Steven Charles Reitz | Researchain

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Featured researches published by Steven Charles Reitz.

Bioorganic & Medicinal Chemistry Letters | 2008

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

Brad A. Acker; E. Jon Jacobsen; Bruce N. Rogers; Donn G. Wishka; Steven Charles Reitz; David W. Piotrowski; Jason K. Myers; Mark L. Wolfe; Vincent E. Groppi; Bruce A. Thornburgh; Paula M. Tinholt; Rodney R. Walters; Barbara A. Olson; Laura Fitzgerald; Brian A. Staton; Thomas J. Raub; Michael Krause; Kai S. Li; William E. Hoffmann; Mihály Hajós; Raymond S. Hurst; Daniel P. Walker

A novel alpha7 nAChR agonist, N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (3a, PHA-709829), has been identified for the potential treatment of cognitive deficits in schizophrenia. The compound shows potent and selective alpha7 in vitro activity, excellent brain penetration, good rat oral bioavailability and robust in vivo efficacy in a rat auditory sensory gating model.

Journal of Medicinal Chemistry | 2006

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia : Synthesis and structure-activity relationship

Donn G. Wishka; Daniel P. Walker; Karen M. Yates; Steven Charles Reitz; Shaojuan Jia; Jason K. Myers; Kirk L. Olson; E. Jon Jacobsen; Mark L. Wolfe; Vincent E. Groppi; Alexander J. Hanchar; Bruce A. Thornburgh; Luz A. Cortes-Burgos; Erik H. F. Wong; Brian A. Staton; Thomas J. Raub; Nicole R. Higdon; Theron M. Wall; Raymond S. Hurst; Rodney R. Walters; William E. Hoffmann; Mihály Hajós; Stanley Franklin; Galen J. Carey; Lisa H. Gold; Karen K. Cook; Steven Bradley Sands; Sabrina X. Zhao; John R. Soglia; Amit S. Kalgutkar

Bioorganic & Medicinal Chemistry | 2006

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

Daniel P. Walker; Donn G. Wishka; David W. Piotrowski; Shaojuan Jia; Steven Charles Reitz; Karen M. Yates; Jason K. Myers; Tatiana N. Vetman; Brandon J. Margolis; E. Jon Jacobsen; Brad A. Acker; Vincent E. Groppi; Mark L. Wolfe; Bruce A. Thornburgh; Paula M. Tinholt; Luz A. Cortes-Burgos; Rodney R. Walters; Matthew R. Hester; Eric P. Seest; Lester A. Dolak; Fusen Han; Barbara A. Olson; Laura Fitzgerald; Brian A. Staton; Thomas J. Raub; Mihály Hajós; William E. Hoffmann; Kai S. Li; Nicole R. Higdon; Theron M. Wall

Archive | 2003