aim: To compare intracapsular microdebrider tonsillotomy with conventional cold dissection tonsillectomy in the management of tonsillar hypertrophy causing obstructive airway problems in children. Material and Method: 37 children who underwent microdebrider tonsillotomy were compared with other 45 children who had conventional cold dissection tonsillectomy to examine intraoperative blood loss, operation time, duration of oral intake, intake of analgesics, recovery time and post-operative pain. Results: Children who underwent intra-capsular micro-debrider tonsillotomy had significantly less pain throughout their recovery period than those who had conventional tonsillectomy. In the microdebrider tonsillotomy group intraoperative blood loss, operation time, duration of oral intake, intake of analgesics, and postoperative pain score were found to be less than the conventional tonsillectomy group scores(p <0,05). Tonsillar hypertrophy recurred in two patients of micro-debrider tonsillotomy group. Discussion: Intracapsular tonsillotomy is as effective and safe as conventional tonsillectomy to relieve obstructive sleep apnea in pediatric patients. Intracapsular microdebrider tonsillotomy reduces postoperative pain, improves quality of life and shorthens the recovery time. Therefore; this procedure is more tolerable in children with obstructive tonsillar hypertropy in respect to conventional tonsillectomy.

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

OBJECTIVE To assess the efficacy of the application of platelet-rich plasma (PRP) in the healing process of acute tympanic membrane perforations (TMPs). MATERIALS AND METHODS Acute TMPs were made in both the ears of 12 New Zealand rabbits. Plasma gel was applied at the right tympanic membrane (TM) of the same animal until the perforations were closed. The left TM was left untreated. On days 1, 4, 7, 10, 13, 16, 21, 28, and 35, the TMs were monitored to check the closure of perforations. The days of perforation closure for the 2 groups were compared using the paired t-test. The animals were sacrificed 2 months after making the perforations. Seven histopathological parameters were reviewed by 2 blinded pathologists: acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, sclerosis, fibroblastic reaction, and an increase in the thickness of the squamous epithelial layer. The presence or absence of each histological parameter in both groups was compared using the Pearson Chi-square test. RESULTS The average number of days for closure in the plasma gel group was 12 (range 8-18 days) and that in the control group was 17.7 (range 8-31 days). The difference was statistically significant (p=0.0145). There was no sclerosis or fibroblastic reaction in any of the specimens. No statistically significant difference was seen between the 2 groups with respect to acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, and an increase in thickness of the squamous epithelial layer (p>0.05). CONCLUSION Platelet-rich plasma fastens TMP closure; in long term, the eventual outcome is both microscopically and macroscopically same for the control as well as study groups in a rabbit traumatic TMP model. We believe that this study will encourage the clinical use of PRP for acute TMPs and trigger clinical studies in this field.

Effects of the Autologous Platelet-Rich Plasma in Nasal Pack on Postoperative Quality of Life.

Aim: The authors aimed to research the effects of autologous platelet-rich plasma, which is known for the positive effects on wound healing, on postoperatif living quality of the patients after using on nasal surgery. Methods: Patients who undergo nasal operation according to randomized patients choice have been injected with saline merocel pack and platelet-rich plasma (PRP) in their nasal path. Postoperative is followed by 1 month; Nose Obstruction Symptom Evaluation (NOSE) scala score, bleeding, pain, and crust rate have been compared between 2 groups. Results: As a result of the 1 month follow-up, it was seen that the treatment group experienced better results in terms of NOSE scale than the control group patients and this was significant difference in terms of NOSE. Less bleeding and crust was seen on the treatment group patients than the control group patients and statically significant difference was found. In terms of visual analogue scale score no statically significant difference was found between 2 groups. Conclusion: According to the authors’ study on PRP, the authors found out that by using PRP wound can be healed faster in early period of postoperative. It was seen with the authors’ research that on postoperative early period crusts, bleeding and postoperative complaints are lesser.

Plasma Glycated Albumin Levels Clearly Detect Hearing Loss and Atherosclerosis in Patients with Impaired Fasting Glucose.

Objective: To describe the relationship between atherosclerosis and hearing thresholds in prediabetic patients with impaired fasting glucose (IFG) and to determine the efficacy of glycated albumin in predicting carotid artery atherosclerosis in patients with isolated IFG. Subjects and Methods: The study included 82 patients (aged 53.73-80 years) divided into two groups based on fasting glucose levels, the IFG group: 59 patients (32 females, 54.2%), and the normal fasting plasma glucose level group: 23 patients (12 females, 52.2%). Patients underwent audiological testing to determine hearing thresholds, and carotid intima-media thickness (CIMT) was measured using carotid artery Doppler sonography. Multivariate analyses were performed to determine whether or not the plasma glycated albumin levels could predict hearing loss and CIMT. Results: Patients in the IFG group (mean age: 59.8 ± 9.5 years) had higher hearing thresholds and pure-tone average scores (PTA) than those in the group with normal glucose levels (mean age: 56.2 ± 10.1 years) (left ear: 27.65 ± 8.85 vs. 25.75 ± 21.96 dB, p = 0.021; right ear: 29.22 ± 8.51 vs. 22.39 ± 6.99 dB, p = 0.001). The CIMT was significantly higher in the IFG group than the control group (0.75 ± 0.26 vs. 0.56 ± 0.16 mm, p < 0.001 for the left and 0.74 ± 0.26 vs. 0.51 ± 0.19 mm, p < 0.001 for the right carotid arteries). Glycated albumin levels were independently related with increased CIMT (left CIMT: r = 0.32, p = 0.003; right CIMT: r = 0.42, p < 0.001), and serum glycated albumin levels were significantly associated with PTA (left ear: r = 0.28, p = 0.01; right ear: r = 0.30, p = 0.006). Conclusion: Sensorineural hearing loss was more common in patients with IFG. Plasma glycated albumin levels were strongly correlated with CIMT and carotid plaques as a marker of atherosclerosis and with hearing impairment thought to develop due to atherosclerosis in patients with IFG.

Temporal Bone Posterior Wall Defect, a New Clinic Entity?

OBJECTIVE To define clinical and audiological findings in patients with temporal bone posterior wall defects (TBPWD) and to investigate possible relationships between these findings and the characteristics of the defect. MATERIALS AND METHODS The computed tomography (CT) views of 1198 patients with vestibulocochlear symptoms between 2007 and 2012 were retrospectively evaluated, and TBPWD and associated anomalies were investigated. Patients who had TBPWD were called back, and clinical and audiological examinations (tympanometry, pure tone audiometry, acoustic reflexes, and otoacoustic emission) were performed. RESULTS Twenty-eight (2.34%) patients had TBPWD. Twenty-three of them were eligible for the study. Size of the defect was significantly correlated with the presence of tinnitus and/or vertigo (p<0.005). The cut-off values for the largest size of TBPWD were 1.65 mm [sensitivity: 0.67 and specificity: 0.77 (95% CI: 0.58-0.97); p=0.04] in case of the presence of tinnitus and 1.85 for vertigo (sensitivity: 0.78 and specificity: 0.86 (95% CI: 0.67-0.99); p=0.006). In pure tone audiometry tests, mixed-type hearing loss was present in four (17%) patients, sensorineural hearing loss was present in three (13%) patients, and conductive-type hearing loss was present only in one (4%) patient. Otoacoustic emission tests revealed significant differences in signal/noise ratios at frequencies of 500, 750, 1000, and 6000 Hz. CONCLUSION For the first time in the literature, we defined clinical and audiological findings in patients with TBPWDs. These defects seem to cause more prevalent symptoms of vertigo and tinnitus and disturb the audiological characteristics of patients.