Stefania Rametta

Factors associated with adherence to the Mediterranean diet among adolescents living in Sicily, Southern Italy.

The present study aimed to examine the factors associated with increased Mediterranean diet (MD) adherence among a sample of Italian adolescents. A cross-sectional survey was conducted on 1135 students (13–16 years) attending 13 secondary schools of Sicily, southern Italy. Validated instruments were used for dietary assessment and the KIDMED score to assess adolescents’ adherence to the MD. A higher adherence to the MD was associated with high socioeconomic status (Odds Ratio [OR] 1.53, 95% Confidence Interval [CI]: 1.03–2.26) and high physical activity (OR 1.19, 95% CI: 1.02–1.70), whereas lower adherence was associated with living in an urban environment (OR 0.65, 95% CI: 0.44–0.97) and being obese (OR 0.59, 95% CI: 0.37–0.94). The adolescents’ KIDMED scores were inversely associated with adolescents’ intake of sweets, fast foods, fried foods, and sugary drinks, and directly with fruit, vegetables, pasta, fish, and cheese intakes. Urban-living adolescents were less likely to eat fruit and more prone to consume meat, sugary drinks, and fast food than rural-living adolescents. The latter were more likely to eat sweets and snacks. A general poor quality of food consumption in Italian adolescents away from the MD was reported, especially among those living in urban areas.

Mediterranean diet adherence and body composition among Southern Italian adolescents.

INTRODUCTION Adherence to the traditional Mediterranean diet has been associated with health benefits in young populations. The aim of this study was to evaluate the association between adherence to the Mediterranean diet and cardio-metabolic parameters in adolescents living in Sicily, Southern Italy. METHODS A cross-sectional study was conducted during two school years (2012-2013 and 2013-2014) on 1643 adolescents of 11-16 years attending 15 secondary schools. Socio-demographic, dietary, lifestyle, and anthropometric data were collected. The KIDMED score was used to evaluate the adherence to the Mediterranean diet. Linear and logistic regression models were used to test the association between the variable of interest and the outcomes. RESULTS A higher percentage of boys compared with girls was overweight (30.8% vs. 25.4%) and obese (28.7% vs. 18.5%) and only 9.1% had high adherence to the Mediterranean diet. Vegetable intake was negatively associated with being overweight/obese whereas higher intake of sweets, sugar-sweetened beverages, and fast foods was associated with overweight and obesity. A good adherence to the Mediterranean diet resulted in 30% decreased odds of being overweight or obese (odd ratio 0.70, 95% confidence interval: 0.56-0.87) in both boys and girls. An inverse correlation was found between KIDMED score and BMI, waist circumference and fat mass. No relation with blood pressure was found. CONCLUSIONS Mediterranean dietary pattern resulted significantly associated with weight status in adolescents. These results underline the importance of providing lifestyle and dietary habits education to prevent overweight and obesity in adolescent.

Resolution of Persistent Cystoid Macular Edema due to Central Retinal Vein Occlusion in a Vitrectomized Eye following Intravitreal Implant of Dexamethasone 0.7 mg.

We report the case of a 62-year-old woman with a history of vitreoretinal surgery for vitreous hemorrhage secondary to central retinal vein occlusion (CRVO). Because of the persistence of macular edema (ME), she received 2 intravitreal injections of bevacizumab 0.5 mg (Avastin®, Genentech/Roche) three months after vitrectomy, without functional or anatomical improvement. Six months after vitrectomy, she therefore received an intravitreal implant of dexamethasone 0.7 mg (Ozurdex®). An improvement in her best-corrected visual acuity and central macular thickness, as measured by optical coherence tomography, was detected 7 days after the injection, and complete resolution of the ME and retinal hemorrhages was observed 6 months after the injection. Dexamethasone intravitreal implant might be an effective treatment option in ME secondary to CRVO, also in vitrectomized eyes.

