Soo S. Ko | Researchain

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Featured researches published by Soo S. Ko.

Bioorganic & Medicinal Chemistry Letters | 2002

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure–activity relationships

Dean A. Wacker; Joseph B. Santella; Daniel S. Gardner; Jeffrey G. Varnes; Melissa Estrella; George V. Delucca; Soo S. Ko; Keiichi Tanabe; Paul S. Watson; Patricia K. Welch; Maryanne B. Covington; Nicole Stowell; Eric A. Wadman; Paul Davies; Kimberly A. Solomon; Robert C. Newton; George L. Trainor; Steven M. Friedman; Carl P. Decicco; John V. Duncia

CCR3 antagonist leads with IC(50) values in the microM range were converted into low nM binding compounds that displayed in vitro inhibition of human eosinophil chemotaxis induced by human eotaxin. In particular, 4-benzylpiperidin-1-yl-n-propylureas and erythro-3-(4-benzyl-2-(alpha-hydroxyalkyl)piperidin-1-yl)-n-propylureas (obtained via Beak reaction of N-BOC-4-benzylpiperidine) exhibited single digit nanomolar IC(50) values for CCR3.

Archive | 1998

4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors

Jeffrey W. Corbett; Soo S. Ko

Archive | 1999

2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity

Paul S. Watson; Soo S. Ko; George V. Delucca; John V. Duncia; Joseph B. Santella; Dean A. Wacker

Bioorganic & Medicinal Chemistry Letters | 2004

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists

Jeffrey G. Varnes; Daniel S. Gardner; Joseph B. Santella; John V. Duncia; Melissa Estrella; Paul S. Watson; Cheryl M. Clark; Soo S. Ko; Patricia K. Welch; Maryanne B. Covington; Nicole Stowell; Eric A. Wadman; Paul Davies; Kimberley Solomon; Robert C. Newton; George L. Trainor; Carl P. Decicco; Dean A. Wacker

Archive | 2001

N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity

Soo S. Ko; James Russell Pruitt; Dean A. Wacker; Douglas G. Batt

Bioorganic & Medicinal Chemistry Letters | 2008

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.

Joseph B. Santella; Daniel S. Gardner; Wenqing Yao; Chongsheng Shi; Prabhakar Reddy; Andrew J. Tebben; George V. Delucca; Dean A. Wacker; Paul S. Watson; Patricia K. Welch; Eric A. Wadman; Paul Davies; Kimberly A. Solomon; Dani M. Graden; Swamy Yeleswaram; Sandhya Mandlekar; Ilona Kariv; Carl P. Decicco; Soo S. Ko; Percy H. Carter; John V. Duncia

Bioorganic & Medicinal Chemistry Letters | 2007

CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.

James Russell Pruitt; Douglas G. Batt; Dean A. Wacker; Lori L. Bostrom; Shon K. Booker; Erin McLaughlin; Gregory C. Houghton; Jeffrey G. Varnes; David D. Christ; Maryanne B. Covington; Anuk M. Das; Paul Davies; Danielle M. Graden; Ilona Kariv; Yevgeniya Orlovsky; Nicole Stowell; Krishna Vaddi; Eric A. Wadman; Patricia K. Welch; Swamy Yeleswaram; Kimberly A. Solomon; Robert C. Newton; Carl P. Decicco; Percy H. Carter; Soo S. Ko

Bioorganic & Medicinal Chemistry Letters | 2006

2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists : Synthesis and selectivity

Paul S. Watson; Bin Jiang; Kim Harrison; Nao Asakawa; Patricia K. Welch; Maryanne B. Covington; Nicole Stowell; Eric A. Wadman; Paul Davies; Kimberly A. Solomon; Robert C. Newton; George L. Trainor; Steven M. Friedman; Carl P. Decicco; Soo S. Ko

Bioorganic & Medicinal Chemistry Letters | 2008

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists

Daniel S. Gardner; Joseph B. Santella; Andrew J. Tebben; Douglas G. Batt; Soo S. Ko; Sarah C. Traeger; Patricia K. Welch; Eric A. Wadman; Paul Davies; Percy H. Carter; John V. Duncia

Archive | 2011