Stephen G. Azevedo

Development of ultrasound tomography for breast imaging: technical assessment

Ultrasound imaging is widely used in medicine because of its benign characteristics and real-time capabilities. Physics theory suggests that the application of tomographic techniques may allow ultrasound imaging to reach its full potential as a diagnostic tool allowing it to compete with other tomographic modalities such as x-ray computer tomography, and MRI. This paper describes the construction and use of a prototype tomographic scanner and reports on the feasibility of implementing tomographic theory in practice and the potential of ultrasound (US) tomography in diagnostic imaging. Data were collected with the prototype by scanning two types of phantoms and a cadaveric breast. A specialized suite of algorithms was developed and utilized to construct images of reflectivity and sound speed from the phantom data. The basic results can be summarized as follows. (i) A fast, clinically relevant US tomography scanner can be built using existing technology. (ii) The spatial resolution, deduced from images of reflectivity, is 0.4 mm. The demonstrated 10 cm depth-of-field is superior to that of conventional ultrasound and the image contrast is improved through the reduction of speckle noise and overall lowering of the noise floor. (iii) Images of acoustic properties such as sound speed suggest that it is possible to measure variations in the sound speed of 5 m/s. An apparent correlation with x-ray attenuation suggests that the sound speed can be used to discriminate between various types of soft tissue. (iv) Ultrasound tomography has the potential to improve diagnostic imaging in relation to breast cancer detection.

Calculation of the rotational centers in computed tomography sinograms

An efficient method for accurately calculating the center-of-rotation, or projection center, for parallel computed tomography projection data, or sinograms, is described. This method uses all the data in the sinogram to estimate the center by a least-squares technique and requires no previous calibration scan. The method also finds the objects center-of-mass without reconstructing its image. Since the method uses the measured data, it is sensitive to noise in the measurements, but that sensitivity is relatively small compared to other techniques. Examples of its use on simulated and actual data are included. For fan-beam data over 360 degrees , two related methods are described to find the center in the presence or absence of a midline offset. >

Computed tomography systems and their industrial applications

Abstract x-Ray computed axial tomography (CT) provides cross-sectional views of materials, components, and assemblies for industrial non-destructive evaluation. We have applied CT imaging to quantitatively measure the 3-D distribution ogf x-ray attenuation at reasonably high resolutions. In our industrial x-ray CT-studies, we have centered on two technical approaches: a first-generation translate/rotate CT system that consist of well-collimated (∼ 0.55 mm) photon source detector, and a third-generation scanner that uses a fluoroscopy detector.

Computerized Ultrasound Risk Evaluation (CURE) System: Development of Combined Transmission and Reflection Ultrasound with New Reconstruction Algorithms for Breast Imaging

Our Computerized Ultrasound Risk Evaluation (CURE) system has been developed to the engineering prototype stage and generated unique data sets of both transmission and reflection ultrasound (US). This paper will help define the clinical underpinnings of the developmental process and interpret the imaging results from a similar perspective. The CURE project was designed to incorporate numerous diagnostic parameters to improve upon two major areas of early breast cancer detection. CURE may provide improved tissue characterization of breast masses and reliable detection of abnormal microcalcifications found in some breast cancers and ductal carcinoma in situ (DCIS). Current breast US is limited to mass evaluation, whereas mammography also detects and guides biopsy of malignant calcifications. Screening with CURE remains a distant goal, but improved follow-up of mammographic abnormalities may represent a feasible breakthrough.

Computerized tomography studies of concrete samples

Abstract X-ray computerized tomography (CAT or CT) is a sophisticated imaging technique that provides cross-sectional views of materials, components and assemblies for industrial nondestructive evaluation (NDE). We have studied the feasibility of using CT as an inspection tool for reinforced concrete and the use of multi-energy, linear, attenuation techniques to deduce variations in density (ρ) and/or atomic number (Z) that could be caused by varying the types of concrete mixes and/or compaction in the concrete itself. To perform this study, we designed and built a prototype medium-/high-energy (200- to 2000 keV) CT scanner — ZCAT — to image small concrete samples (± 30 cm in diameter and ± 75 cm in height) with a spatial resolution of about 2 mm. We used ZCAT to quantitatively inspect a 20 cm concrete cube with 1.27 cm diameter reinforcing bars (rebars) and to measure p and/or Z variations in a 20 cm diameter concrete cylinder. We describe the ZCAT scanner design, some of its physical limitations and the data-acquisition parameters used in our study. Our results and those of others [1,2] show that CT can be used to inspect reinforced concrete and to distinguish material p and/or Z variations within concrete.