Sleep quality and duration is related with diet and obesity in young adolescent living in Sicily, Southern Italy

The aim of this study was to evaluate the association between sleeping habits, Mediterranean diet pattern, and weight status in an adolescent population. The sample consisted of 1586 individuals aged 11–14 years attending 15 secondary schools of Sicily, Southern Italy. School were randomly selected and the data collected during two school years. Anthropometric data was collected and body composition was assessed by bioelectrical impedance analysis. Demographic information, sleep duration, pediatric daytime sleepiness questionnaire (PDSS), physical activity and dietary habits (including adherence to the Mediterranean Diet using the KIDMED score) were further collected. The mean age was 12±0.7 and about 24% were overweight and obese. An inverse correlation between total sleep time and body mass index (β=−0.829, P=0.021), fat mass (β=−0.526, P=0.025), and waist circumference (β=−0.426, P=0.045) was found. Similar results were found for weekdays sleep time, while an inverse relationship was found with PDSS score. Adherence to Mediterranean Diet was higher in under/normal weight adolescent with a significant linear association between the KIDMED score and the PDSS, weekdays sleep time and total sleep time. Sleep duration was also associated positively with fruits and vegetable intake and negatively with sweet and snack consumption and eating outside habits. Short sleep duration and poor sleep were associated with an increase in BMI and fat mass as well as to unhealthy eating behaviors. These findings suggest that sleep patterns could be a potential target for obesity prevention programs in young adolescence.

Radiation Macular Edema after Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved by an Intravitreal Dexamethasone 0.7-mg Implant

Purpose: To report the effective treatment of radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma with a dexamethasone 0.7-mg (Ozurdex®) intravitreal implant. Methods: An interventional case report with optical coherence tomography (OCT) scans. Results: A 65-year-old Caucasian woman was suffering from radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma on her left eye. She had undergone one intravitreal injection of 0.5 mg bevacizumab (Avastin®, Genentech/Roche) in the following months without functional or anatomical improvement. Seven months after the development of radiation macular edema, she received a single intravitreal injection of dexamethasone 0.7 mg (Ozurdex). Four weeks following the injection, her best-corrected visual acuity improved from 0.3 to 0.5. Radiation macular edema resolved with a reduction of central retinal thickness from 498 µm before Ozurdex injection to 224 µm after Ozurdex injection, as measured by OCT scan. Conclusion: Dexamethasone 0.7 mg (Ozurdex) has proven to be an effective treatment option in retinal vein occlusion and noninfectious uveitis. It can also be considered as off-label treatment in radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma.

Pharmacological and dietary prevention for colorectal cancer.

BackgroundColorectal cancer (CRC) is a leading cause of cancer morbidity and mortality. People at higher risk are those individuals with a family history of CRC and familial adenomatous polyposis. Prevention and screening are two milestones for this disease. The aim of this study is to evaluate the chemopreventive role of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin and cyclooxygenase 2 inhibitors, some micronutrients (folic acid, calcium, selenium, antioxidants) and probiotics.DiscussionThe studies on aspiring reported promising results, but it is debatable whether aspirin should be used as chemoprevention, because of its side effects and because of poor efficacy evident in subjects at high risk. Similar results were reported for other non-aspirin NSAIDs, such as sulindac and celecoxib, which the potential adverse effects limit their use. Selenium role in prevention of various types of cancer as well as in colon adenomas are often inconclusive or controversial. Several studies suggested that calcium may have a possible chemopreventive effect on colon adenomas and CRC, although contrasting results are reported for the latter. A recent meta-analysis including 13 randomized trial suggested that folic acid supplementation had not a chemiopreventive action on CRC. Several studies investigated the association between antioxidants, administered alone or in combination, and CRC risk, both among general and at risk population, but only few of them supported statistically significant results.ConclusionThe results of this literature review showed an unclear role in CRC prevention of both pharmacological and dietary intervention. Despite several options are available to prevent colon cancer, it is challenging to identify a correct strategy to prevent CRC through pharmacological and dietary intervention due to the long latency of cancer promotion and development. Since some of the drugs investigated may have uncertain individual effects, it can be suggested to potentiate such effects by adding them together.

