Sophie Biver
University of Liège
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Publication
Featured researches published by Sophie Biver.
Nature | 2008
Sophie Biver; Hendrica Belge; Soline Bourgeois; Pascale Van Vooren; Marta Nowik; Sophie Scohy; Pascal Houillier; Josiane Szpirer; Claude Szpirer; Carsten A. Wagner; Olivier Devuyst; Anna Maria Marini
The kidney has an important role in the regulation of acid–base homeostasis. Renal ammonium production and excretion are essential for net acid excretion under basal conditions and during metabolic acidosis. Ammonium is secreted into the urine by the collecting duct, a distal nephron segment where ammonium transport is believed to occur by non-ionic NH3 diffusion coupled to H+ secretion. Here we show that this process is largely dependent on the Rhesus factor Rhcg. Mice lacking Rhcg have abnormal urinary acidification due to impaired ammonium excretion on acid loading—a feature of distal renal tubular acidosis. In vitro microperfused collecting ducts of Rhcg-/- acid-loaded mice show reduced apical permeability to NH3 and impaired transepithelial NH3 transport. Furthermore, Rhcg is localized in epididymal epithelial cells and is required for normal fertility and epididymal fluid pH. We anticipate a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract.
Journal of Industrial Microbiology & Biotechnology | 2013
Sophie Biver; Micheline Vandenbol
Journal of Industrial Microbiology & Biotechnology | 2014
Sophie Biver; Aurore Stroobants; Daniel Portetelle; Micheline Vandenbol
Journal of Microbiology and Biotechnology | 2013
Sophie Biver; Sébastien Steels; Daniel Portetelle; Micheline Vandenbol
Archive | 2013
Sophie Biver; Benjamin Dubois; Aurore Stroobants; Daniel Portetelle; Micheline Vandenbol
Archive | 2013
Marjolaine Martin; Sophie Biver; Tristan Barbeyron; Gurvan Michel; Daniel Portetelle; Micheline Vandenbol
Archive | 2013
Marjolaine Martin; Sophie Biver; Tristan Barbeyron; Gurvan Michel; Daniel Portetelle; Micheline Vandenbol
Archive | 2012
Sophie Biver; Christel Mattéotti; Micheline Vandenbol
Archive | 2012
Marjolaine Martin; Sophie Biver; Tristan Barbeyron; Gurvan Michel; Micheline Vandenbol
Archive | 2011
Sophie Biver; Daniel Portetelle; Micheline Vandenbol