Snezana Lukic
University of Belgrade
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Featured researches published by Snezana Lukic.
Digestive Surgery | 2011
Snezana Lukic; Aleksandra Nikolic; Tamara Alempijevic; Dragan Popovic; Aleksandra Sokic Milutinovic; Milenko Ugljesic; Srbislav Knezevic; Biljana Milicic; Dragica Dinic; Dragica Radojkovic
The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors.
Digestive Surgery | 2008
Ivan Jovanovic; Tamara Alempijevic; Snezana Lukic; Srboljub Knezevic; Dragan Popovic; Vladimir Dugalic; Marjan Micev; Miodrag Krstic
Background: Cystic dystrophy in heterotopic pancreas (CDHP) is a rare condition. It has been recently reported as one of the etiologic obstructive factors of chronic pancreatitis. The aim of our study was to evaluate diagnosis and management of CDHP in the duodenal wall in a surgical series. Methods: We retrospectively reviewed 13 patients with available clinical data. Results: There were 11 male and 2 female patients, median age 42 years. The average duration of symptoms was 7.5 months. 6 of them (46%) were alcoholics, and 10 (75%) had signs of chronic pancreatitis. Almost all of them (12/13; 92%) revealed disabling pain, while 4 (31%) had associated jaundice. In 4 of 7 patients (57%), weight loss was observed. Most often the patients were suspected of having pancreatic head mass with or without signs of chronic pancreatitis. All patients underwent surgical treatment. Pathological examination showed the presence of cysts surrounded by inflammation and fibrosis in the duodenal wall, as well as the presence of chronic pancreatitis in the pancreas proper. Conclusions: Cystic dystrophy of the duodenal wall represents a significant proportion of patients undergoing surgery for chronic pancreatitis. Pancreatoduodenectomy is the best therapeutic option.
Journal of Digestive Diseases | 2015
Biljana Stankovic; Sanja Dragasevic; Dragan Popovic; Branka Zukic; Nikola Kotur; Aleksandra Sokic-Milutinovic; Tamara Alempijevic; Snezana Lukic; Tomica Milosavljevic; Gordana Nikcevic; Sonja Pavlovic
Research on inflammatory bowel disease (IBD) has highlighted genes involved in the regulation of inflammatory responses as contributors to disease pathogenesis. This study aimed to evaluate the associations between IBD and variations in NOD2, TLR4, TNF‐α, IL‐6, IL‐1β and IL‐1RN genes, and to use the genetic data obtained in predictive modeling.
World Journal of Gastroenterology | 2015
Srbislav Knezevic; Igor Ignjatovic; Snezana Lukic; Slavko Matic; Vladimir Dugalic; Djordje Knezevic; Marjan Micev; Sanja Dragasevic
Primary retroperitoneal mucinous cystic tumors are extremely rare. These tumors can be classified as a primary retroperitoneal mucinous cystadenoma with or without borderline malignancy or primary retroperitoneal mucinous cystadenocarcinoma. The most common of these is primary retroperitoneal mucinous cystadenoma, which almost always occurs in female patients; only ten cases have been reported in males. The most common clinical findings for this tumor type include nonspecific abdominal pain and a palpable abdominal mass. A definitive diagnosis is usually obtained from histopathology after surgical excision. Here, we report the case of a 60-year-old female patient who complained of abdominal pain that had been present for 3 mo and presented with a palpable abdominal mass. Multidetector computed tomography scanning revealed a large, unilocular cystic mass in the left retroperitoneal space. Surgical intervention was performed and the tumor was completely removed. Histopathologic examination confirmed that the tumor was a primary retroperitoneal mucinous cystadenoma. Two years after surgery, the patient remains disease free.