Social disparities, health risk behaviors, and cancer

BackgroundOverall cancer incidence rates decreased in the most recent time period in both men and women, largely due to improvements in surgical therapeutic approaches (tertiary prevention) and screening programs (secondary prevention), but differences in cancer incidence and survival according to socioeconomic status are documented worldwide. Health risk behaviors, defined as habits or practices that increase an individual’s likelihood of harmful health outcomes, are thought to mediate such inequalities.DiscussionObesity has been related with increased cancer incidence and mortality due to imbalance of leptin and adiponectin which are connected to activation of PI3K, MAPK, and STAT3 pathways and decreasing insulin/insulin-like growth factor (IGF)-1 and mTOR signaling via activation of 5 AMP-activated protein kinase (AMPK), respectively. Physical activity has been associated to prevent cancer by the aforementioned obesity-related mechanisms, but also increasing level of circulating vitamin D, which has been related to lower risk of several cancers, and increasing prostaglandin F2a and reducing prostaglandin E2, which are both related with cancer prevention and promotion, respectively. A large number of different substances may induce themselves a direct cytotoxicity and mutagenic action on cells by smoking, whereas alcohol promote immune suppression, the delay of DNA repair, inhibition of the detoxification of carcinogens, the production of acetaldehyde, and the contribution to abnormal DNA methylation. The combined smoking and alcohol drinking habits have been shown to increase cancer risk by smoke action of increasing the acetaldehyde burden following alcohol consumption and alcohol action of enhancing the activation of various procarcinogens contained in tobacco smoke.ConclusionsInterventions at the social level may be done to increase awareness about cancer risks and promote changing in unhealthy behaviors.

Eating and lifestyle habits in relation with weight status and place of living of adolescents in Sicily, Southern Italy

BACKGROUND: Obesity among adolescents has increased worldwide becoming a major public health issue. OBJECTIVE: The aim of this study was to investigate the relationship between eating and lifestyle habits, place of living, and weight status among adolescents living in Sicily, southern Italy. METHODS: Between March and June 2010 and 2011, a sample of 1135 rural and urban adolescents was selected to join the study. Validated questionnaire were used to assess eating and lifestyle habits. RESULTS: Rural students consumed during breakfast significantly higher amount of cereals, fruit juice, fruits, and home-made cakes over packaged snacks and reported to prefer home-made cakes and fruit as a snack whereas packaged snacks, baked goods and biscuits were preferred in the urban area. Lower BMI values observed among rural compared with urban students. Urban adolescents were found to be almost 2 times more likely to eat between meals ≥4 times per day and out of home ≥3 times per week. Unhealthy behaviours regarded also physical activity habits, being urban students less likely to practice physical activity and more likely to spend time on TV/computer. Comparisons of meals and physical activity habits by body composition revealed that obese adolescents were significantly associated with more frequent weekly out of home eating and breakfast, less sport practicing and more daily hours use of TV/computer. CONCLUSIONS: Our findings showed that specific intervention programs regarding education on eating and lifestyle habits should be altered for use in urban and rural settings.

Association Between Sugar-Sweetened Beverages Consumption and Body Composition in Relation to Salt Among Adolescent Resident in Sicily, Southern Italy

Aim: To explore the association between Sugar-Sweetened Beverages (SSBs) consumption and salt intake in relation to blood pressure and body composition in adolescents living in Sicily, southern Italy. Methods: From September 2012 to June 2014, 1643 students attending 15 secondary schools in the district of Catania were invited to participate. The information collected included demographics, anthropometric data (bioelectrical impedance), physical activity level, and dietary habits based a food frequency questionnaire validated for the Italian youth population. Results: The mean age of participants was 12.4 years and more than half (53.8%) were boys. The 30.1% and 24.5% of the sample was overweight or obese, respectively. The 30.5% of participants consumed sugary drinks every day. After adjusting for confounding factors, SSBs consumption was positively associated with salt intake, BMI, and fat mass. Blood pressure was associated with SSBs intake only in overweight/obese subjects, which was no more significant after adjustment for salt intake. Conclusion: There is an association between salt intake and SSBs consumption. SSBs intake has been linked to increased BMI and fat mass. SSBs and salt consumption should be discouraged, particularly among children and adolescents, and obesity prevention strategies should include information and education about both SSBs and salt.

Hysteroscope or Mini-Hysteroscope: HTA in a University Hospital in Italy

Objective: The HTA Committee of University Hospital “G. Rodolico” of Catania received the form with the purchase request of four hysteroscopes. HTA report was developed to answer the following questions: Policy question: What is the optimal use for mini hysteroscope for gynecological problems in terms of effectiveness, safety and economic costs compared to the alternatives? Research question: Are the mini hysteroscope for all gynecological problems safe, painless, effective and cost-effective? Methods: We have identified and described some different types of hysteroscopes available on the Italian market and performed a context analysis to show their impact in terms of spending and consumption. We performed a systematic review of literature in order to synthesize the evidence on comparative efficacy, safety, and pain relating to the use of technology in question. The evaluation was conducted using a multidisciplinary approach and has provided an analysis of the seven following domains: Health problem and current use of the technology Description and technical characteristic of technology Clinical effectiveness