VLSI architecture for high-speed image reconstruction: considerations for a fixed-point architecture

The amount of data generated by computed tomography (CT) scanners is enormous, making the image reconstruction operation slow, especially for 3-D and limited-data scans requiring iterative algorithms. The inverse Radon transform, commonly used for CT image reconstructions from projections, and the forward Radon transform are computationally burdensome for single-processor computer architectures. Fortunately, the forward Radon transform and the back projection operation (involved in the inverse Radon transform) are easily calculated using a parallel pipelined processor array. Using this array the processing time for the Radon transform and the back projection can be reduced dramatically. This paper describes a unified, pipelined architecture for an integrated circuit that computes both the forward Radon transform and the back projection operation at a 10 MHz data rate in a pipelined processor array. The trade-offs between computational complexity and reconstruction error of different interpolation schemes are presented along with an evaluation of the architectures noise characteristics due to finite word lengths. The fully pipelined architecture is designed to reconstruct 1024 pixel by 1024 pixel images using up to 1024 projections over 180 degrees. The chip contains three pipelined data-paths, each five stages long, and uses a single multiplier.

Hand-held forward-looking focused array mine detection with plane wave excitation

A novel handheld time-domain array GPR antipersonnel mine detection system prototype has been developed. Using an offset paraboloidal reflector antenna to collimate rays form an ultra-wideband feed, the transmitted microwave impulse is concentrated forward, in front of the antenna structure. The resulting wave is a non-uniform plane wave over the portion of ground be investigated, and is incident at 45 degrees to normal. As such, much of the ground reflect wave is directed further forward, away from the operator, the reflector, and the receiving antennas, thereby reducing clutter. However, the wave transmitted into the ground, which interacts with the target, tends to have significant backscatter returning toward the receiving antennas. These receiving antennas are configured in a 2 by 2 array to provide spatial focusing in both along and cross-track directions. This is accomplished by measuring and comparing the backscattered signal at each receiver in the narrow time window between the times when the ground reflected wave passes the receiver and before this wave re-reflects from the reflector components. 2D FDTD simulation of this parabolic reflector transmitter indicates that it generates a beam with a non-uniform planar wavefront, which scatters form rough ground primarily in the forward direction. The wave transmitted into the ground is also planar, propagating at the angle of refraction, and scattering fairly isotropically from a small penetrable target. This system has been built and tested at LLNL, using a very narrow pulse shape. LLNLs Micro-Impulse Radar (MIR) and custom-built wideband antenna elements operate in the 1.5 to 5 GHz range. One particular advantage of using the MIR module is its low cost: an important feature for mine detectors used in developing countries. Preliminary measured data indicates that the surface clutter is indeed reduced relative to the target signal, and that small non-metallic anti-personnel mines can be reliably detected at burial depths as shallow as 1 inch in both dry.

Potential of Computed Tomography for inspection of aircraft components

Computed Tomography (CT) using penetrating radiation (x- or gamma-rays) can be used in a number of aircraft applications. This technique results in 3D volumetric attenuation data that is related to density and effective atomic number. CT is a transmission scanning method that must allow complete access to both sides of the object under inspection; the radiation source and detection systems must surround the object. This normally precludes the inspection of some large or planar (large aspect ratio) parts of the aircraft. However, we are pursuing recent limited-data techniques using object model information to obtain useful data from the partial information acquired. As illustrative examples, we describe how CT was instrumental in the analysis of particular aircraft components. These include fuselage panels, single crystal turbine blades, and aluminum-lithium composites.

System-Independent Characterization of Materials Using Dual-Energy Computed Tomography

We present a new decomposition approach for dual-energy computed tomography (DECT) called SIRZ that provides precise and accurate material description, independent of the scanner, over diagnostic energy ranges (30 to 200 keV). System independence is achieved by explicitly including a scanner-specific spectral description in the decomposition method, and a new X-ray-relevant feature space. The feature space consists of electron density, ρe, and a new effective atomic number, Ze, which is based on published X-ray cross sections. Reference materials are used in conjunction with the system spectral response so that additional beam-hardening correction is not necessary. The technique is tested against other methods on DECT data of known specimens scanned by diverse spectra and systems. Uncertainties in accuracy and precision are less than 3% and 2% respectively for the (ρe, Ze) results compared to prior methods that are inaccurate and imprecise (over 9%).

Tomographic image reconstruction and rendering with texture-mapping hardware

The image reconstruction problem, also known as the inverse Radon transform, for x-ray computed tomography (CT) is found in numerous applications in medicine and industry. The most common algorithm used in these cases is filtered backprojection (FBP), which, while a simple procedure, is time-consuming for large images on any type of computational engine. Specially designed, dedicated parallel processors are commonly used in medical CT scanners, whose results are then passed to a graphics workstation for rendering and analysis. However, a fast direct FBP algorithm can be implemented on modern texture-mapping hardware in current high-end workstation platforms. This is done by casting the FBP algorithm as an image warping operation with summing. Texture- mapping hardware, such as that on the silicon Graphics Reality Engine, shows around 600 times speedup of backprojection over a CPU-based implementation (a 100 Mhz R4400 in our case). This technique has the further advantages of flexibility and rapid programming. In addition, the same hardware can be used for both image reconstruction and for volumetric rendering. Our technique can also be used to accelerate iterative reconstruction algorithms. The hardware architecture also allows more complex operations than straight-ray backprojection if they are required, including fan-beam, cone-beam, and curved ray paths, with little or no speed penalties.