European Journal of Gastroenterology & Hepatology | 2017
Sanja Dragasevic; Biljana Stankovic; Tomica Milosavljevic; Aleksandra Sokic-Milutinovic; Snezana Lukic; Tamara Alempijevic; Branka Zukic; Nikola Kotur; Gordana Nikcevic; Sonja Pavlovic; Dragan Popovic
Objectives The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-&agr;, IL-6, IL-1&bgr;, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn’s disease (CD) patients. Patients and methods We genotyped 167 IBD patients using PCR-based methodology and tested for disease genotype–phenotype associations. Results In CD patients ileal localization of disease was more frequent in NOD2 variant carriers. Ileal CD was associated with IL-6 GC+CC genotypes, identifying C allele as a possible marker of increased risk for ileal CD. In CD patients a positive family history for IBD was related to earlier onset of disease, higher risk for CD-related surgery, and appendectomy. CD patients who are TLR4 299Gly carriers are at higher risk for surgery at onset of the disease compared with TLR4 299Asp variant carriers. The presence of granuloma in biopsy specimens was more frequent in patients in whom a diagnosis of CD was made during emergency surgery. Multivariate analysis showed that CD carriers of the 299Gly allele had a 4.6-fold higher risk for emergency surgery before CD diagnosis is established compared with noncarriers, suggesting an aggressive disease course. Granuloma in endoscopic biopsies is detected 5.4-fold more frequently in patients treated surgically at the time of diagnosis. Conclusion Genetic variants together with epidemiological and clinical data of IBD patients could potentially be used as predictors of the disease course.
Clinical Immunology | 2018
Sanja Dragasevic; Biljana Stankovic; Aleksandra Sokic-Milutinovic; Tomica Milosavljevic; Tamara Milovanovic; Snezana Lukic; Sanja Srzentic Drazilov; Kristel Klaassen; Nikola Kotur; Sonja Pavlovic; Dragan Popovic
BACKGROUND AND AIMS Mucosal gene expression have not been fully enlightened in inflammatory bowel disease (IBD). Aim of this study was to define IL23A, IL17A, IL17F and TLR9 expression in different IBD phenotypes. METHODS Evaluation of mRNA levels was performed in paired non-inflamed and inflamed mucosal biopsies of newly diagnosed 50 Crohns disease (CD) and 54 ulcerative colitis (UC) patients by quantitative real-time PCR analysis. RESULTS IL17A and IL17F expression levels were significantly increased in inflamed IBD mucosa. Inflamed CD ileal and UC mucosa showed increased IL23A, while only inflamed CD ileal samples showed increased TLR9 mRNA level. Correlation between analysed mRNAs levels and endoscopic and clinical disease activity were found in UC, but only with clinical activity in CD. CONCLUSION Both CD and UC presented expression of Th17-associated genes. Nevertheless, expression profiles between different disease forms varies which should be taken into account for future research and therapeutics strategies.
Canadian Journal of Gastroenterology & Hepatology | 2017
Tamara Alempijevic; Milica Stojkovic Lalosevic; Igor Dumic; Nevena Jocic; Aleksandra Pavlovic Markovic; Sanja Dragasevic; Ivana Jovicic; Snezana Lukic; Dragan Popovic; Tomica Milosavljevic
Objective Keeping in mind the rising prevalence of nonalcoholic fatty liver disease (NAFLD) and the need to establish noninvasive tests for its detection, the aim of our study was to investigate whether platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) can predict the presence of liver fibrosis in this group of patients. Methods In 98 patients with NAFLD and 60 healthy volunteers, complete blood counts with automated differential counts were performed and values of PC, PDW, MPV, and PCT were analyzed. Results Patients with NAFLD had lower PC and higher MPV, PCT, and PDW compared to the controls (P < 0.05). When NAFLD group was stratified according to severity of liver fibrosis, there was a statistically significant difference in the average values of PDW and PC between the groups (P < 0.05). Conclusion Patients with NAFLD have significantly higher values of PCT, PDW, and MPV when compared to the healthy controls. Further studies are needed to establish their potential use for prediction of the degree of liver steatosis and fibrosis in NAFLD patients.
Archive | 2014
Aleksandra Sokic-Milutinovic; Dragan Popovic; Sanja Dragasevic Tamara Alempijevic; Snezana Lukic; Aleksandra Pavlovic-Markovic
Vojnosanitetski Pregled | 2018
Snezana Lukic; Sanja Dragasevic; Sanja Zgradic; Milena Todorovic; Srdjan Djuranovic; Bosko Andjelic; Dragan Popovic
Vojnosanitetski Pregled | 2017
Dragan Popovic; Aleksandra Sokic-Milutinovic; Srdjan Djuranovic; Tamara Alempijevic; Sanja Zgradic; Vera Matovic; Ljubisa Toncev; Snezana Lukic